7K38
 
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7K2Z
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3D7B
 | | The Ribonuclease A- 5'-Deoxy-5'-N-pyrrolidinouridine complex | | 分子名称: | 1-(5-deoxy-5-pyrrolidin-1-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione, CITRATE ANION, Ribonuclease pancreatic | | 著者 | Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G. | | 登録日 | 2008-05-21 | | 公開日 | 2009-02-10 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.
J.Med.Chem., 52, 2009
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1B34
 | | CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN | | 分子名称: | PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1), PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2) | | 著者 | Walke, S, Young, R.J, Kambach, C, Avis, J.M, De La Fortelle, E, Li, J, Nagai, K. | | 登録日 | 1998-12-17 | | 公開日 | 2000-01-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
Cell(Cambridge,Mass.), 96, 1999
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2XX3
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2L2N
 | | Backbone 1H, 13C, and 15N Chemical Shift Assignments for the first dsRBD of protein HYL1 | | 分子名称: | Hyponastic leave 1 | | 著者 | Rasia, R.M, Mateos, J.L, Bologna, N.G, Burdisso, P, Imbert, L, Palatnik, J.F, Boisbouvier, J. | | 登録日 | 2010-08-23 | | 公開日 | 2010-09-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and RNA Interactions of the Plant MicroRNA Processing-Associated Protein HYL1.
Biochemistry, 49, 2010
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2L2M
 | | Solution structure of the second dsRBD of HYL1 | | 分子名称: | Hyponastic leave 1 | | 著者 | Rasia, R.M, Mateos, J.L, Bologna, N.G, Burdisso, P, Imbert, L, Palatnik, J.F, Boisbouvier, J. | | 登録日 | 2010-08-22 | | 公開日 | 2010-09-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and RNA Interactions of the Plant MicroRNA Processing-Associated Protein HYL1.
Biochemistry, 49, 2010
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2BND
 | | The structure of E. coli UMP kinase in complex with UDP | | 分子名称: | GLYCEROL, PYROPHOSPHATE 2-, URIDINE-5'-DIPHOSPHATE, ... | | 著者 | Briozzo, P, Evrin, C, Meyer, P, Assairi, L, Joly, N, Barzu, O, Gilles, A.M. | | 登録日 | 2005-03-23 | | 公開日 | 2005-04-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of Escherichia Coli Ump Kinase Differs from that of Other Nucleoside Monophosphate Kinases and Sheds New Light on Enzyme Regulation.
J.Biol.Chem., 280, 2005
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6J6G
 | | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | | 分子名称: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | 登録日 | 2019-01-15 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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4EL5
 | | Crystal structure of GPb in complex with DK12 | | 分子名称: | 5-ethynyl-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form | | 著者 | Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2012-04-10 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment.
Eur.J.Med.Chem., 54, 2012
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4EJ2
 | | Crystal structure of GPb in complex with DK10 | | 分子名称: | 1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form | | 著者 | Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2012-04-06 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment.
Eur.J.Med.Chem., 54, 2012
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7YI3
 | | Cryo-EM structure of Rpd3S in close-state Rpd3S-NCP complex | | 分子名称: | Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... | | 著者 | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | | 登録日 | 2022-07-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
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7YI2
 | | Cryo-EM structure of Rpd3S in loose-state Rpd3S-NCP complex | | 分子名称: | Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... | | 著者 | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | | 登録日 | 2022-07-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
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7YI0
 | | Cryo-EM structure of Rpd3S complex | | 分子名称: | Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... | | 著者 | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | | 登録日 | 2022-07-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
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3WGC
 | | Aeromonas jandaei L-allo-threonine aldolase H128Y/S292R double mutant | | 分子名称: | L-allo-threonine aldolase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE] | | 著者 | Qin, H.M, Imai, F.L, Miyakawa, T, Kataoka, M, Okai, M, Ohtsuka, J, Hou, F, Nagata, K, Shimizu, S, Tanokura, M. | | 登録日 | 2013-08-03 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | L-allo-Threonine aldolase with an H128Y/S292R mutation from Aeromonas jandaei DK-39 reveals the structural basis of changes in substrate stereoselectivity.
Acta Crystallogr.,Sect.D, 70, 2014
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4EKE
 | | Crystal structure of GPb in complex with DK11 | | 分子名称: | 3-(beta-D-glucopyranosyl)-6-pentylfuro[2,3-d]pyrimidin-2(3H)-one, Glycogen phosphorylase, muscle form | | 著者 | Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2012-04-09 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment.
Eur.J.Med.Chem., 54, 2012
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2N6T
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2N6X
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7AP4
 | | Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA | | 分子名称: | (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid, Aspartate--tRNA(Asp) ligase | | 著者 | De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2020-10-15 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
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7AP3
 | | Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA | | 分子名称: | SODIUM ION, Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate | | 著者 | De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2020-10-15 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
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7AP1
 | | Klebsiella pneumoniae Seryl-tRNA synthetase in Complex with Compound SerS7HMDDA | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Serine-tRNA ligase, ... | | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2020-10-15 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
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1E0Y
 | | Structure of the D170S/T457E double mutant of vanillyl-alcohol oxidase | | 分子名称: | ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL, FLAVIN-ADENINE DINUCLEOTIDE, VANILLYL-ALCOHOL OXIDASE | | 著者 | Van Der heuvel, R.H.H, Van Berkel, W.J.H, Mattevi, A. | | 登録日 | 2000-04-11 | | 公開日 | 2000-04-12 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Inversion of Stereospecificity in Vanillyl-Alcohol Oxidase
Proc.Natl.Acad.Sci.USA, 97, 2000
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2OG7
 | | Cystal structure of asparagine oxygenase in complex with Fe(II), 2S,3S-3-hydroxyasparagine and succinate | | 分子名称: | BETA-HYDROXYASPARAGINE, FE (II) ION, SUCCINIC ACID, ... | | 著者 | Essen, L.-O, Strieker, M. | | 登録日 | 2007-01-05 | | 公開日 | 2007-03-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide
Acs Chem.Biol., 2, 2007
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5CZB
 | | HCV NS5B IN COMPLEX WITH LIGAND IDX17119-5 | | 分子名称: | 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pierra, C, Dousson, C, Augustin, M. | | 登録日 | 2015-07-31 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Bioorg.Med.Chem.Lett., 26, 2016
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7ZI4
 | | Cryo-EM structure of the human INO80 complex bound to a WT nucleosome | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Vance, N.R, Ayala, R, Willhoft, O, Tvardovskiy, A, McCormack, E.A, Bartke, T, Zhang, X, Wigley, D.B. | | 登録日 | 2022-04-07 | | 公開日 | 2023-04-19 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
To Be Published
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