8SH0

Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a telomeric DNA hairpin with a 3'-overhang

Summary for 8SH0

• Entry DOI: 10.2210/pdb8sh0/pdb
• Descriptor: Protection of telomeres protein 1, DNA (5'-D(P*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), ACETATE ION, ... (4 entities in total)
• Functional Keywords: shelterin, telomere, dna junction, 5'-phosphorylated, pot-hole, chromosome end protection, pot1, dbd, pot1-dna complex, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 40244.00

Authors

Nandakumar, J.,Tesmer, V.M. (deposition date: 2023-04-13, release date: 2023-08-30)

• Primary citation: Tesmer, V.M.,Brenner, K.A.,Nandakumar, J.; Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.; Science, 381:771-778, 2023; PubMed: 37590346; DOI: 10.1126/science.adi2436

Experimental method

X-RAY DIFFRACTION (2.16 Å)