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PDB: 66 件
2RK3
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Structure of A104T DJ-1
分子名称: Protein DJ-1
著者Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A.
登録日2007-10-16
公開日2008-01-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
1P5F
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Crystal Structure of Human DJ-1
分子名称: RNA-binding protein regulatory subunit
著者Wilson, M.A, Collins, J.L, Hod, Y, Ringe, D, Petsko, G.A.
登録日2003-04-26
公開日2003-08-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The 1.1 A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease
Proc.Natl.Acad.Sci.USA, 100, 2003
5SYA
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Atomic resolution structure of D24N mutant human DJ-1
分子名称: 1,2-ETHANEDIOL, Protein deglycase DJ-1
著者Wilson, M.A, Lin, J.
登録日2016-08-10
公開日2016-12-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons.
Biochemistry, 56, 2017
5SY9
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Atomic resolution structure of E15Q mutant human DJ-1
分子名称: 1,2-ETHANEDIOL, Protein deglycase DJ-1
著者Wilson, M.A, Lin, J.
登録日2016-08-10
公開日2016-12-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons.
Biochemistry, 56, 2017
3EZG
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Crystal structure of E18Q DJ-1 with oxidized C106
分子名称: Protein DJ-1
著者Lakshminarasimhan, M, Wilson, M.A.
登録日2008-10-22
公開日2008-12-30
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.
J.Biol.Chem., 284, 2009
3CZ9
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Crystal Structure of E18L DJ-1
分子名称: O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, Protein DJ-1
著者Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hasim, S, Pozharski, E, Wilson, M.A.
登録日2008-04-28
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
5SY6
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Atomic resolution structure of human DJ-1, DTT bound
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Protein deglycase DJ-1
著者Wilson, M.A, Lin, J.
登録日2016-08-10
公開日2016-12-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons.
Biochemistry, 56, 2017
2RK6
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Structure of E163K DJ-1
分子名称: Protein DJ-1
著者Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A.
登録日2007-10-16
公開日2008-01-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
2RK4
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Structure of M26I DJ-1
分子名称: Protein DJ-1
著者Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A.
登録日2007-10-16
公開日2008-01-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
4P36
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Crystal structure of DJ-1 With Zn(II) bound (crystal 2)
分子名称: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Protein DJ-1, ZINC ION
著者Tashiro, S, Wu, C.-X, Hoang, Q.Q, Caaveiro, J.M.M, Tsumoto, K.
登録日2014-03-05
公開日2014-04-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.182 Å)
主引用文献Thermodynamic and Structural Characterization of the Specific Binding of Zn(II) to Human Protein DJ-1.
Biochemistry, 53, 2014
3F71
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Crystal structure of E18D DJ-1 with oxidized C106
分子名称: Protein DJ-1
著者Lakshminarasimhan, M, Wilson, M.A.
登録日2008-11-07
公開日2008-12-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1.
J.Biol.Chem., 284, 2009
2OR3
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Pre-oxidation Complex of Human DJ-1
分子名称: Protein DJ-1, SULFATE ION
著者Witt, A.C, Lakshminarasimhan, M, Wilson, M.A.
登録日2007-02-01
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
3CZA
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Crystal Structure of E18D DJ-1
分子名称: MALONIC ACID, Protein DJ-1
著者Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hashim, S, Pozharski, E, Wilson, M.A.
登録日2008-04-28
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
1SOA
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BU of 1soa by Molmil
Human DJ-1 with sulfinic acid
分子名称: RNA-binding protein regulatory subunit; oncogene DJ1
著者Canet-Aviles, R, Wilson, M.A, Miller, D.W, Ahmad, R, McLendon, C, Bandyopadhyay, S, Baptista, M.J, Ringe, D, Petsko, G.A, Cookson, M.R.
登録日2004-03-13
公開日2004-06-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.
Proc.Natl.Acad.Sci.USA, 101, 2004
7PA2
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PARK7 with inhibitor 8RK64
分子名称: (3~{S})-~{N}-[5-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethanoyl]-6,7-dihydro-4~{H}-[1,3]thiazolo[5,4-c]pyridin-2-yl]-1-(iminomethyl)pyrrolidine-3-carboxamide, Parkinson disease protein 7
著者Kim, R.Q, Jia, Y, Sapmaz, A, Geurink, P.P.
登録日2021-07-28
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.
J.Med.Chem., 65, 2022
4ZGG
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BU of 4zgg by Molmil
Crystal structure of a DJ-1 (PARK7) from Homo sapiens at 1.23 A resolution
分子名称: 1,2-ETHANEDIOL, Protein deglycase DJ-1
著者Joint Center for Structural Genomics (JCSG), Partnership for Nuclear Receptor Signaling Code Biology (NHRS), Partnership for T-Cell Biology (TCELL)
登録日2015-04-22
公開日2015-05-20
最終更新日2023-02-01
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Crystal structure of a DJ-1 (PARK7) from Homo sapiens at 1.23 A resolution
To be published
6AF7
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DJ-1 C106S unbound
分子名称: CHLORIDE ION, PENTAETHYLENE GLYCOL, Protein/nucleic acid deglycase DJ-1
著者Caaveiro, J.M.M, Tashiro, S, Tsumoto, K.
登録日2018-08-08
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.
ACS Chem. Biol., 13, 2018
6E5Z
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Crystal structure of human DJ-1 with a natural modification on Cys-106
分子名称: CHLORIDE ION, Protein/nucleic acid deglycase DJ-1
著者Shumilin, I.A, Shumilina, S.V, Minor, W.
登録日2018-07-23
公開日2018-08-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.
Biochem. Biophys. Res. Commun., 504, 2018
3CY6
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Crystal Structure of E18Q DJ-1
分子名称: Protein DJ-1
著者Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hasim, S, Pozharski, E, Wilson, M.A.
登録日2008-04-25
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
4P2G
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Crystal structure of DJ-1 in sulfinic acid form (aged crystal)
分子名称: 1,2-ETHANEDIOL, PENTAETHYLENE GLYCOL, Protein DJ-1
著者Tashiro, S, Wu, C.-X, Hoang, Q.Q, Caaveiro, J.M.M, Tsumoto, K.
登録日2014-03-04
公開日2014-04-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Thermodynamic and Structural Characterization of the Specific Binding of Zn(II) to Human Protein DJ-1.
Biochemistry, 53, 2014
4BTE
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DJ-1 Cu(I) complex
分子名称: COPPER (I) ION, PROTEIN DJ-1
著者Puno, M.R.A, Odell, M, Moody, P.C.E.
登録日2013-06-14
公開日2013-11-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure of Cu(I)-Bound Dj-1 Reveals a Biscysteinate Metal Binding Site at the Homodimer Interface: Insights Into Mutational Inactivation of Dj-1 in Parkinsonism.
J.Am.Chem.Soc., 135, 2013
6AF9
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DJ-1 with isatin bound (high concentration)
分子名称: CHLORIDE ION, ISATIN, Protein/nucleic acid deglycase DJ-1
著者Caaveiro, J.M.M, Tashiro, S, Tsumoto, K.
登録日2018-08-08
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.
ACS Chem. Biol., 13, 2018
7PA3
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PARK7 with covalent inhibitor JYQ-88
分子名称: (3~{S})-~{N}-[5-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethanoyl]-6,7-dihydro-4~{H}-[1,3]thiazolo[5,4-c]pyridin-2-yl]-1-(iminomethyl)pyrrolidine-3-carboxamide, Parkinson disease protein 7
著者Kim, R.Q, Jia, Y, Sapmaz, A, Geurink, P.P.
登録日2021-07-28
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.
J.Med.Chem., 65, 2022
4S0Z
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Crystal structure of M26V human DJ-1
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Protein DJ-1
著者Milkovic, N.M, Wilson, M.A.
登録日2015-01-07
公開日2015-08-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.
Protein Sci., 24, 2015
6AFC
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DJ-1 with compound 4
分子名称: 5-fluoranyl-1~{H}-indole-2,3-dione, CHLORIDE ION, Protein/nucleic acid deglycase DJ-1
著者Caaveiro, J.M.M, Tashiro, S, Tsumoto, K.
登録日2018-08-08
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.
ACS Chem. Biol., 13, 2018

 

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