7B4B
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![BU of 7b4b by Molmil](/molmil-images/mine/7b4b) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4G
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![BU of 7b4g by Molmil](/molmil-images/mine/7b4g) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II) | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4F
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![BU of 7b4f by Molmil](/molmil-images/mine/7b4f) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I) | 分子名称: | Cellular tumor antigen p53, DNA target, FORMIC ACID, ... | 著者 | Rozenberg, H, Degtjarik, O, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4H
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![BU of 7b4h by Molmil](/molmil-images/mine/7b4h) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Degtjarik, O, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4E
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![BU of 7b4e by Molmil](/molmil-images/mine/7b4e) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4A
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![BU of 7b4a by Molmil](/molmil-images/mine/7b4a) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA | 分子名称: | Cellular tumor antigen p53, DNA target, FORMIC ACID, ... | 著者 | Golovenko, D, Rozenberg, H, Degtjarik, O, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B47
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![BU of 7b47 by Molmil](/molmil-images/mine/7b47) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B46
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![BU of 7b46 by Molmil](/molmil-images/mine/7b46) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, ACETATE ION, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4C
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![BU of 7b4c by Molmil](/molmil-images/mine/7b4c) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (II) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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2JET
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![BU of 2jet by Molmil](/molmil-images/mine/2jet) | Crystal structure of a trypsin-like mutant (S189D , A226G) chymotrypsin. | 分子名称: | CHYMOTRYPSINOGEN B CHAIN A, CHYMOTRYPSINOGEN B CHAIN B, CHYMOTRYPSINOGEN B CHAIN C | 著者 | Jelinek, B, Katona, G, Fodor, K, Venekei, I, Graf, L. | 登録日 | 2007-01-22 | 公開日 | 2007-09-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Crystal Structure of a Trypsin-Like Mutant Chymotrypsin: The Role of Position 226 in the Activity and Specificity of S189D Chymotrypsin. Protein J., 27, 2008
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2IOI
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![BU of 2ioi by Molmil](/molmil-images/mine/2ioi) | Crystal structure of the mouse p53 core domain at 1.55 A | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular tumor antigen p53, ZINC ION | 著者 | Ho, W.C, Luo, C, Zhao, K, Chai, X, Fitzgerald, M.X, Marmorstein, R. | 登録日 | 2006-10-10 | 公開日 | 2006-12-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. Acta Crystallogr.,Sect.D, 62, 2006
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2IOM
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![BU of 2iom by Molmil](/molmil-images/mine/2iom) | Mouse p53 core domain soaked with 2-propanol | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular tumor antigen p53, ISOPROPYL ALCOHOL, ... | 著者 | Ho, W.C, Luo, C, Zhao, K, Chai, X, Fitzgerald, M.X, Marmorstein, R. | 登録日 | 2006-10-10 | 公開日 | 2006-12-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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2GCH
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![BU of 2gch by Molmil](/molmil-images/mine/2gch) | |
2GCT
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![BU of 2gct by Molmil](/molmil-images/mine/2gct) | |
8E7B
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![BU of 8e7b by Molmil](/molmil-images/mine/8e7b) | Crystal structure of the p53 (Y107H) core domain monoclinic P form | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J. | 登録日 | 2022-08-23 | 公開日 | 2023-05-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. Cancer Discov, 13, 2023
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8E7A
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![BU of 8e7a by Molmil](/molmil-images/mine/8e7a) | Crystal structure of the p53 (Y107H) core domain orthorhombic P form | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J. | 登録日 | 2022-08-23 | 公開日 | 2023-05-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. Cancer Discov, 13, 2023
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2H1L
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![BU of 2h1l by Molmil](/molmil-images/mine/2h1l) | |
8F2I
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![BU of 8f2i by Molmil](/molmil-images/mine/8f2i) | P53 monomer structure | 分子名称: | Cellular tumor antigen p53 | 著者 | Solares, M, Kelly, D.F. | 登録日 | 2022-11-08 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials. Chembiochem, 23, 2022
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8F2H
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![BU of 8f2h by Molmil](/molmil-images/mine/8f2h) | |
5R42
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![BU of 5r42 by Molmil](/molmil-images/mine/5r42) | Crystal Structure of deuterated gamma-Chymotrypsin at pH 7.5, room temperature | 分子名称: | IODIDE ION, gamma-Chymotrypsin, peptide SWPW, ... | 著者 | Kreinbring, C.A, Wilson, M.A, Kovalevsky, A.Y, Blakeley, M.P, Fisher, S.Z, Lazar, L.M, Moulin, A.G, Novak, W.R, Petsko, G.A, Ringe, D. | 登録日 | 2020-02-18 | 公開日 | 2021-09-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Effect of Temperature and pH on Ionizable Residues in gamma-Chymotrypsin: a X-ray and Neutron Crystallography Study To be published
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5R49
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![BU of 5r49 by Molmil](/molmil-images/mine/5r49) | Crystal Structure of gamma-Chymotrypsin at pH 5.6, cryo temperature | 分子名称: | IODIDE ION, MALONATE ION, gamma-chymotrypsin, ... | 著者 | Kreinbring, C.A, Wilson, M.A, Kovalevsky, A.Y, Blakeley, M.P, Fisher, S.Z, Lazar, L.M, Moulin, A.G, Novak, W.R, Petsko, G.A, Ringe, D. | 登録日 | 2020-02-18 | 公開日 | 2021-09-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Effect of Temperature and pH on Ionizable Residues in gamma-Chymotrypsin: a X-ray and Neutron Crystallography Study To be published
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5R45
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![BU of 5r45 by Molmil](/molmil-images/mine/5r45) | Crystal Structure of gamma-Chymotrypsin at pH 7.5, cryo temperature | 分子名称: | Chymotrypsinogen A, IODIDE ION, MALONATE ION, ... | 著者 | Kreinbring, C.A, Wilson, M.A, Kovalevsky, A.Y, Blakeley, M.P, Fisher, S.Z, Lazar, L.M, Moulin, A.G, Novak, W.R, Petsko, G.A, Ringe, D. | 登録日 | 2020-02-18 | 公開日 | 2021-09-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Effect of Temperature and pH on Ionizable Residues in gamma-Chymotrypsin: a X-ray and Neutron Crystallography Study To be published
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5R4C
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![BU of 5r4c by Molmil](/molmil-images/mine/5r4c) | Crystal Structure of gamma-Chymotrypsin at pH 9, room temperature | 分子名称: | IODIDE ION, SULFATE ION, gamma-chymotrypsin, ... | 著者 | Kreinbring, C.A, Wilson, M.A, Kovalevsky, A.Y, Blakeley, M.P, Fisher, S.Z, Lazar, L.M, Moulin, A.G, Novak, W.R, Petsko, G.A, Ringe, D. | 登録日 | 2020-02-18 | 公開日 | 2021-09-01 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Effect of Temperature and pH on Ionizable Residues in gamma-Chymotrypsin: a X-ray and Neutron Crystallography Study To be published
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5R48
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![BU of 5r48 by Molmil](/molmil-images/mine/5r48) | Crystal Structure of gamma-Chymotrypsin at pH 5.6, room temperature | 分子名称: | IODIDE ION, SULFATE ION, gamma-chymotrypsin, ... | 著者 | Kreinbring, C.A, Wilson, M.A, Kovalevsky, A.Y, Blakeley, M.P, Fisher, S.Z, Lazar, L.M, Moulin, A.G, Novak, W.R, Petsko, G.A, Ringe, D. | 登録日 | 2020-02-18 | 公開日 | 2021-09-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Effect of Temperature and pH on Ionizable Residues in gamma-Chymotrypsin: a X-ray and Neutron Crystallography Study To be published
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5R4A
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![BU of 5r4a by Molmil](/molmil-images/mine/5r4a) | Crystal Structure of deuterated gamma-Chymotrypsin at pH 9, room temperature | 分子名称: | IODIDE ION, SULFATE ION, gamma-chymotrypsin, ... | 著者 | Kreinbring, C.A, Wilson, M.A, Kovalevsky, A.Y, Blakeley, M.P, Fisher, S.Z, Lazar, L.M, Moulin, A.G, Novak, W.R, Petsko, G.A, Ringe, D. | 登録日 | 2020-02-18 | 公開日 | 2021-09-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Effect of Temperature and pH on Ionizable Residues in gamma-Chymotrypsin: a X-ray and Neutron Crystallography Study To be published
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