8E9F
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7RC1
| X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686 | 分子名称: | 3C-like proteinase, 5-chloropyridin-3-yl 1-(3-nitrobenzene-1-sulfonyl)-1H-indole-5-carboxylate, DIMETHYL SULFOXIDE | 著者 | Mesecar, A.D, Anson, B.A, Ghosh, A.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-07 | 公開日 | 2021-09-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. J.Med.Chem., 64, 2021
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6USS
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8JPC
| cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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6UT7
| Fitted model for the tetradecameric assembly of Thermococcus gammatolerans McrB AAA+ hexamers with bound McrC | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase subunit of restriction endonuclease, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Niu, Y, Suzuki, H, Hosford, C.J, Chappie, J.S, Walz, T. | 登録日 | 2019-10-29 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.26 Å) | 主引用文献 | Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes. Nat Commun, 11, 2020
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8EDC
| Structure of C. elegans UNC-5 IG 1+2 Domains | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Netrin receptor unc-5, SULFATE ION | 著者 | Priest, J.M, Ozkan, E. | 登録日 | 2022-09-04 | 公開日 | 2023-01-11 | 最終更新日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structural insights into the formation of repulsive netrin guidance complexes. Sci Adv, 10, 2024
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7LC5
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8JPB
| cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8DQP
| Crystal structure of Arabidopsis thaliana COSY in complex with scopoletin | 分子名称: | 1,2-ETHANEDIOL, 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one, ACETATE ION, ... | 著者 | Kim, C.Y, Mitchell, A.J, Gutierrez, M, Weng, J.K. | 登録日 | 2022-07-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY. Nat Commun, 14, 2023
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8E1W
| Neutron crystal structure of Panus similis AA9A at room temperature | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COPPER (II) ION, ... | 著者 | Meilleur, F, Tandrup, T, Lo Leggio, L. | 登録日 | 2022-08-11 | 公開日 | 2023-01-11 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (2.1 Å), X-RAY DIFFRACTION | 主引用文献 | Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature. Acta Crystallogr.,Sect.F, 79, 2023
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6UUL
| Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, D5 Fab Heavy Chain, ... | 著者 | Kumar, S, Wilson, I.A. | 登録日 | 2019-10-30 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv, 6, 2020
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7M0S
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8JPF
| Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, NTS, Neurotensin receptor type 1 | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8DV6
| Zika virus envelope protein structure in complex with a potent Human mAb | 分子名称: | Envelope protein E, mAb Fab Heavy Chain, mAb Fab Light Chain | 著者 | Cameron, A, Puhl, A.C, deSilva, A.M, Premkumar, L. | 登録日 | 2022-07-28 | 公開日 | 2023-01-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | 主引用文献 | Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus. Plos Pathog., 19, 2023
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7RBZ
| X-ray Structure of SARS-CoV-2 main protease covalently modified by compound GRL-017-20 | 分子名称: | 3C-like proteinase, 5-chloropyridin-3-yl 2,3-dihydro-1H-indole-4-carboxylate | 著者 | Mesecar, A.D, Anson, B.A, Ghosh, A.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-06 | 公開日 | 2021-09-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. J.Med.Chem., 64, 2021
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7TY7
| Cryo-EM structure of human Anion Exchanger 1 bound to Bicarbonate | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, ... | 著者 | Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | 登録日 | 2022-02-11 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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8DQQ
| Crystal structure of Arabidopsis thaliana COSY in complex with scopoletin | 分子名称: | 7-hydroxy-2H-chromen-2-one, ACETATE ION, CALCIUM ION, ... | 著者 | Kim, C.Y, Mitchell, A.J, Gutierrez, M, Weng, J.K. | 登録日 | 2022-07-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY. Nat Commun, 14, 2023
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7TY6
| Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatodihydrostilbene-2,2'-Disulfonic Acid (H2DIDS) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ... | 著者 | Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | 登録日 | 2022-02-11 | 公開日 | 2023-08-16 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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7LAD
| Clobetasol propionate bound to CYP3A5 | 分子名称: | Clobetasol propionate, Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Buchman, C.D, Miller, D, Wang, J, Jayaraman, S, Chen, T. | 登録日 | 2021-01-06 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. J.Am.Chem.Soc., 143, 2021
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8OEI
| SFX structure of FutA after an accumulated dose of 350 kGy | 分子名称: | FE (III) ION, Putative iron ABC transporter, substrate binding protein | 著者 | Bolton, R, Tews, I. | 登録日 | 2023-03-10 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proc.Natl.Acad.Sci.USA, 121, 2024
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7LTN
| Crystal structure of Mpro in complex with inhibitor CDD-1713 | 分子名称: | 2-[4-(1~{H}-indazol-4-yl)-2-methanoyl-6-methoxy-phenoxy]-~{N},~{N}-dimethyl-ethanamide, 3C-like proteinase | 著者 | Lu, S, Palzkill, T, Matzuk, M, Young, D, Melek, N, Chamakuri, S. | 登録日 | 2021-02-19 | 公開日 | 2021-11-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors. Proc.Natl.Acad.Sci.USA, 118, 2021
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6UZU
| Carbonic Anhydrase IX-mimic In Complex WITH U-CH3 | 分子名称: | 4-{[(3,5-dimethylphenyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | McKenna, R, Mboge, M.Y, Mahon, B.P. | 登録日 | 2019-11-15 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides. Eur J Med Chem, 132, 2017
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7TY4
| Cryo-EM structure of human Anion Exchanger 1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, ... | 著者 | Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | 登録日 | 2022-02-11 | 公開日 | 2023-08-16 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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8DSR
| Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 in complex with UCB7362 | 分子名称: | (2E,6S)-6-{2-chloro-3-[(2-cyclopropylpyrimidin-5-yl)amino]phenyl}-2-imino-6-methyl-3-[(2S,4S)-2-methyloxan-4-yl]-1,3-diazinan-4-one, Plasmepsin X | 著者 | Abendroth, J, Lorimer, D.D. | 登録日 | 2022-07-22 | 公開日 | 2022-10-19 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 . J.Med.Chem., 65, 2022
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7TYA
| Cryo-EM structure of human Anion Exchanger 1 modified with Diethyl Pyrocarbonate (DEPC) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, ... | 著者 | Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | 登録日 | 2022-02-11 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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