7YID
 
 | | Human KCNH5 closed state 1 | | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | 著者 | Zhang, M.F. | | 登録日 | 2022-07-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
|
|
7YIH
 | | Human KCNH5 open state | | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | 著者 | Zhang, M.F. | | 登録日 | 2022-07-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
|
|
7YIJ
 | | Human KCNH5 pore dilation but the non-conducting state | | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | 著者 | Zhang, M.F. | | 登録日 | 2022-07-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
|
|
7YIF
 | | Human KCNH5 pre-open state 1 | | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | 著者 | Zhang, M.F. | | 登録日 | 2022-07-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
|
|
7YIG
 | | Human KCNH5 pre-open state 2 | | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | 著者 | Zhang, M.F. | | 登録日 | 2022-07-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
|
|
7YIE
 | | Human KCNH5-closed state 2 | | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | 著者 | Zhang, M.F. | | 登録日 | 2022-07-16 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
|
|
8PD8
 | | cAMP-bound SpSLC9C1 in lipid nanodiscs, dimer | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-12 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PD3
 | | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 2 | | 分子名称: | Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PCZ
 | | Ligand-free SpSLC9C1 in lipid nanodiscs, dimer | | 分子名称: | Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PD7
 | | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 4 | | 分子名称: | Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PD5
 | | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 3 | | 分子名称: | Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PD2
 | | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 1 | | 分子名称: | Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PD9
 | | cAMP-bound SpSLC9C1 in lipid nanodiscs, protomer state 1 | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-12 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PDV
 | | cGMP-bound SpSLC9C1 in lipid nanodiscs, protomer | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-12 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
8PDU
 | | cGMP-bound SpSLC9C1 in lipid nanodiscs, dimer | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Sperm-specific sodium proton exchanger | | 著者 | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | | 登録日 | 2023-06-12 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Nature, 623, 2023
|
|
3TNP
 | | Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | | 分子名称: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | | 登録日 | 2011-09-01 | | 公開日 | 2012-02-01 | | 最終更新日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme
Science, 335, 2012
|
|
8T4M
 | | Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | | 登録日 | 2023-06-09 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Nat Commun, 15, 2024
|
|
5DYL
 | | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - Apo form | | 分子名称: | cGMP-dependent protein kinase, putative | | 著者 | Wernimont, A.K, Tempel, W, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) | | 登録日 | 2015-09-24 | | 公開日 | 2015-11-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
5E44
 | |
5DYK
 | | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum - Apo form | | 分子名称: | 1,2-ETHANEDIOL, CGMP-dependent protein kinase, GLYCEROL, ... | | 著者 | Wernimont, A.K, Tempel, W, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) | | 登録日 | 2015-09-24 | | 公開日 | 2015-11-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
5DZC
 | | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - AMPPNP bound | | 分子名称: | CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... | | 著者 | Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, He, H, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | | 登録日 | 2015-09-25 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
8EP1
 | |
8EM8
 | | Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165 | | 分子名称: | UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ... | | 著者 | Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2022-09-27 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
J.Med.Chem., 67, 2024
|
|
8EOW
 | |
8EP0
 | |
