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PDB: 14 件
1XJV
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BU of 1xjv by Molmil
Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)
分子名称: Protection of telomeres 1, hT10 d(TTAGGGTTAG)
著者Lei, M, Podell, E.R, Cech, T.R.
登録日2004-09-25
公開日2004-12-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Nat.Struct.Mol.Biol., 11, 2004
3KJP
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BU of 3kjp by Molmil
Crystal Structure of hPOT1V2-GGTTAGGGTTAG
分子名称: 5'-D(*G*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3', Protection of telomeres protein 1
著者Nandakumar, J, Cech, T.R, Podell, E.R.
登録日2009-11-03
公開日2010-01-19
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KJO
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BU of 3kjo by Molmil
Crystal Structure of hPOT1V2-dTrUd(AGGGTTAG)
分子名称: DNA/RNA (5'-D(*T)-R(P*U)-D(P*AP*GP*GP*GP*TP*TP*AP*G)-3'), Protection of telomeres protein 1
著者Nandakumar, J, Cech, T.R, Podell, E.R.
登録日2009-11-03
公開日2010-01-19
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proc.Natl.Acad.Sci.USA, 107, 2010
5H65
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BU of 5h65 by Molmil
Crystal structure of human POT1 and TPP1
分子名称: Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION
著者Chen, C, Wu, J, Lei, M.
登録日2016-11-10
公開日2017-05-31
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
5UN7
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BU of 5un7 by Molmil
Structure of the human POT1-TPP1 telomeric complex
分子名称: Adrenocortical dysplasia protein homolog, POTASSIUM ION, Protection of telomeres protein 1, ...
著者Rice, C, Doukov, T, Skordalakes, E.
登録日2017-01-30
公開日2017-04-12
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and functional analysis of the human POT1-TPP1 telomeric complex.
Nat Commun, 8, 2017
8SH0
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BU of 8sh0 by Molmil
Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a telomeric DNA hairpin with a 3'-overhang
分子名称: ACETATE ION, DNA (5'-D(P*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), Protection of telomeres protein 1
著者Nandakumar, J, Tesmer, V.M.
登録日2023-04-13
公開日2023-08-30
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.
Science, 381, 2023
7S1U
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BU of 7s1u by Molmil
Structure of human POT1C
分子名称: Protection of telomeres protein 1, ZINC ION
著者Aramburu, T, Skordalakes, E.
登録日2021-09-02
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance.
Comput Struct Biotechnol J, 20, 2022
7S1O
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BU of 7s1o by Molmil
Structure of human POT1C
分子名称: Protection of telomeres protein 1, ZINC ION
著者Aramburu, T, Skordalakes, E.
登録日2021-09-02
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance.
Comput Struct Biotechnol J, 20, 2022
8SH1
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BU of 8sh1 by Molmil
Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a telomeric double-stranded DNA duplex with a 3'-overhang
分子名称: DNA (5'-D(*CP*GP*CP*GP*CP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*CP*GP*CP*GP*CP*G)-3'), Protection of telomeres protein 1
著者Nandakumar, J, Tesmer, V.M.
登録日2023-04-13
公開日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.
Science, 381, 2023
7S1T
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BU of 7s1t by Molmil
Structure of the human POT1-TPP1 complex
分子名称: Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION
著者Aramburu, T, Skordalakes, E.
登録日2021-09-02
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance.
Comput Struct Biotechnol J, 20, 2022
8SOJ
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BU of 8soj by Molmil
Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA
分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
著者Cai, S.W.
登録日2023-04-28
公開日2023-06-07
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献POT1 recruits and regulates CST-Pol alpha /Primase at human telomeres.
Biorxiv, 2023
7QXS
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BU of 7qxs by Molmil
Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains)
分子名称: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
著者Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
登録日2022-01-27
公開日2022-03-02
最終更新日2022-03-23
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
7QXB
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BU of 7qxb by Molmil
Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)
分子名称: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
著者Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
登録日2022-01-26
公開日2022-03-02
最終更新日2022-03-23
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
8SOK
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BU of 8sok by Molmil
Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA
分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
著者Cai, S.W.
登録日2023-04-28
公開日2023-06-07
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献POT1 recruits and regulates CST-Pol alpha /Primase at human telomeres.
Biorxiv, 2023

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件を2024-07-10に公開中

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