6GC6
| 50S ribosomal subunit assembly intermediate state 2 | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Nikolay, R, Hilal, T, Qin, B, Loerke, J, Buerger, J, Mielke, T, Spahn, C.M.T. | 登録日 | 2018-04-17 | 公開日 | 2018-07-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution. Mol. Cell, 70, 2018
|
|
3H7I
| |
5HYK
| Crystal structure of the complex PPARalpha/AL26-29 | 分子名称: | 2-methyl-2-[4-(naphthalen-1-yl)phenoxy]propanoic acid, Peroxisome proliferator-activated receptor alpha | 著者 | Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Lavecchia, A. | 登録日 | 2016-02-01 | 公開日 | 2016-11-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode. Sci Rep, 6, 2016
|
|
1YXU
| Crystal Structure of Kinase Pim1 in Complex with AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | 登録日 | 2005-02-22 | 公開日 | 2005-04-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma. J.Mol.Biol., 348, 2005
|
|
1J2B
| Crystal Structure Of Archaeosine tRNA-Guanine Transglycosylase Complexed With lambda-form tRNA(Val) | 分子名称: | Archaeosine tRNA-guanine transglycosylase, MAGNESIUM ION, ZINC ION, ... | 著者 | Ishitani, R, Nureki, O, Nameki, N, Okada, N, Nishimura, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-12-29 | 公開日 | 2003-05-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme Cell(Cambridge,Mass.), 113, 2003
|
|
1YXX
| Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | 分子名称: | (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | 登録日 | 2005-02-22 | 公開日 | 2005-04-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J.Mol.Biol., 348, 2005
|
|
1J5E
| Structure of the Thermus thermophilus 30S Ribosomal Subunit | 分子名称: | 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... | 著者 | Wimberly, B.T, Brodersen, D.E, Clemons Jr, W.M, Morgan-Warren, R, Carter, A.P, Vonrhein, C, Hartsch, T, Ramakrishnan, V. | 登録日 | 2002-04-08 | 公開日 | 2002-04-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structure of the 30S ribosomal subunit. Nature, 407, 2000
|
|
1IZD
| Crystal structure of Aspergillus oryzae Aspartic Proteinase | 分子名称: | Aspartic proteinase, alpha-D-mannopyranose | 著者 | Kamitori, S, Ohtaki, A, Ino, H, Takeuchi, M. | 登録日 | 2002-10-02 | 公開日 | 2003-03-04 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structures of Aspergillus oryzae Aspartic Proteinase and its Complex with an Inhibitor Pepstatin at 1.9 A Resolution J.Mol.Biol., 326, 2003
|
|
1J1U
| Crystal structure of archaeal tyrosyl-tRNA synthetase complexed with tRNA(Tyr) and L-tyrosine | 分子名称: | MAGNESIUM ION, TYROSINE, Tyrosyl-tRNA synthetase, ... | 著者 | Kobayashi, T, Nureki, O, Ishitani, R, Tukalo, M, Cusack, S, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-12-17 | 公開日 | 2003-06-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion NAT.STRUCT.BIOL., 10, 2003
|
|
5FN3
| Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-11 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
|
|
8OQY
| Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | 登録日 | 2023-04-12 | 公開日 | 2024-04-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform. Nat Commun, 15, 2024
|
|
8OQZ
| Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | 登録日 | 2023-04-12 | 公開日 | 2024-04-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform. Nat Commun, 15, 2024
|
|
2BZH
| CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, ... | 著者 | Debreczeni, J.E, Bullock, A, Knapp, S, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A. | 登録日 | 2005-08-18 | 公開日 | 2005-12-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands To be Published
|
|
1G1X
| STRUCTURE OF RIBOSOMAL PROTEINS S15, S6, S18, AND 16S RIBOSOMAL RNA | 分子名称: | 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S15, 30S RIBOSOMAL PROTEIN S18, ... | 著者 | Agalarov, S.C, Prasad, G.S, Funke, P.M, Stout, C.D, Williamson, J.R. | 登録日 | 2000-10-13 | 公開日 | 2000-10-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain. Science, 288, 2000
|
|
2H13
| |
6WJ3
| |
1G2M
| FACTOR XA INHIBITOR COMPLEX | 分子名称: | 4-{[1-METHYL-5-(2-METHYL-BENZOIMIDAZOL-1-YLMETHYL)-1H-BENZOIMIDAZOL-2-YLMETHYL]-AMINO}-BENZAMIDINE, CALCIUM ION, COAGULATION FACTOR X | 著者 | Nar, H. | 登録日 | 2000-10-20 | 公開日 | 2001-10-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors. Structure, 9, 2001
|
|
5FN2
| Cryo-EM structure of gamma secretase in complex with a drug DAPT | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
|
|
2B9B
| Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0 | 著者 | Yin, H.-S, Wen, X, Paterson, R.G, Lamb, R.A, Jardetzky, T.S. | 登録日 | 2005-10-11 | 公開日 | 2006-01-24 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation Nature, 439, 2006
|
|
3IMQ
| Crystal structure of the NusB101-S10(delta loop) complex | 分子名称: | 30S ribosomal protein S10, N utilization substance protein B, POTASSIUM ION | 著者 | Luo, X, Wahl, M.C. | 登録日 | 2009-08-11 | 公開日 | 2009-11-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination. Nucleic Acids Res., 38, 2010
|
|
5H6R
| Crystal structure of LSD1-CoREST in complex with peptide 13 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | 著者 | Kkuchi, M, Amano, Y, Sato, S, Yokoyama, S, Umezawa, N, Higuchi, T, Umehara, T. | 登録日 | 2016-11-14 | 公開日 | 2017-04-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg. Med. Chem., 25, 2017
|
|
5Q01
| Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea | 分子名称: | Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-[(3,4-dichloro-1-methyl-1H-pyrazol-5-yl)oxy]benzene-1-sulfonamide | 著者 | Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-04-18 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the
allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea To be published
|
|
5Q03
| Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methylpropyl)thiophen-2-yl]sulfonylurea | 分子名称: | Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methylpropyl)thiophene-2-sulfonamide | 著者 | Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-04-18 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the
allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methylpropyl)thiophen-2-yl]sulfonylurea To be published
|
|
5LGM
| |
1IG1
| 1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn. | 分子名称: | MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, death-associated protein kinase | 著者 | Tereshko, V, Teplova, M, Brunzelle, J, Watterson, D.M, Egli, M. | 登録日 | 2001-04-16 | 公開日 | 2002-04-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat.Struct.Biol., 8, 2001
|
|