PDB: 46200 件ウェブページステータス検索Chemie searchBIRD

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3UVP	Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone 分子名称: Mitogen-activated protein kinase 14, N-{2-fluoro-5-[(5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino]phenyl}benzamide, octyl beta-D-glucopyranoside 著者 Mayer-Wrangowski, S.C, Richters, A, Gruetter, C, Rauh, D. 登録日 2011-11-30 公開日 2012-11-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38 alpha Inhibitors. J.Med.Chem., 55, 2012
8DHB	Active FLCN GAP complex 分子名称: BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ... 著者 Jansen, R.M, Hurley, J.H. 登録日 2022-06-25 公開日 2022-09-28 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation. Sci Adv, 8, 2022
4I6J	A ubiquitin ligase-substrate complex 分子名称: Cryptochrome-2, F-box/LRR-repeat protein 3, S-phase kinase-associated protein 1 著者 Xing, W, Busino, L, Hinds, T.R, Marionni, S.T, Saifee, N.H, Bush, M.F, Pagano, M, Zheng, N. 登録日 2012-11-29 公開日 2013-03-13 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature, 496, 2013
6K9K	Monomeric human ATM (Ataxia telangiectasia mutated) kinase 分子名称: Serine-protein kinase ATM 著者 Xiao, J, Liu, M, Qi, Y, Yuriy, C, Zhang, P, Xu, Y. 登録日 2019-06-16 公開日 2019-12-25 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (7.82 Å) 主引用文献 Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
3UVR	Human p38 MAP Kinase in Complex with KM064 分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{3-[(5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino]phenyl}urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Richters, A, Mayer-Wrangowski, S.C, Gruetter, C, Rauh, D. 登録日 2011-11-30 公開日 2012-12-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献
1KPS	Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1 分子名称: Ran-GTPase activating protein 1, SULFATE ION, Ubiquitin-like protein SUMO-1 conjugating enzyme 著者 Bernier-Villamor, V, Sampson, D.A, Matunis, M.J, Lima, C.D. 登録日 2002-01-02 公開日 2002-02-13 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell(Cambridge,Mass.), 108, 2002
6ZHU	Yeast Uba1 in complex with Ubc3 and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ubiquitin-activating enzyme E1 1, ... 著者 Misra, M, Schindelin, H. 登録日 2020-06-23 公開日 2022-01-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system To Be Published
4L8M	Human p38 MAP kinase in complex with a Dibenzoxepinone 分子名称: Mitogen-activated protein kinase 14, N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl}amino)phenyl]benzamide, octyl beta-D-glucopyranoside 著者 Richters, A, Mayer-Wrangowski, S.C, Gruetter, C, Rauh, D. 登録日 2013-06-17 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood. J.Med.Chem., 56, 2013
2E1E	Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN 分子名称: CHLORIDE ION, Werner syndrome ATP-dependent helicase 著者 Kitano, K, Yoshihara, N, Hakoshima, T. 登録日 2006-10-25 公開日 2006-12-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the HRDC domain of human Werner syndrome protein, WRN J.Biol.Chem., 282, 2007
2EQG	Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 分子名称: Tumor necrosis factor, alpha-induced protein 3, ZINC ION 著者 Zhang, H.P, Hayahsi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-30 公開日 2007-10-02 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 To be published
6CPW	Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology 分子名称: (3S)-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-3-(methylsulfanyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 Hruza, A, Hruza, A. 登録日 2018-03-14 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg. Med. Chem. Lett., 28, 2018
3VU3	Crystal structure of the Hfq and catalase HPII complex 分子名称: Catalase HPII, PROTOPORPHYRIN IX CONTAINING FE, Protein hfq 著者 Watanabe, M, Yonekura, K. 登録日 2012-06-15 公開日 2013-11-20 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Post-Transcriptional Regulator Hfq Binds Catalase HPII: Crystal Structure of the Complex Plos One, 8, 2013
2VBW	Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Phenylalanine 分子名称: PHENYLALANINE, TRANSCRIPTIONAL REGULATORY PROTEIN 著者 Shrivastava, T, Ramachandran, R. 登録日 2007-09-18 公開日 2007-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mechanistic Insights from the Crystal Structures of a Feast/Famine Regulatory Protein from Mycobacterium Tuberculosis H37Rv. Nucleic Acids Res., 35, 2007
7KPF	NME2 bound to myristoyl-CoA 分子名称: GLYCEROL, MAGNESIUM ION, Nucleoside diphosphate kinase B, ... 著者 Price, I.R, Lin, H. 登録日 2020-11-11 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 A Chemical Proteomic Approach reveals the regulation of NME1/2 and cancer metastasis by Long-Chain Fatty Acyl Coenzyme A To Be Published
4KA3	Structure of MAP kinase in complex with a docking peptide 分子名称: Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 著者 Xin, F.J, Wu, J.W. 登録日 2013-04-22 公開日 2013-06-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.707 Å) 主引用文献 Crystal structure of the p38 alpha MAP kinase in complex with a docking peptide from TAB1 Sci China Life Sci, 56, 2013
2VC1	Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Methionine 分子名称: METHIONINE, TRANSCRIPTIONAL REGULATORY PROTEIN 著者 Shrivastava, T, Ramachandran, R. 登録日 2007-09-18 公開日 2007-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Mechanistic Insights from the Crystal Structures of a Feast/Famine Regulatory Protein from Mycobacterium Tuberculosis H37Rv. Nucleic Acids Res., 35, 2007
2VBZ	Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Tryptophan 分子名称: TRANSCRIPTIONAL REGULATORY PROTEIN, TRYPTOPHAN 著者 Shrivastava, T, Ramachandran, R. 登録日 2007-09-18 公開日 2007-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanistic Insights from the Crystal Structures of a Feast/Famine Regulatory Protein from Mycobacterium Tuberculosis H37Rv. Nucleic Acids Res., 35, 2007
2VBY	Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Tyrosine 分子名称: TRANSCRIPTIONAL REGULATORY PROTEIN, TYROSINE 著者 Shrivastava, T, Ramachandran, R. 登録日 2007-09-18 公開日 2007-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanistic Insights from the Crystal Structures of a Feast/Famine Regulatory Protein from Mycobacterium Tuberculosis H37Rv. Nucleic Acids Res., 35, 2007
3UVQ	Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative 分子名称: Mitogen-activated protein kinase 14, N-{5-[(7-{[(2R)-2,3-dihydroxypropyl]oxy}-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulen-2-yl)amino]-2-fluorophenyl}benzamide, octyl beta-D-glucopyranoside 著者 Mayer-Wrangowski, S.C, Richters, A, Gruetter, C, Rauh, D. 登録日 2011-11-30 公開日 2012-12-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J.Med.Chem., 56, 2013
4HSU	Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Xu, Y. 登録日 2012-10-30 公開日 2013-02-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.988 Å) 主引用文献 Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res., 23, 2013
4KIQ	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE 分子名称: Mitogen-activated protein kinase 14, ethyl 6-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]carbamoyl}-1H-indole-1-carboxylate 著者 Sack, J.S, Tokarski, J.S. 登録日 2013-05-02 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4DHX	ENY2:GANP complex 分子名称: 80 kDa MCM3-associated protein, Enhancer of yellow 2 transcription factor homolog 著者 Stewart, M, Jani, D. 登録日 2012-01-30 公開日 2012-06-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res., 40, 2012
2VBX	Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Phenylalanine 分子名称: HISTIDINE, TRANSCRIPTIONAL REGULATORY PROTEIN 著者 Shrivastava, T, Ramachandran, R. 登録日 2007-09-18 公開日 2007-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Mechanistic Insights from the Crystal Structures of a Feast/Famine Regulatory Protein from Mycobacterium Tuberculosis H37Rv. Nucleic Acids Res., 35, 2007
2EQF	Solution structure of the 7th A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 分子名称: Tumor necrosis factor, alpha-induced protein 3, ZINC ION 著者 Zhang, H.P, Hayahsi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-30 公開日 2007-10-02 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the 7th A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 To be Published
2EQE	Solution structure of the fourth A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 分子名称: Tumor necrosis factor, alpha-induced protein 3, ZINC ION 著者 Zhang, H.P, Nagasima, T, Hayahsi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-30 公開日 2007-10-02 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the fourth A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3 To be Published

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