PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4XOZ	Crystal structure of ERK2 in complex with an inhibitor 分子名称: Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION 著者 Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. 登録日 2015-01-16 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
4XRL	Crystal structure at room temperature of Erk2 in complex with an inhibitor 分子名称: 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, Mitogen-activated protein kinase 1, SULFATE ION 著者 Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. 登録日 2015-01-21 公開日 2016-03-23 最終更新日 2016-03-30 実験手法 X-RAY DIFFRACTION (2.554 Å) 主引用文献 Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
5KE0	Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers 分子名称: 1-[3-(2-methylpyridin-4-yl)-1~{H}-pyrazolo[4,3-c]pyridin-6-yl]-3-(phenylmethyl)urea, Mitogen-activated protein kinase 1, SULFATE ION 著者 Hruza, A, Lim, J. 登録日 2016-06-09 公開日 2016-07-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers. J.Med.Chem., 59, 2016
4XOY	Crystal structure of ERK2 in complex with an inhibitor 分子名称: 2-amino-1,9-dihydro-6H-purine-6-thione, Mitogen-activated protein kinase 1, SULFATE ION 著者 Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. 登録日 2015-01-16 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
4XP0	Crystal structure of ERK2 in complex with an inhibitor 分子名称: 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. 登録日 2015-01-16 公開日 2015-08-12 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
2IW6	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MAGNESIUM ION, ... 著者 Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M. 登録日 2006-06-26 公開日 2006-09-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity. J.Med.Chem., 49, 2006
4XRJ	Crystal structure of ERK2 in complex with an inhibitor 分子名称: Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION 著者 Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. 登録日 2015-01-21 公開日 2015-08-12 最終更新日 2015-08-19 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
2J9M	Crystal Structure of CDK2 in complex with Macrocyclic Aminopyrimidine 分子名称: 6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE, CELL DIVISION PROTEIN KINASE 2 著者 Schaefer, M, Luecking, U, Siemeister, G, Briem, H, Krueger, M, Lienau, P, Jautelat, R. 登録日 2006-11-13 公開日 2007-11-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Macrocyclic Aminopyrimidines as Multitarget Cdk and Vegf-R Inhibitors with Potent Antiproliferative Activities. Chemmedchem, 2, 2007
1LEZ	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B 分子名称: MAP kinase kinase 3b, MITOGEN-ACTIVATED PROTEIN KINASE 14 著者 Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. 登録日 2002-04-10 公開日 2002-07-10 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
4A8M	Non-Catalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial dsRNA virus phi6 from De Novo Initiation to Elongation 分子名称: 5'-D(*AP*AP*TP*CP)-3', ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Wright, S, Poranen, M.M, Bamford, D.H, Stuart, D.I, Grimes, J.M. 登録日 2011-11-21 公開日 2012-07-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Noncatalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial Double-Stranded RNA Virus Phi6 from De Novo Initiation to Elongation. J.Virol., 86, 2012
2EFR	Crystal structure of the c-terminal tropomyosin fragment with N- and C-terminal extensions of the leucine zipper at 1.8 angstroms resolution 分子名称: General control protein GCN4 and Tropomyosin 1 alpha chain 著者 Minakata, S, Nitanai, Y, Maeda, K, Oda, N, Wakabayashi, K, Maeda, Y. 登録日 2007-02-23 公開日 2008-03-04 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Two crystal structures of tropomyosin C-terminal fragment 176-273: exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule To be Published
4A8W	Non-Catalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial dsRNA virus phi6 from De Novo Initiation to Elongation 分子名称: 5'-D(*TP*TP*CP*GP*CP*GP*TP*AP*AP*GP*CP*GP)-3', ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Wright, S, Poranen, M.M, Bamford, D.H, Stuart, D.I, Grimes, J.M. 登録日 2011-11-21 公開日 2012-07-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 Noncatalytic Ions Direct the RNA-Dependent RNA Polymerase of Bacterial Double-Stranded RNA Virus Phi6 from De Novo Initiation to Elongation. J.Virol., 86, 2012
2CGN	FACTOR INHIBITING HIF-1 ALPHA with succinate 分子名称: FE (III) ION, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, SUCCINIC ACID, ... 著者 McDonough, M.A, Clifton, I.J, Schofield, C.J. 登録日 2006-03-09 公開日 2006-12-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282, 2007
2C9C	Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. 登録日 2005-12-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf. J.Mol.Biol., 357, 2006
4ID5	HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site 分子名称: 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, DIMETHYL SULFOXIDE, ... 著者 Bauman, J.D, Patel, D, Arnold, E. 登録日 2012-12-11 公開日 2013-02-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening. J.Med.Chem., 56, 2013
1RB6	ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TETRAGONAL FORM 分子名称: CHLORIDE ION, General control protein GCN4, POTASSIUM ION 著者 Holton, J, Alber, T. 登録日 2003-11-01 公開日 2004-01-13 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Automated protein crystal structure determination using ELVES. Proc.Natl.Acad.Sci.USA, 101, 2004
2C98	Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 分子名称: ADENOSINE-5'-DIPHOSPHATE, PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. 登録日 2005-12-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf. J.Mol.Biol., 357, 2006
2C99	Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. 登録日 2005-12-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf. J.Mol.Biol., 357, 2006
2C96	Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF 分子名称: ADENOSINE-5'-TRIPHOSPHATE, PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. 登録日 2005-12-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf. J.Mol.Biol., 357, 2006
3T6N	Crystal Structure of Transcriptional Regulator 分子名称: Transcriptional regulator 著者 Do, S.V, Bolla, J.R, Chen, X, Yu, E.W. 登録日 2011-07-28 公開日 2013-04-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.314 Å) 主引用文献 Crystal Structure of the Rv3066 Transcriptional Regulator from Mycobacterium tuberculosis To be Published
1LEW	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A 分子名称: Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A 著者 Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. 登録日 2002-04-10 公開日 2002-07-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
2IW9	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MAGNESIUM ION, ... 著者 Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M. 登録日 2006-06-27 公開日 2006-09-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity. J.Med.Chem., 49, 2006
2IW8	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MONOTHIOGLYCEROL, ... 著者 Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M. 登録日 2006-06-27 公開日 2006-09-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity. J.Med.Chem., 49, 2006
7FTL	Crystal Structure of human cyclic GMP-AMP synthase in complex with 8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid 分子名称: (2P)-8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION 著者 Leibrock, L, Benz, J, Groebke-Zbinden, K, Brunner, M, Rudolph, M.G. 登録日 2023-02-08 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
5IFE	Crystal structure of the human SF3b core complex 分子名称: PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... 著者 Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. 登録日 2016-02-25 公開日 2016-10-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol.Cell, 64, 2016

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