PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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6PTV	Crystal structure of a DnaN sliding clamp (DNA polymerase III subunit beta) from Rickettsia rickettsii bound to griselimycin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACE-MVA-MP8-NZC-LEU-MP8-LEU-MVA-PRO-MLU-GLY, Beta sliding clamp 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-07-16 公開日 2019-08-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of a DnaN sliding clamp (DNA polymerase III subunit beta) from Rickettsia rickettsii bound to griselimycin To Be Published
4V8F	Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin). 分子名称: 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... 著者 Jenner, L, Demeshkina, N, Yusupov, M, Yusupova, G. 登録日 2011-12-07 公開日 2014-07-09 最終更新日 2019-07-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A new understanding of the decoding principle on the ribosome. Nature, 484, 2012
6H3U	Schmallenberg Virus Glycoprotein Gc Head Domain in Complex with scFv 4B6 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Envelopment polyprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Hellert, J, Aebischer, A, Wernike, K, Haouz, A, Brocchi, E, Reiche, S, Guardado-Calvo, P, Beer, M, Rey, F.A. 登録日 2018-07-19 公開日 2019-02-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.168 Å) 主引用文献 Orthobunyavirus spike architecture and recognition by neutralizing antibodies. Nat Commun, 10, 2019
7RAC	Crystal structure of a dodecameric multicopper oxidase from M. hydrothermalis in an orthorhombic lattice 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, COPPER (II) ION, ... 著者 Georgiadis, M.M, Ogata, C.M. 登録日 2021-06-30 公開日 2021-10-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Crystal structures of a dodecameric multicopper oxidase from Marinithermus hydrothermalis. Acta Crystallogr D Struct Biol, 77, 2021
6Q0D	CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00384414-01 AT 2.05 A RESOLUTION 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-[3-(cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... 著者 Dranow, D.M, Davies, D.R. 登録日 2019-08-01 公開日 2020-09-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
7RAB	Crystal structure of a dodecameric multicopper oxidase from M. hydrothermalis in a cubic lattice 分子名称: COPPER (II) ION, MAGNESIUM ION, multicopper oxidase 著者 Georgiadis, M.M. 登録日 2021-06-30 公開日 2021-10-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystal structures of a dodecameric multicopper oxidase from Marinithermus hydrothermalis. Acta Crystallogr D Struct Biol, 77, 2021
3K43	Crystal structure of sCD-MPR mutant E19Q/K137M pH 6.5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Cation-dependent mannose-6-phosphate receptor, ... 著者 Olson, L.J, Sun, G, Bohnsack, R.N, Peterson, F.C, Dahms, N.M, Kim, J.J.P. 登録日 2009-10-05 公開日 2009-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry, 49, 2010
6NNJ	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to CH31 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.1 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ... 著者 Lai, Y.-T, Kwong, P.D. 登録日 2019-01-15 公開日 2019-02-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Improvement of antibody functionality by structure-guided paratope engraftment. Nat Commun, 10, 2019
6Q2W	Crystal structure of human ROR gamma LBD in complex with a quinoline sulfonamide inverse agonist 分子名称: (2~{S})-1-[2,4-bis(chloranyl)-3-[[4-imidazol-1-yl-2-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]sulfonyl-~{N}-methyl-pyrrolidine-2-carboxamide, Nuclear receptor ROR-gamma 著者 Ciesielski, F, Amaudrut, J, Argiriadi, M.A, Barth, M, Breinlinger, E.C, Calderwood, D.J, Cusack, K.P, Kort, M.E, Montalbetti, C, Potin, D, Poupardin, O, Spitzer, L. 登録日 2018-12-03 公開日 2019-05-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active ROR gamma inverse agonists. Bioorg.Med.Chem.Lett., 29, 2019
6Q6O	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: CHOLIC ACID, Nuclear receptor ROR-gamma, propan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoate 著者 Kallen, J. 登録日 2018-12-11 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019
7T0W	Complex of GABA-A synaptic receptor with autoimmune antibody Fab115 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab115 Heavy Chain, IgG1, ... 著者 Noviello, C.M, Hibbs, R.E, Kreye, J, Teng, J, Pruss, H. 登録日 2021-11-30 公開日 2022-07-13 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mechanisms of GABA A receptor autoimmune encephalitis. Cell, 185, 2022
6PT1	Crystal Structure of Class D Beta-lactamase OXA-48 with Meropenem 分子名称: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, CHLORIDE ION, Class D Carbapenemase OXA-48, ... 著者 Akhtar, A, Chen, Y. 登録日 2019-07-14 公開日 2020-01-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
7QG4	Apo crystal structure of a mutant of SN243 (D415N) 分子名称: SN243, SULFATE ION, ZINC ION 著者 Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. 登録日 2021-12-07 公開日 2022-10-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
6Q7H	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 9 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: 1-[2,4-bis(chloranyl)-3-[2-(5-chloranylfuran-2-yl)-5-methyl-4-(trifluoromethyl)imidazol-1-yl]phenyl]azetidine-3-carboxylic acid, Nuclear receptor ROR-gamma 著者 Kallen, J. 登録日 2018-12-13 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019
7T0Z	Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab175 IgG1 heavy chain, ... 著者 Noviello, C.M, Hibbs, R.E, Kreye, J, Teng, J, Pruss, H. 登録日 2021-11-30 公開日 2022-07-13 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mechanisms of GABA A receptor autoimmune encephalitis. Cell, 185, 2022
6Q87	Structure of Fucosylated D-antimicrobial peptide SB10 in complex with the Fucose-binding lectin PA-IIL at 2.541 Angstrom resolution 分子名称: 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, AMINO GROUP, CALCIUM ION, ... 著者 Baeriswyl, S, Stocker, A, Reymond, J.-L. 登録日 2018-12-14 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.541 Å) 主引用文献 X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. Acs Chem.Biol., 14, 2019
6NJY	Type IV CRISPR associated RNA endonuclease Cas6 - apo form 分子名称: SULFATE ION, Type IV CRISPR associated Cas6 RNA endonuclease, beta-D-glucopyranose 著者 Jackson, R.N, Warner, E, Olsen, K.J. 登録日 2019-01-04 公開日 2019-07-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease. Rna Biol., 16, 2019
6XMR	X-ray crystallographic structure model of Lactococcus lactis prolidase mutant H38S 分子名称: Aminopeptidase P family protein, MANGANESE (II) ION 著者 Xu, S, Grochulski, P, Tanaka, T. 登録日 2020-06-30 公開日 2020-07-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystallographic structure of recombinant Lactococcus lactis prolidase to support proposed structure-function relationships. Biochim Biophys Acta Proteins Proteom, 1865, 2017
6XHX	Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. 登録日 2020-06-19 公開日 2020-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
6Q9H	HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 11 AT 2.0A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: (4~{S})-5-(3-chloranyl-2-fluoranyl-phenyl)-4-(4-chloranyl-2-methyl-phenyl)-3-propan-2-yl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one, E3 ubiquitin-protein ligase Mdm2 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6PYL	Crystal Structure of HLA-B*2703 in complex with KK10, an HIV peptide 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-27:03 alpha chain, ... 著者 Gras, S. 登録日 2019-07-30 公開日 2019-11-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation. J.Biol.Chem., 294, 2019
8C3P	Crystal structure of autotaxin gamma in complex with LPA 18:1 分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, 7alpha-hydroxycholesterol, CALCIUM ION, ... 著者 Eymery, M.C, McCarthy, A.A. 登録日 2022-12-28 公開日 2023-11-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids. Eur.J.Med.Chem., 263, 2023
6Q9Y	HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 16 AT 1.20A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: 7-methoxy-~{N}-[(3~{S})-1-(4-methylphenyl)pyrrolidin-3-yl]-1~{H}-indole-3-carboxamide, Protein Mdm4 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6DTS	Maltotetraose bound T. maritima MalE2 分子名称: alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltose-binding protein MalE2 著者 Cuneo, M.J, Shukla, S. 登録日 2018-06-18 公開日 2018-09-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Differential Substrate Recognition by Maltose Binding Proteins Influenced by Structure and Dynamics. Biochemistry, 57, 2018
4Y4O	Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... 著者 Polikanov, Y.S, Melnikov, S.V, Soll, D, Steitz, T.A. 登録日 2015-02-10 公開日 2015-03-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly. Nat.Struct.Mol.Biol., 22, 2015

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