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PDB: 19 件
5A7G
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Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, LIVER CARBOXYLESTERASE 1
著者Arena de Souza, V, Scott, D.J, Charlton, M, Walsh, M.A, Owen, R.J.
登録日2015-07-04
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.
Plos One, 10, 2015
5A7F
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Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, LIVER CARBOXYLESTERASE 1, PHOSPHATE ION
著者Arena de Souza, V, Scott, D.J, Charlton, M, Walsh, M.A, Owen, R.J.
登録日2015-07-03
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.
Plos One, 10, 2015
2H7C
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Crystal structure of human carboxylesterase in complex with Coenzyme A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COENZYME A, ...
著者Bencharit, S, Edwards, C.C, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
5A7H
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Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1
分子名称: IODIDE ION, LIVER CARBOXYLESTERASE 1
著者Arena de Souza, V, Scott, D.J, Charlton, M, Walsh, M.A, Owen, R.J.
登録日2015-07-04
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.
Plos One, 10, 2015
4AB1
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Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, LIVER CARBOXYLESTERASE 1, THIOCYANATE ION
著者Greenblatt, H.M, Otto, T.C, Cerasoli, D.M, Sussman, J.L.
登録日2011-12-06
公開日2012-03-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae.
Acta Crystallogr.,Sect.F, 68, 2012
1MX1
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Crystal Structure of Human Liver Carboxylesterase in complex with tacrine
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid, ...
著者Bencharit, S, Morton, C.L, Hyatt, J.L, Kuhn, P, Danks, M.K, Potter, P.M, Redinbo, M.R.
登録日2002-10-01
公開日2003-04-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: From Binding Promiscuity to Selective Inhibition
CHEM.BIOL., 10, 2003
8EOR
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Liver carboxylesterase 1
分子名称: ETHYL ACETATE, Liver carboxylesterase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zhang, Z, Yu, E.
登録日2022-10-04
公開日2023-05-03
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.67 Å)
主引用文献High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
2HRR
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Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, N-acetyl-alpha-neuraminic acid, ...
著者Fleming, C.D, Redinbo, M.R.
登録日2006-07-20
公開日2007-05-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
2HRQ
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Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD)
分子名称: (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, ...
著者Fleming, C.D, Redinbo, M.R.
登録日2006-07-20
公開日2007-05-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
2DQZ
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Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COENZYME A, FLUORIDE ION, ...
著者Bencharit, S, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
1MX5
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Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, HOMOTROPINE, ...
著者Bencharit, S, Morton, C.L, Xue, Y, Potter, P.M, Redinbo, M.R.
登録日2002-10-01
公開日2003-04-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis of Heroin and Cocaine Metabolism by a Promiscuous Human Drug-Processing Enzyme
Nat.Struct.Biol., 10, 2003
1MX9
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Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue
分子名称: (5A,17R)-4,5-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXO-17-(2-PROPENYL)-MORPHINANIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, liver Carboxylesterase I
著者Bencharit, S, Morton, C.L, Xue, Y, Potter, P.M, Redinbo, M.R.
登録日2002-10-01
公開日2003-04-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis of Heroin and Cocaine Metabolism by a Promiscuous Human Drug-Processing Enzyme
Nat.Struct.Biol., 10, 2003
2DQY
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Crystal structure of human carboxylesterase in complex with cholate and palmitate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLIC ACID, Liver carboxylesterase 1, ...
著者Bencharit, S, Edwards, C.C, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
1YA8
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Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin
分子名称: (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL, 2-METHYLBUTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2004-12-17
公開日2005-08-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YAH
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Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CES1 protein, ETHYL ACETATE, ...
著者Fleming, C.D, Bencahrit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2004-12-17
公開日2005-08-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
3K9B
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Crystal structure of human liver carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF)
分子名称: Liver carboxylesterase 1, cyclohexyl (S)-methylphosphonofluoridoate
著者Hemmert, A.C, Redinbo, M.R.
登録日2009-10-15
公開日2010-01-19
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.
Mol.Pharmacol., 77, 2010
2DR0
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Crystal structure of human carboxylesterase in complex with taurocholate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, N-acetyl-alpha-neuraminic acid, ...
著者Bencharit, S, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
1YA4
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Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen
分子名称: (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CES1 protein, ...
著者Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2004-12-17
公開日2005-08-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005
1YAJ
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Crystal Structure of Human Liver Carboxylesterase in complex with benzil
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZOIC ACID, CES1 protein, ...
著者Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.M, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2004-12-17
公開日2005-08-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
J.Mol.Biol., 352, 2005

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