2FBW
| Avian respiratory complex II with carboxin bound | 分子名称: | (~{Z})-2-oxidanylbut-2-enedioic acid, 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE, AZIDE ION, ... | 著者 | Huang, L.S, Sun, G, Cobessi, D, Wang, A.C, Shen, J.T, Tung, E.Y, Anderson, V.E, Berry, E.A. | 登録日 | 2005-12-10 | 公開日 | 2005-12-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem., 281, 2006
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2D24
| Crystal structure of ES complex of catalytic-site mutant xylanase from Streptomyces olivaceoviridis E-86 | 分子名称: | ENDO-1,4-BETA-D-XYLANASE, GLYCEROL, SULFATE ION, ... | 著者 | Suzuki, R, Kuno, A, Fujimoto, Z, Ito, S, Kawahara, S.I, Kaneko, S, Hasegawa, T, Taira, K. | 登録日 | 2005-09-02 | 公開日 | 2006-10-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86 J.Biochem., 146, 2009
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7YFY
| Cryo-EM structure of the Mili-piRNA- target ternary complex | 分子名称: | MAGNESIUM ION, Piwi-like protein 2, RNA (5'-R(P*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ... | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-09 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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7YG6
| Cryo-EM structure of the EfPiwi(N959K) in complex with piRNA | 分子名称: | MAGNESIUM ION, Piwi, piRNA | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-11 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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7YGN
| Cryo-EM structure of the Mili in complex with piRNA | 分子名称: | MAGNESIUM ION, Piwi-like protein 2, piRNA | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-11 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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7YFX
| Cryo-EM structure of Hili in complex with piRNA | 分子名称: | MAGNESIUM ION, Piwi-like protein 2, piRNA | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-09 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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7YFQ
| Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex | 分子名称: | MAGNESIUM ION, Piwi, RNA (5'-R(*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ... | 著者 | Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. | 登録日 | 2022-07-08 | 公開日 | 2024-02-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
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4U7E
| The crystal structure of the complex of LIP5 NTD and IST1 MIM | 分子名称: | IST1 homolog, Vacuolar protein sorting-associated protein VTA1 homolog | 著者 | Guo, E.Z, Xu, Z. | 登録日 | 2014-07-30 | 公開日 | 2015-02-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains. J.Biol.Chem., 290, 2015
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391D
| STRUCTURAL VARIABILITY AND NEW INTERMOLECULAR INTERACTIONS OF Z-DNA IN CRYSTALS OF D(PCPGPCPGPCPG) | 分子名称: | DNA (5'-D(P*CP*GP*CP*GP*CP*G)-3') | 著者 | Malinina, L, Tereshko, V, Ivanova, E, Subirana, J.A, Zarytova, V, Nekrasov, Y. | 登録日 | 1998-04-20 | 公開日 | 1998-05-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural variability and new intermolecular interactions of Z-DNA in crystals of d(pCpGpCpGpCpG). Biophys.J., 74, 1998
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6BST
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392D
| STRUCTURAL VARIABILITY AND NEW INTERMOLECULAR INTERACTIONS OF Z-DNA IN CRYSTALS OF D(PCPGPCPGPCPG) | 分子名称: | DNA (5'-D(P*CP*GP*CP*GP*CP*G)-3'), MAGNESIUM ION | 著者 | Malinina, L, Tereshko, V, Ivanova, E, Subirana, J.A, Zarytova, V, Nekrasov, Y. | 登録日 | 1998-04-20 | 公開日 | 1998-05-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural variability and new intermolecular interactions of Z-DNA in crystals of d(pCpGpCpGpCpG). Biophys.J., 74, 1998
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8QQB
| Crystal structure of protein kinase CK2 catalytic subunit in complex with a Dibromo Dihydro Dibenzofuranone derivative | 分子名称: | (4~{Z})-7,9-bis(bromanyl)-8-oxidanyl-4-(phenylazanylmethylidene)-1,2-dihydrodibenzofuran-3-one, 1,2-ETHANEDIOL, Casein kinase II subunit alpha, ... | 著者 | Werner, C, Niefind, K, Jose, J. | 登録日 | 2023-10-04 | 公開日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Discovery of 7,9-Dibromo Dihydrodibenzofuran as Potent and Highly Selective CK2 inhibitor: Synthesis, Biological Evaluation and Structural Studies on E-/Z isomers To be published
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7DLX
| crystal structure of H2AM4>Z-H2B | 分子名称: | Histone H2B,Histone H2A | 著者 | Dai, L.C, Zhou, Z. | 登録日 | 2020-11-30 | 公開日 | 2021-06-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange. Cell Rep, 35, 2021
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2CBN
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390D
| STRUCTURAL VARIABILITY AND NEW INTERMOLECULAR INTERACTIONS OF Z-DNA IN CRYSTALS OF D(PCPGPCPGPCPG) | 分子名称: | DNA (5'-D(P*CP*GP*CP*GP*CP*G)-3') | 著者 | Malinina, L, Tereshko, V, Ivanova, E, Subirana, J.A, Zarytova, V, Nekrasov, Y. | 登録日 | 1998-04-20 | 公開日 | 1998-05-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural variability and new intermolecular interactions of Z-DNA in crystals of d(pCpGpCpGpCpG). Biophys.J., 74, 1998
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3P4J
| Ultra-high resolution structure of d(CGCGCG)2 Z-DNA | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), SPERMINE | 著者 | Brzezinski, K, Brzuszkiewicz, A, Dauter, M, Kubicki, M, Jaskolski, M, Dauter, Z. | 登録日 | 2010-10-06 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (0.55 Å) | 主引用文献 | High regularity of Z-DNA revealed by ultra high-resolution crystal structure at 0.55 A. Nucleic Acids Res., 39, 2011
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3F1S
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6Q4K
| CDK2 in complex with FragLite38 | 分子名称: | (~{E})-3-[3-[(4-chlorophenyl)carbamoyl]phenyl]prop-2-enoic acid, 1,2-ETHANEDIOL, Cyclin-dependent kinase 2 | 著者 | Wood, D.J, Martin, M.P, Noble, M.E.M. | 登録日 | 2018-12-05 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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5RHC
| PanDDA analysis group deposition SARS-CoV-2 main protease fragment screen -- Crystal Structure of SARS-CoV-2 main protease in complex with Cov_HetLib053 (Mpro-x2119) | 分子名称: | (E)-1-(1H-imidazol-2-yl)methanimine, 3C-like proteinase, DIMETHYL SULFOXIDE | 著者 | Fearon, D, Owen, C.D, Douangamath, A, Lukacik, P, Powell, A.J, Strain-Damerell, C.M, Resnick, E, Krojer, T, Gehrtz, P, Wild, C, Aimon, A, Brandao-Neto, J, Carbery, A, Dunnett, L, Skyner, R, Snee, M, Keeley, A, Keseru, G.M, London, N, Walsh, M.A, von Delft, F. | 登録日 | 2020-05-16 | 公開日 | 2020-06-10 | 最終更新日 | 2021-02-24 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nat Commun, 11, 2020
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5RHB
| PanDDA analysis group deposition SARS-CoV-2 main protease fragment screen -- Crystal Structure of SARS-CoV-2 main protease in complex with Cov_HetLib030 (Mpro-x2097) | 分子名称: | (E)-1-(pyrimidin-2-yl)methanimine, 3C-like proteinase, DIMETHYL SULFOXIDE | 著者 | Fearon, D, Owen, C.D, Douangamath, A, Lukacik, P, Powell, A.J, Strain-Damerell, C.M, Resnick, E, Krojer, T, Gehrtz, P, Wild, C, Aimon, A, Brandao-Neto, J, Carbery, A, Dunnett, L, Skyner, R, Snee, M, Keeley, A, Keseru, G.M, London, N, Walsh, M.A, von Delft, F. | 登録日 | 2020-05-16 | 公開日 | 2020-06-10 | 最終更新日 | 2021-02-24 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nat Commun, 11, 2020
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7STZ
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7AA0
| Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands | 分子名称: | (~{E})-3-[4-(4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinolin-6-yl)phenyl]prop-2-enoic acid, Cellular retinoic acid-binding protein 2 | 著者 | Tomlinson, C.W.E, Cornish, K.A.S, Pohl, E. | 登録日 | 2020-09-02 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Structure-functional relationship of cellular retinoic acid-binding proteins I and II interacting with natural and synthetic ligands. Acta Crystallogr D Struct Biol, 77, 2021
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8BO6
| COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 2 | 分子名称: | (~{E})-~{N}-[[5-(3-azanyl-1~{H}-indazol-6-yl)-4-chloranyl-1~{H}-imidazol-2-yl]methyl]-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enamide, CITRIC ACID, Coagulation factor XIa light chain, ... | 著者 | Schaefer, M, Roehrig, S, Ackerstaff, J, Nunez, E.J, Gericke, K.M, Meier, K, Tersteegen, A, Stampfuss, J, Ellerbrock, P, Meibom, D, Lang, D, Heitmeier, S, Hillisch, A. | 登録日 | 2022-11-14 | 公開日 | 2023-09-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders. J.Med.Chem., 66, 2023
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6RCM
| Human protein kinase CK2 alpha in complex with 2-cyano-2-propenamide compound 3 | 分子名称: | (~{E})-~{N}-(5-~{tert}-butyl-1,3,4-thiadiazol-2-yl)-2-cyano-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide, 1,2-ETHANEDIOL, Casein kinase II subunit alpha, ... | 著者 | Dalle Vedove, A, Zanforlin, E, Ribaudo, G, Zagotto, G, Battistutta, R, Lolli, G. | 登録日 | 2019-04-11 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur.J.Med.Chem., 195, 2020
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6RFE
| Human protein kinase CK2 alpha in complex with 2-cyano-2-propenamide compound 4 | 分子名称: | (~{E})-~{N}-(5-bromanyl-1,3,4-thiadiazol-2-yl)-2-cyano-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enamide, 1,2-ETHANEDIOL, Casein kinase II subunit alpha, ... | 著者 | Dalle Vedove, A, Zanforlin, E, Ribaudo, G, Zagotto, G, Battistutta, R, Lolli, G. | 登録日 | 2019-04-13 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur.J.Med.Chem., 195, 2020
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