PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

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5NN3	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M. 登録日 2017-04-08 公開日 2017-10-25 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8, 2017
5UF7	CRYSTAL STRUCTURE OF MUNC13-1 MUN DOMAIN 分子名称: Protein unc-13 homolog A 著者 Tomchick, D.R, Rizo, J, Xu, J. 登録日 2017-01-03 公開日 2017-02-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.896 Å) 主引用文献 Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN. Elife, 6, 2017
6TC3	Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 1) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Innis, C.A, Herrero del Valle, A. 登録日 2019-11-05 公開日 2020-01-01 最終更新日 2025-03-12 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Ornithine capture by a translating ribosome controls bacterial polyamine synthesis. Nat Microbiol, 5, 2020
5ECL	Crystal Structure of FIN219-FIP1 complex with JA, Ile and Mg 分子名称: GLUTATHIONE, Glutathione S-transferase U20, ISOLEUCINE, ... 著者 Chen, C.Y, Cheng, Y.S. 登録日 2015-10-20 公開日 2016-11-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural basis of jasmonate-amido synthetase FIN219 in complex with glutathione S-transferase FIP1 during the JA signal regulation Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1U27	Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4 分子名称: Cytohesin 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE 著者 Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. 登録日 2004-07-16 公開日 2005-02-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
6AX4	Plk-1 polo-box domain in complex with histidine N(tau)-cyclized Macrocycle 5b. 分子名称: AMYLAMINE, Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b 著者 Grant, R.A, Hymel, D, Yaffe, M.B, Burke, T.R. 登録日 2017-09-06 公開日 2018-09-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
2RSV	Solution structure of human full-length vaccinia related kinase 1 (VRK1) 分子名称: Serine/threonine-protein kinase VRK1 著者 Koshiba, S, Tochio, N, Yokoyama, J, Kigawa, T. 登録日 2012-07-12 公開日 2013-12-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A strategy for structure determination of large molecular weight protein using isotope labeling methodology with cell-free protein systhesis: application to 45 kDa human vaccinia related kianse 1 (VRK1) To be Published
7HF1	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with AVI-0003761 分子名称: 1-{[(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]methyl}cyclohexan-1-ol, CHLORIDE ION, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2024-08-15 公開日 2025-06-11 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning. Sci Adv, 11, 2025
4OY2	Crystal structure of TAF1-TAF7, a TFIID subcomplex 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7, ... 著者 Bhattacharya, S, Lou, X, Rajashankar, K, Jacobson, R.H, Webb, P. 登録日 2014-02-10 公開日 2014-06-25 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc.Natl.Acad.Sci.USA, 111, 2014
5ECH	Crystal Structure of FIN219-FIP1 complex with JA and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE, Glutathione S-transferase U20, ... 著者 Chen, C.Y, Cheng, Y.S. 登録日 2015-10-20 公開日 2016-11-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structural basis of jasmonate-amido synthetase FIN219 in complex with glutathione S-transferase FIP1 during the JA signal regulation Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3LDJ	Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding 分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, Pancreatic trypsin inhibitor 著者 Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. 登録日 2010-01-13 公開日 2010-09-15 最終更新日 2025-05-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding. Biochem.Biophys.Res.Commun., 2010
1O86	Crystal Structure of Human Angiotensin Converting Enzyme in complex with lisinopril. 分子名称: ANGIOTENSIN CONVERTING ENZYME, CHLORIDE ION, GLYCINE, ... 著者 Natesh, R, Schwager, S.L.U, Sturrock, E.D, Acharya, K.R. 登録日 2002-11-25 公開日 2003-02-07 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Human Angiotensin-Converting Enzyme-Lisinopril Complex Nature, 421, 2003
7HFY	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with AVI-0006217 分子名称: 1-{[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]methyl}cyclohexan-1-ol, CHLORIDE ION, Non-structural protein 3 著者 Correy, G.J, Fraser, J.S. 登録日 2024-08-15 公開日 2025-06-11 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning. Sci Adv, 11, 2025
7HF6	PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with AVI-0003760 分子名称: 1-{[(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]methyl}cyclopentan-1-ol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Correy, G.J, Fraser, J.S. 登録日 2024-08-15 公開日 2025-06-11 実験手法 X-RAY DIFFRACTION (0.99 Å) 主引用文献 Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning. Sci Adv, 11, 2025
3F67	Crystal Structure of Putative Dienelactone Hydrolase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, FORMIC ACID, ... 著者 Kim, Y, Li, H, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2008-11-05 公開日 2008-11-25 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal Structure of Putative Dienelactone Hydrolase from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 To be Published
6HVU	Yeast 20S proteasome with human beta2i (1-53) in complex with 29 分子名称: CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... 著者 Huber, E.M, Groll, M. 登録日 2018-10-11 公開日 2019-01-30 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. J.Med.Chem., 62, 2019
1KNT	THE 1.6 ANGSTROMS STRUCTURE OF THE KUNITZ-TYPE DOMAIN FROM THE ALPHA3 CHAIN OF THE HUMAN TYPE VI COLLAGEN 分子名称: COLLAGEN TYPE VI, SULFATE ION 著者 Arnoux, B, Merigeau, K, Saludjian, P, Norris, F, Norris, K, Bjorn, S, Olsen, O, Petersen, L, Ducruix, A. 登録日 1994-08-18 公開日 1994-11-01 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen. J.Mol.Biol., 246, 1995
5FL4	Three dimensional structure of human carbonic anhydrase IX in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide 分子名称: 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide, ACETIC ACID, CARBONIC ANHYDRASE 9, ... 著者 Leitans, J, Tars, K, Zalubovskis, R. 登録日 2015-10-21 公開日 2015-11-11 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 An Efficient Expression and Crystallization System of the Cancer Asociated Carbonic Anhydrase Isoform Ix. J.Med.Chem., 58, 2015
4O78	Crystal structure of the first bromodomain of human BRD4 in complex with GW612286X 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, CHLORIDE ION, ... 著者 Zhu, J.-Y, Ember, S.W, Watts, C, Schonbrunn, E. 登録日 2013-12-24 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
3FJD	Crystal structure of L44F/F132W mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. J.Mol.Biol., 393, 2009
9K9N	Cryo-EM structure of MjHKU4r-CoV-1 receptor-binding domain complexed with human CD26 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sun, J.Q. 登録日 2024-10-27 公開日 2025-09-03 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Rational design of human CD26 receptor for a strong neutralizing ability against MjHKU4r-CoV-1 and MERS-CoV Hlife, 2025
5UIQ	Crystal structure of IRAK4 in complex with compound 9 分子名称: 2-[(propan-2-yl)oxy]benzamide, Interleukin-1 receptor-associated kinase 4 著者 Han, S, Chang, J.S. 登録日 2017-01-14 公開日 2017-05-24 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
5UIS	Crystal structure of IRAK4 in complex with compound 12 分子名称: 4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide, Interleukin-1 receptor-associated kinase 4 著者 Han, S, Chang, J.S. 登録日 2017-01-14 公開日 2017-05-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
1KZV	Structure of Human Immunodeficiency Virus Type 1 Vpr(34-51) Peptide in Chloroform Methanol 分子名称: Vpr PROTEIN 著者 Engler, A, Stangler, T, Willbold, D. 登録日 2002-02-08 公開日 2002-08-28 最終更新日 2024-11-13 実験手法 SOLUTION NMR 主引用文献 Structure of human immunodeficiency virus type 1 Vpr(34-51) peptide in micelle containing aqueous solution. Eur.J.Biochem., 269, 2002
7HQS	PanDDA analysis group deposition -- Crystal Structure of FatA in complex with Z56912586 分子名称: 1,3-benzothiazol-2-amine, Oleoyl-acyl carrier protein thioesterase 1, chloroplastic, ... 著者 Kot, E, Ni, X, Tomlinson, C.W.E, Fearon, D, Aschenbrenner, J.C, Fairhead, M, Koekemoer, L, Marx, M.L, Wright, N.D, Mulholland, N.P, Montgomery, M.G, von Delft, F. 登録日 2024-12-23 公開日 2025-08-13 実験手法 X-RAY DIFFRACTION (1.617 Å) 主引用文献 PanDDA analysis group deposition To Be Published

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