PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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4BDC	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, N-(furan-2-ylmethyl)quinoxaline-6-carboxamide, ... 著者 Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. 登録日 2012-10-05 公開日 2013-06-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013
3D0Q	Crystal structure of calG3 from Micromonospora echinospora determined in space group I222 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Protein CalG3 著者 Bitto, E, Singh, S, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N. 登録日 2008-05-02 公開日 2008-06-24 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chem.Biol., 15, 2008
5KM6	Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside phosphoramidate substrate complex 分子名称: Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic acid 著者 Maize, K.M, Finzel, B.C. 登録日 2016-06-26 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
4AXE	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, INOSITOL-PENTAKISPHOSPHATE 2-KINASE, SULFATE ION, ... 著者 I Banos-Sanz, J, Sanz-Aparicio, J, Gonzalez, B. 登録日 2012-06-12 公開日 2012-07-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Lobe and Enantiomeric Substrate Preference J.Biol.Chem., 287, 2012
5KM2	Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) CMP catalytic product complex 分子名称: CHLORIDE ION, CYTIDINE-5'-MONOPHOSPHATE, GLYCEROL, ... 著者 Maize, K.M, Finzel, B.C. 登録日 2016-06-26 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
4AXD	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with AMPPNP 分子名称: CITRIC ACID, INOSITOL-PENTAKISPHOSPHATE 2-KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 I Banos-Sanz, J, Sanz-Aparicio, J, Gonzalez, B. 登録日 2012-06-12 公開日 2012-07-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Lobe and Enantiomeric Substrate Preference J.Biol.Chem., 287, 2012
4AXC	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase apo form 分子名称: GLYCEROL, INOSITOL-PENTAKISPHOSPHATE 2-KINASE, SULFATE ION, ... 著者 I Banos-Sanz, J, Sanz-Aparicio, J, Gonzalez, B. 登録日 2012-06-12 公開日 2012-07-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Lobe and Enantiomeric Substrate Preference J.Biol.Chem., 287, 2012
6A51	Novel Regulators CheP and CheQ Specifically Control Chemotaxis Core Gene cheVAW Transcription in Bacterial Pathogen Campylobacter jejuni 分子名称: CheQ 著者 Lu, G, Gao, B, Cha, G, Chen, Z, Mo, R. 登録日 2018-06-21 公開日 2019-06-26 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The novel regulators CheP and CheQ control the core chemotaxis operon cheVAW in Campylobacter jejuni. Mol.Microbiol., 111, 2019
2CZJ	Crystal structure of the tRNA domain of tmRNA from Thermus thermophilus HB8 分子名称: SsrA-binding protein, tmRNA (63-MER) 著者 Bessho, Y, Shibata, R, Sekine, S, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-07-13 公開日 2006-10-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA. Proc.Natl.Acad.Sci.Usa, 104, 2007
6DMA	DHD15_closed 分子名称: DHD15_closed_A, DHD15_closed_B 著者 Bick, M.J, Chen, Z, Baker, D. 登録日 2018-06-04 公開日 2018-12-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.363 Å) 主引用文献 Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
4BDD	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 分子名称: 1,2-ETHANEDIOL, 1-(TERT-BUTYL)-3-(QUINOXALIN-6-YL)UREA, NITRATE ION, ... 著者 Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. 登録日 2012-10-05 公開日 2013-06-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013
3COP	Crystal Structure of E.coli GS mutant E377A in complex with ADP and acceptor analogue HEPPSO 分子名称: (2R)-2-hydroxy-3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid, ADENOSINE-5'-DIPHOSPHATE, Glycogen synthase, ... 著者 Sheng, F, Geiger, J.H. 登録日 2008-03-28 公開日 2009-03-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Crystal Structures of the Open and Catalytically Competent Closed Conformation of Escherichia coli Glycogen Synthase. J.Biol.Chem., 284, 2009
2CV2	Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu) and an enzyme inhibitor, Glu-AMS 分子名称: CHLORIDE ION, MAGNESIUM ION, O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE, ... 著者 Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-31 公開日 2006-09-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase Structure, 14, 2006
4BLA	Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form II) 分子名称: MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG 著者 Cherry, A.L, Finta, C, Karlstrom, M, Toftgard, R, Jovine, L. 登録日 2013-05-02 公開日 2013-11-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation Acta Crystallogr.,Sect.D, 69, 2013
8SZV	Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog SJPYT-318 分子名称: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-[(4-phenoxyphenyl)methyl]benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 著者 Huber, A.D, Poudel, S, Miller, D.J, Li, Y, Chen, T. 登録日 2023-05-30 公開日 2023-10-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand. Structure, 31, 2023
4BDE	Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 分子名称: 1,2-ETHANEDIOL, 6-METHYLQUINAZOLIN-4-AMINE, NITRATE ION, ... 著者 Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. 登録日 2012-10-05 公開日 2013-06-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013
3CQN	Crystal Structure of the Lipocalin domain of Violaxanthin de-epoxidase (VDE) at pH7 分子名称: Violaxanthin de-epoxidase, chloroplast 著者 Arnoux, P, Morosinotto, T, Pignol, D. 登録日 2008-04-03 公開日 2009-04-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A structural basis for the pH-dependent xanthophyll cycle in Arabidopsis thaliana. Plant Cell, 21, 2009
3CS0	Crystal structure of DegP24 分子名称: Periplasmic serine endoprotease DegP, pentapeptide 著者 Krojer, T, Sawa, J, Schaefer, E, Saibil, H.R, Ehrmann, M, Clausen, T. 登録日 2008-04-08 公開日 2008-05-27 最終更新日 2019-11-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for the regulated protease and chaperone function of DegP Nature, 453, 2008
3CSB	Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... 著者 Gilbreth, R.N, Koide, S. 登録日 2008-04-09 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces J.Mol.Biol., 381, 2008
3CX5	Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. 分子名称: (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (1R)-2-(phosphonooxy)-1-[(tridecanoyloxy)methyl]ethyl pentadecanoate, (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, ... 著者 Solmaz, S.R.N, Hunte, C. 登録日 2008-04-23 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. J.Biol.Chem., 283, 2008
2D5R	Crystal Structure of a Tob-hCaf1 Complex 分子名称: CCR4-NOT transcription complex subunit 7, Tob1 protein 著者 Horiuchi, M, Suzuki, N.N, Muroya, N, Takahasi, K, Nishida, M, Yoshida, Y, Ikematsu, N, Nakamura, T, Kawamura-Tsuzuku, J, Yamamoto, T, Inagaki, F. 登録日 2005-11-04 公開日 2006-12-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. J.Biol.Chem., 284, 2009
3D1B	Tetragonal crystal structure of Tas3 C-terminal alpha motif 分子名称: RNA-induced transcriptional silencing complex protein tas3 著者 Li, H, Patel, D.J. 登録日 2008-05-05 公開日 2009-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol.Cell, 34, 2009
3D36	How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the Inhibitor Sda 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Bick, M.J, Lamour, V, Rajashankar, K.R, Gordiyenko, Y, Robinson, C.V, Darst, S.A. 登録日 2008-05-09 公開日 2009-01-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda J.Mol.Biol., 386, 2009
4BL7	Crystal structure of the AIMP3-MRS N-terminal domain complex in different space group 分子名称: EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1, METHIONINE--TRNA LIGASE, CYTOPLASMIC 著者 Cho, H.Y, Seo, W.W, Cho, H.J, Kang, B.S. 登録日 2013-05-02 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.892 Å) 主引用文献 Crystal Structure of the Aimp3-Mrs N-Terminal Domain Complex in Different Space Group To be Published
5KLY	Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant adenosine nucleoside phosphoramidate substrate complex 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Histidine triad nucleotide-binding protein 1, ... 著者 Maize, K.M, Finzel, B.C. 登録日 2016-06-26 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017

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