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PDB: 377 件
3REW
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BU of 3rew by Molmil
Crystal structure of an lmp2a-derived peptide bound to human class i mhc hla-a2
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ...
著者Wood, A, Mohammed, F, Salim, M, Tranter, A, Rickinson, A.B, Moss, P.A.H, Stauss, H.J, Steven, N.M, Willcox, B.E.
登録日2011-04-05
公開日2012-01-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.
Proc.Natl.Acad.Sci.USA, 108, 2011
1T1Z
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BU of 1t1z by Molmil
Structural basis for degenerate recognition of HIV peptide variants by cytotoxic lymphocyte, variant SL9-6A
分子名称: Beta-2-microglobulin, GAG PEPTIDE, HLA class I histocompatibility antigen, ...
著者Martinez-Hackert, E, Anikeeva, N, Kalams, S.A, Walker, B.D, Hendrickson, W.A, Sykulev, Y.
登録日2004-04-19
公開日2005-09-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Degenerate Recognition of Natural HIV Peptide Variants by Cytotoxic Lymphocytes.
J.Biol.Chem., 281, 2006
4JFQ
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BU of 4jfq by Molmil
A2 HLA complex with L8A heteroclitic variant of Melanoma peptide
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, GLYCEROL, ...
著者Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M.
登録日2013-02-28
公開日2013-05-29
最終更新日2013-07-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
1HSB
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BU of 1hsb by Molmil
DIFFERENT LENGTH PEPTIDES BIND TO HLA-AW68 SIMILARLY AT THEIR ENDS BUT BULGE OUT IN THE MIDDLE
分子名称: ALANINE, ARGININE, BOUND PEPTIDE FRAGMENT, ...
著者Guo, H.-C, Strominger, J.L, Wiley, D.C.
登録日1993-03-30
公開日1993-10-31
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle.
Nature, 360, 1992
3O3B
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BU of 3o3b by Molmil
Human Class I MHC HLA-A2 in complex with the Peptidomimetic ELA-1.1
分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
著者Borbulevych, O.Y, Baker, B.M.
登録日2010-07-23
公開日2010-12-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of HLA-A*0201 complexed with Melan-A/MART-1(26(27L)-35) peptidomimetics reveal conformational heterogeneity and highlight degeneracy of T cell recognition.
J.Med.Chem., 53, 2010
6PTE
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BU of 6pte by Molmil
Crystal Structure of ILNAMITKI peptide bound to HLA-A2
分子名称: Beta-2-microglobulin, GLYCEROL, HAUS augmin-like complex subunit 3, ...
著者Smith, A.R, Arbuiso, A, Keller, G.L.J, Baker, B.M.
登録日2019-07-15
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Structure Based Prediction of Neoantigen Immunogenicity.
Front Immunol, 10, 2019
4JFP
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BU of 4jfp by Molmil
A2 HLA complex with G4A heteroclitic variant of Melanoma peptide
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ...
著者Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K.
登録日2013-02-28
公開日2013-05-29
最終更新日2013-07-17
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
3FQW
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BU of 3fqw by Molmil
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
分子名称: Beta-2-microglobulin, CADMIUM ION, COBALT (II) ION, ...
著者Petersen, J, Rossjohn, J.
登録日2009-01-07
公開日2009-03-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.927 Å)
主引用文献Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106, 2009
3MR9
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BU of 3mr9 by Molmil
Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503 nonapeptide M5A variant
分子名称: 9-meric peptide from Tegument protein pp65, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Reiser, J.-B, Le Gorrec, M, Chouquet, A, Debeaupuis, E, Echasserieau, K, Saulquin, X, Bonneville, M, Housset, D.
登録日2010-04-29
公開日2011-05-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal Structure of MHC class I HLA-A2 molecule complexed with short peptide
To be Published
5GRG
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BU of 5grg by Molmil
Crystal structure of dual peptide from EBV in complex with HLA-A*11:01
分子名称: Beta-2-microglobulin, Epstein Barr Virus, Latent Membrane Protein 2 epitope, ...
著者Tadwal, V.S, Xiao, Z, Ren, E.C.
登録日2016-08-11
公開日2017-08-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
4E5X
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BU of 4e5x by Molmil
Crystal structure of a complex between the human adenovirus type 2 E3-19K protein and MHC class I molecule HLA-A2/Tax
分子名称: Beta-2-microglobulin, Early E3 18.5 kDa glycoprotein, HLA class I histocompatibility antigen, ...
著者Li, L, Bouvier, M.
登録日2012-03-14
公開日2012-10-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation.
Nat.Struct.Mol.Biol., 19, 2012
3FT3
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BU of 3ft3 by Molmil
Crystal Structure of the minor histocompatibility peptide HA-1His in complex with HLA-A2
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Reiser, J.-B, Gras, S, Chouquet, A, Le Gorrec, M, Spierings, E, Goulmy, E, Housset, D.
登録日2009-01-12
公開日2009-04-28
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.
J.Immunol., 182, 2009
3GSR
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BU of 3gsr by Molmil
Crystal structure of the binary complex between HLA-A2 and HCMV NLV-M5V peptide variant
分子名称: Beta-2-microglobulin, HCMV pp65 fragment 495-503, variant M5V (NLVPVVATV), ...
著者Reiser, J.-B, Saulquin, X, Gras, S, Debeaupuis, E, Echasserieau, K, Kissenpfennig, A, Legoux, F, Chouquet, A, Le Gorrec, M, Machillot, P, Neveu, B, Thielens, N, Malissen, B, Bonneville, M, Housset, D.
登録日2009-03-27
公開日2009-08-04
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.
J.Immunol., 183, 2009
3VXN
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BU of 3vxn by Molmil
HLA-A24 in complex with HIV-1 Nef134-10(wt)
分子名称: 10-mer peptide from Protein Nef, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Shimizu, A, Fukai, S, Yamagata, A, Iwamoto, A.
登録日2012-09-20
公開日2013-10-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
SCI REP, 3, 2013
2AV1
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BU of 2av1 by Molmil
Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain.
分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
著者Borbulevych, O.Y, Baker, B.M.
登録日2005-08-29
公開日2005-10-18
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants.
J.Mol.Biol., 353, 2005
7UC5
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BU of 7uc5 by Molmil
Crystal Structure of HLA A*0301 in complex with ILRGSVAHK, a 9-mer epitope from Influenza A
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ...
著者Gras, S, Nguyen, A.T, Szeto, C.
登録日2022-03-16
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献CD8+ T cells cross-recognise conserved influenza A and B homologous epitopes
to be published
7L1C
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BU of 7l1c by Molmil
Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide
分子名称: Beta-2-microglobulin, FORMIC ACID, GLYCEROL, ...
著者Ma, J, Baker, B.M.
登録日2020-12-14
公開日2022-03-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
Nat Med, 28, 2022
5EU3
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BU of 5eu3 by Molmil
HLA Class I antigen
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
著者Rizkallah, P.J, Bianchi, V, Cole, D.K, Sewell, A.K.
登録日2015-11-18
公開日2016-03-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.
J.Biol.Chem., 291, 2016
5C0C
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BU of 5c0c by Molmil
1E6 TCR in complex with HLA-A02 carrying RQFGPDWIVA
分子名称: 1,2-ETHANEDIOL, 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, ...
著者Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K.
登録日2015-06-12
公開日2016-05-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.974 Å)
主引用文献Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J.Clin.Invest., 126, 2016
6E1I
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BU of 6e1i by Molmil
HLA-A*0201 single chain trimer with murine H2K alpha 3 domain and HPV.16 E7 peptide YMLDLQPET
分子名称: HLA-A*0201 single chain trimer with murine H2K alpha 3 domain and HPV.16 E7 peptide YMLDLQPET
著者Finton, K.A.K, Rusnac, D.V.
登録日2018-07-09
公開日2019-07-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Effects of HLA single chain trimer design on peptide presentation and stability
To Be Published
1LP9
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BU of 1lp9 by Molmil
Xenoreactive complex AHIII 12.2 TCR bound to p1049/HLA-A2.1
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Buslepp, J, Wang, H, Biddison, W.E, Appella, E, Collins, E.J.
登録日2002-05-07
公開日2003-11-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
Immunity, 19, 2003
4NQX
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BU of 4nqx by Molmil
Crystal Structure of HLA A*0101 in complex with NP44-S7N, an 9-mer influenza epitope
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-1 alpha chain, ...
著者Rossjohn, J, Gras, S.
登録日2013-11-26
公開日2013-12-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NO2
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BU of 4no2 by Molmil
Crystal structure of RQA_V phosphopeptide bound to HLA-A2
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Mohammed, F, Stones, D.H, Willcox, B.E.
登録日2013-11-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.
Oncotarget, 8, 2017
2X70
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BU of 2x70 by Molmil
Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, GLYCEROL, ...
著者Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M.
登録日2010-02-22
公開日2010-12-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Uv-Induced Ligand Exchange in Mhc Class I Protein Crystals.
J.Am.Chem.Soc., 131, 2009
3HPJ
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BU of 3hpj by Molmil
Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) peptide
分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
著者Borbulevych, O.Y, Baker, B.M.
登録日2009-06-04
公開日2010-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: Implications for WT1-based cancer therapeutics.
Mol.Immunol., 47, 2010

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