2A9W
E. coli TS complexed with dUMP and inhibitor GA9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Thymidylate synthase | polymer | 264 | 30559.7 | 4 | UniProt (P0A884) Pfam (PF00303) | Escherichia coli | TS, TSase |
| 2 | E, F, FA, GA, HA... (A, D, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 12 | Chemie (PO4) | |||
| 3 | AA, G, IA, R (C, A, D, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
| 4 | BA, H, JA, S (C, A, D, B) | 3,3-BIS(3-BROMO-4-HYDROXYPHENYL)-7-CHLORO-1H,3H-BENZO[DE]ISOCHROMEN-1-ONE | non-polymer | 560.6 | 4 | Chemie (GA9) | |||
| 5 | CA, I, J, KA (C, A, D) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 4 | Chemie (BME) | |||
| 6 | DA, EA, K, L, LA... (C, A, D, B) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 7 | T (B) | 2-BROMOPHENOL | non-polymer | 173.0 | 1 | Chemie (2BR) | |||
| 8 | NA, OA, PA, QA (A, B, C, D) | water | water | 18.0 | 487 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 264 (UniProt: P0A884)
| PDB | External Database | Details |
|---|---|---|
| Cxm 1 | Met 1 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 122238.7 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 6021.3 | |
| All* | Total formula weight | 128260.0 |
