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PDB: 7 件

3PB6
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BU of 3pb6 by Molmil
Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.5
分子名称: CACODYLATE ION, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
著者Huang, K.F, Liaw, S.S, Huang, W.L, Chia, C.Y, Lo, Y.C, Chen, Y.L, Wang, A.H.J.
登録日2010-10-20
公開日2011-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
J.Biol.Chem., 286, 2011
3PB9
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BU of 3pb9 by Molmil
Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase in complex with 1-benzylimidazole
分子名称: 1-BENZYL-1H-IMIDAZOLE, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
著者Huang, K.F, Liaw, S.S, Huang, W.L, Chia, C.Y, Lo, Y.C, Chen, Y.L, Wang, A.H.J.
登録日2010-10-20
公開日2011-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
J.Biol.Chem., 286, 2011
3PB4
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BU of 3pb4 by Molmil
Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.0
分子名称: Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
著者Huang, K.F, Liaw, S.S, Huang, W.L, Chia, C.Y, Lo, Y.C, Chen, Y.L, Wang, A.H.J.
登録日2010-10-20
公開日2011-02-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
J.Biol.Chem., 286, 2011
3PB8
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BU of 3pb8 by Molmil
Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase in complex with N-acetylhistamine
分子名称: Glutaminyl-peptide cyclotransferase-like protein, N-[2-(1H-IMIDAZOL-4-YL)ETHYL]ACETAMIDE, ZINC ION
著者Huang, K.F, Liaw, S.S, Huang, W.L, Chia, C.Y, Lo, Y.C, Chen, Y.L, Wang, A.H.J.
登録日2010-10-20
公開日2011-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
J.Biol.Chem., 286, 2011
3PB7
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BU of 3pb7 by Molmil
Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase in complex with PBD150
分子名称: 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
著者Huang, K.F, Liaw, S.S, Huang, W.L, Chia, C.Y, Lo, Y.C, Chen, Y.L, Wang, A.H.J.
登録日2010-10-20
公開日2011-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
J.Biol.Chem., 286, 2011
8XFV
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BU of 8xfv by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-(piperidin-4-yloxy)indolin-2-one
分子名称: 3-(1~{H}-benzimidazol-5-ylmethylidene)-4-piperidin-4-yloxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
著者Li, G.-B, Wang, X.-Y.
登録日2023-12-14
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (3.13 Å)
主引用文献X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGA
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BU of 8xga by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((tetrahydro-2H-pyran-4-yl)oxy)indolin-2-one
分子名称: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-(oxan-4-yloxy)-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
著者Li, G.-B, Wang, X.-Y.
登録日2023-12-15
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (3.537 Å)
主引用文献X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024

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件を2024-07-10に公開中

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