PDB: 35756 件ウェブページステータス検索Chemie searchBIRD

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1NUO	Two RTH Mutants with Impaired Hormone Binding 分子名称: Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID 著者 Huber, B.R, Sandler, B, West, B.L, Cunha-Lima, S.T, Nguyen, H.T, Apriletti, J.W, Baxter, J.D, Fletterick, R.J. 登録日 2003-01-31 公開日 2003-04-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Two resistance to thyroid hormone mutants with impaired hormone binding Mol.Endocrinol., 17, 2003
1EFL	HUMAN MALIC ENZYME IN A QUATERNARY COMPLEX WITH NAD, MG, AND TARTRONATE 分子名称: MAGNESIUM ION, MALIC ENZYME, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Yang, Z, Floyd, D.L, Loeber, G, Tong, L. 登録日 2000-02-09 公開日 2000-03-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of a closed form of human malic enzyme and implications for catalytic mechanism. Nat.Struct.Biol., 7, 2000
2B6B	Cryo EM structure of Dengue complexed with CRD of DC-SIGN 分子名称: CD209 antigen, envelope glycoprotein 著者 Pokidysheva, E, Zhang, Y, Battisti, A.J, Bator-Kelly, C.M, Chipman, P.R, Gregorio, G, Hendrickson, W.A, Kuhn, R.J, Rossmann, M.G. 登録日 2005-09-30 公開日 2006-03-07 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (25 Å) 主引用文献 Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN Cell(Cambridge,Mass.), 124, 2006
6I3J	Bilirubin oxidase from Myrothecium verrucaria in complex with ferricyanide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bilirubin oxidase, CHLORIDE ION, ... 著者 Svecova, L, Koval, T, Skalova, T, Kolenko, P, Duskova, J, Ostergaard, L.H, Dohnalek, J. 登録日 2018-11-06 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Trp-His covalent adduct in bilirubin oxidase is crucial for effective bilirubin binding but has a minor role in electron transfer. Sci Rep, 9, 2019
6IFD	Crystal Structure of CMP-N-acetylneuraminate Synthetase from Vibrio cholerae in complex with CDP and Mg2+. 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CMP-N-acetylneuraminate Synthetase, ... 著者 Bose, S, Subramanian, R. 登録日 2018-09-19 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and functional characterization of CMP-N-acetylneuraminate synthetase from Vibrio cholerae. Acta Crystallogr D Struct Biol, 75, 2019
5CG8	NgTET1 in complex with 5hmC DNA 分子名称: 2-OXOGLUTARIC ACID, DNA (5'-D(*AP*GP*AP*AP*TP*TP*CP*CP*GP*TP*TP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*(5HC)P*GP*GP*AP*AP*TP*TP*CP*T)-3'), ... 著者 Hashimoto, H, Pais, J.E, Dai, N, Zhang, X, Zheng, Y, Cheng, X. 登録日 2015-07-09 公開日 2015-09-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Res., 43, 2015
7BJL	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-142 分子名称: 14-3-3 protein sigma, 3-[(3~{S})-3-methoxypiperidin-1-yl]-4-nitro-benzaldehyde, Transcription factor p65 著者 Wolter, M, Ottmann, C. 登録日 2021-01-14 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BJW	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-154 分子名称: 14-3-3 protein sigma, 4-nitro-3-(4-oxidanylpiperidin-1-yl)benzaldehyde, Transcription factor p65 著者 Wolter, M, Ottmann, C. 登録日 2021-01-14 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
1KQY	Hevamine Mutant D125A/E127A/Y183F in Complex with Penta-NAG 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hevamine A, ... 著者 Rozeboom, H.J, Dijkstra, B.W. 登録日 2002-01-08 公開日 2002-01-23 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis. Eur.J.Biochem., 269, 2002
7BJF	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-069 分子名称: (5-methyl-2-nitro-phenyl) cyclobutanecarboxylate, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-14 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6IHB	Adeno-Associated Virus 2 in complex with AAVR 分子名称: Capsid protein VP1, Dyslexia-associated protein KIAA0319-like protein 著者 Lou, Z.Y, Zhang, R. 登録日 2018-09-29 公開日 2019-03-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Adeno-associated virus 2 bound to its cellular receptor AAVR. Nat Microbiol, 4, 2019
7BIQ	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-180 分子名称: 14-3-3 protein sigma, 4-[[(2~{R})-2-methyl-3,4-dihydro-2~{H}-quinolin-1-yl]sulfonyl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-13 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BKH	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-153 分子名称: 14-3-3 protein sigma, 4-nitro-3-[(3S)-3-oxidanylpiperidin-1-yl]benzaldehyde, Transcription factor p65 著者 Wolter, M, Ottmann, C. 登録日 2021-01-16 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
1KTB	The Structure of alpha-N-Acetylgalactosaminidase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ... 著者 Garman, S.C, Hannick, L, Zhu, A, Garboczi, D.N. 登録日 2002-01-15 公開日 2002-03-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases Structure, 10, 2002
7BI3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-179 分子名称: 14-3-3 protein sigma, 4-[(6-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-12 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
4TR8	Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa 分子名称: DNA polymerase III subunit beta, SODIUM ION 著者 Olieric, V, Burnouf, D, Ennifar, E, Wolff, P. 登録日 2014-06-15 公開日 2014-09-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins. J.Med.Chem., 57, 2014
7BA7	Cys-42-tethered stabilizer 9 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-[3,5-bis(chloranyl)phenoxy]-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
1KIR	FV MUTANT Y(A 50)S (VL DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME 分子名称: LYSOZYME, MONOCLONAL ANTIBODY D1.3 著者 Fields, B.A, Poljak, R.J, Mariuzza, R.A. 登録日 1996-10-23 公開日 1996-12-23 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme. Biochemistry, 35, 1996
7BIY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 分子名称: 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-13 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BA5	Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(4-fluoranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
5CLA	Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic site and a free nucleobase (100% product at 360 hours) 分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(ORP)P*AP*GP*TP*CP*CP*G)-3'), ... 著者 Mullins, E.A, Eichman, B.F. 登録日 2015-07-16 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.541 Å) 主引用文献 The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions. Nature, 527, 2015
3AUL	Crystal structure of wild-type Lys48-linked diubiquitin in an open conformation 分子名称: Polyubiquitin-C 著者 Hirano, T, Olivier, S, Yagi, M, Takemoto, E, Hiromoto, T, Satoh, T, Mizushima, T, Kato, K. 登録日 2011-02-09 公開日 2011-09-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Conformational dynamics of wild-type Lys48-linked diubiquitin in solution J.Biol.Chem., 286, 2011
1XW3	Crystal Structure of Human Sulfiredoxin (Srx) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, SULFIREDOXIN 著者 Murray, M.S, Jonsson, T.J, Johnson, L.C, Poole, L.B, Lowther, W.T. 登録日 2004-10-29 公開日 2005-05-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. Biochemistry, 44, 2005
1FGR	LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697E MUTANT 分子名称: FE (III) ION, SEED LIPOXYGENASE-1 著者 Tomchick, D.R, Minor, W, Holman, T. 登録日 2000-07-28 公開日 2001-07-04 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1. Biochemistry, 40, 2001
6FZZ	Crystal structure of BSE31 (BSPA14S_RS05060 gene product) from Lyme disease agent Borrelia (Borreliella) spielmanii 分子名称: TETRAETHYLENE GLYCOL, Virulent strain associated lipoprotein 著者 Brangulis, K, Akopjana, I, Kazaks, A, Tars, K. 登録日 2018-03-15 公開日 2019-03-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 BBE31 from the Lyme disease agent Borrelia burgdorferi, known to play an important role in successful colonization of the mammalian host, shows the ability to bind glutathione. Biochim Biophys Acta Gen Subj, 1864, 2019

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