PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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3DAJ	Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering 分子名称: N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide, serine/threonine kinase 6 著者 He, M.M. 登録日 2008-05-29 公開日 2008-07-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry. Bioorg.Med.Chem.Lett., 18, 2008
3GG5	Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability 分子名称: PHOSPHATE ION, SULFATE ION, Thymidylate synthase 著者 Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Lebioda, L. 登録日 2009-02-27 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
3GH2	Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability 分子名称: SULFATE ION, Thymidylate synthase 著者 Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Lebioda, L. 登録日 2009-03-02 公開日 2010-03-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010
3GJ5	Crystal structure of human RanGDP-Nup153ZnF4 complex 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Partridge, J.R, Schwartz, T.U. 登録日 2009-03-07 公開日 2009-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Crystallographic and Biochemical Analysis of the Ran-binding Zinc Finger Domain. J.Mol.Biol., 391, 2009
3GFC	Crystal Structure of Histone-binding protein RBBP4 分子名称: Histone-binding protein RBBP4 著者 Amaya, M.F, Dong, A, Li, Z, He, H, Ni, S, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) 登録日 2009-02-26 公開日 2009-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
3DXM	Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548 分子名称: (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... 著者 Nolen, B.J, Tomasevic, N, Russell, A, Pierce, D.W, Jia, Z, Hartman, J, Sakowicz, R, Pollard, T.D. 登録日 2008-07-24 公開日 2009-07-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Characterization of two classes of small molecule inhibitors of Arp2/3 complex Nature, 460, 2009
4CY1	Crystal structure of the KANSL1-WDR5 complex. 分子名称: GLYCEROL, KAT8 REGULATORY NSL COMPLEX SUBUNIT 1, WD REPEAT-CONTAINING PROTEIN 5 著者 Dias, J, Brettschneider, J, Cusack, S, Kadlec, J. 登録日 2014-04-09 公開日 2014-05-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex. Genes Dev., 28, 2014
3DFO	Dihydroxyacetone phosphate Schiff base and enamine intermediates in D33N mutant fructose-1,6-bisphosphate aldolase from rabbit muscle 分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase A 著者 St-Jean, M, Sygusch, J. 登録日 2008-06-12 公開日 2009-04-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase Biochemistry, 48, 2009
4CI3	Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide 分子名称: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... 著者 Fischer, E.S, Boehm, K, Thoma, N.H. 登録日 2013-12-05 公開日 2014-07-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
3DFQ	D33S mutant fructose-1,6-bisphosphate aldolase from rabbit muscle 分子名称: Fructose-bisphosphate aldolase A 著者 St-Jean, M, Sygusch, J. 登録日 2008-06-12 公開日 2009-04-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase Biochemistry, 48, 2009
4CN0	An intertwined homodimer of the PDZ homology domain of AHNAK2 分子名称: POTASSIUM ION, PROTEIN AHNAK2, TETRAETHYLENE GLYCOL 著者 Han, H, Kursula, P. 登録日 2014-01-20 公開日 2014-04-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Periaxin and Ahnak Nucleoprotein 2 Form Intertwined Homodimers Through Domain Swapping J.Biol.Chem., 289, 2014
3GN7	PARP complexed with A861696 分子名称: 2-[(2S)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide, Poly [ADP-ribose] polymerase 1 著者 Park, C.H. 登録日 2009-03-16 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 PARP complexed with A861696 To be Published
4BYJ	Aurora A kinase bound to a highly selective imidazopyridine inhibitor 分子名称: (S)-N-(1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)acetamide, AURORA KINASE A 著者 Joshi, A, Kosmopoulou, M, Bayliss, R. 登録日 2013-07-19 公開日 2013-11-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells. J.Med.Chem., 56, 2013
4CDG	Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody 分子名称: ADENOSINE-5'-DIPHOSPHATE, BLOOM SYNDROME PROTEIN, NANOBODY, ... 著者 Newman, J.A, Savitsky, P, Allerston, C.K, Pike, A.C.W, Pardon, E, Steyaert, J, Arrowsmith, C.H, von Delft, F, Bountra, C, Edwards, A, Gileadi, O. 登録日 2013-10-31 公開日 2013-11-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.794 Å) 主引用文献 Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes. Nucleic Acids Res., 43, 2015
4C5I	Crystal structure of MBTD1 YY1 complex 分子名称: MBT DOMAIN-CONTAINING PROTEIN 1, TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 著者 Alfieri, C, Glatt, S, Mueller, C.W. 登録日 2013-09-12 公開日 2013-11-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.586 Å) 主引用文献 Structural Basis for Targeting the Chromatin Repressor Sfmbt to Polycomb Response Elements Genes Dev., 27, 2013
4CCG	Structure of an E2-E3 complex 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CHLORIDE ION, ... 著者 Hodson, C, Purkiss, A, Walden, H. 登録日 2013-10-22 公開日 2014-01-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the Human Fancl Ring-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection. Structure, 22, 2014
4BYI	Aurora A kinase bound to a highly selective imidazopyridine inhibitor 分子名称: (S)-N-((1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)methyl)acetamide, AURORA KINASE A 著者 Joshi, A, Kosmopoulou, M, Bayliss, R. 登録日 2013-07-19 公開日 2013-11-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells. J.Med.Chem., 56, 2013
4CCM	60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with Mn(II), N-oxalylglycine (NOG) and 60S ribosomal protein L8 (RPL8 G220C) peptide fragment (complex-1) 分子名称: 1,2-ETHANEDIOL, 60S RIBOSOMAL PROTEIN L8, BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, ... 著者 Chowdhury, R, Schofield, C.J. 登録日 2013-10-23 公開日 2014-05-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014
3D2W	Crystal structure of mouse TDP-43 RRM2 domain in complex with DNA 分子名称: DNA (5'-D(*DGP*DTP*DTP*DGP*DAP*DGP*DCP*DGP*DTP*DT)-3'), PHOSPHATE ION, TAR DNA-binding protein 43 著者 Kuo, P.H, Yuan, H.S. 登録日 2008-05-09 公開日 2009-04-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into TDP-43 in nucleic-acid binding and domain interactions Nucleic Acids Res., 37, 2009
4ERQ	X-ray structure of WDR5-MLL2 Win motif peptide binary complex 分子名称: Histone-lysine N-methyltransferase MLL2, WD repeat-containing protein 5 著者 Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. 登録日 2012-04-20 公開日 2012-05-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
4F7U	The 6S snRNP assembly intermediate 分子名称: HEXAETHYLENE GLYCOL, Methylosome subunit pICln, Small nuclear ribonucleoprotein E, ... 著者 Grimm, C, Pelz, J.P. 登録日 2012-05-16 公開日 2013-01-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Structural Basis of Assembly Chaperone- Mediated snRNP Formation. Mol.Cell, 49, 2013
3HB8	Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, PHOSPHATE ION, ... 著者 Gibson, L.M, Lovelace, L.L, Lebioda, L. 登録日 2009-05-04 公開日 2010-05-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. Acta Crystallogr.,Sect.D, 67, 2011
4F3I	Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate 著者 Joshua, J, Zhou, M.-M, Plotnikov, A.N. 登録日 2012-05-09 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition. J.Biol.Chem., 287, 2012
3GJX	Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP 分子名称: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Monecke, T, Guettler, T, Neumann, P, Dickmanns, A, Goerlich, D, Ficner, R. 登録日 2009-03-09 公開日 2009-05-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP. Science, 2009
4F38	Crystal structure of geranylgeranylated RhoA in complex with RhoGDI in its active GPPNHP-bound form 分子名称: GERAN-8-YL GERAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Guo, Z, Tnimov, Z, Alexandrov, K. 登録日 2012-05-09 公開日 2012-05-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI. J.Biol.Chem., 287, 2012

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