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PDB: 15 件
7BU5
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BU of 7bu5 by Molmil
Crystal Structure of Human SLX4 and MUS81
分子名称: GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ...
著者Wan, B, Wu, J, Lei, M.
登録日2020-04-04
公開日2021-04-07
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain
To be published
9F9L
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Crystal structure of MUS81-EME1 bound by compound 16.
分子名称: 2-[2-[4-(cyanomethyl)phenyl]phenyl]-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors
Acs Med.Chem.Lett., 2024
9F98
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Crystal structure of MUS81-EME1, apo form.
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81
著者Collie, G.W.
登録日2024-05-07
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors
Acs Med.Chem.Lett., 2024
9F9M
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Crystal structure of MUS81-EME1 bound by compound 21.
分子名称: 5-oxidanyl-4-oxidanylidene-1-(4-piperazin-1-ylphenyl)pyridine-3-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-08
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.469 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors
Acs Med.Chem.Lett., 2024
9F9K
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BU of 9f9k by Molmil
Crystal structure of MUS81-EME1 bound by compound 15.
分子名称: 5-oxidanyl-6-oxidanylidene-2-(4-phenylphenyl)-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.728 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors
Acs Med.Chem.Lett., 2024
4P0P
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BU of 4p0p by Molmil
Crystal structure of Human Mus81-Eme1 in complex with 5'-flap DNA, and Mg2+
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, DNA GAATGTGTGTCTCAATC, ...
著者Gwon, G.H, Baek, K, Cho, Y.
登録日2014-02-22
公開日2014-05-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Embo J., 33, 2014
9F99
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Crystal structure of MUS81-EME1 bound by compound 10.
分子名称: 2-(4-chlorophenyl)-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors
Acs Med.Chem.Lett., 2024
4P0Q
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BU of 4p0q by Molmil
Crystal structure of Human Mus81-Eme1 in complex with 5'-flap DNA
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, DNA GAATGTGTGTCTCAATC, ...
著者Gwon, G.H, Baek, K, Cho, Y.
登録日2014-02-22
公開日2014-05-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.851 Å)
主引用文献Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Embo J., 33, 2014
9F9A
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BU of 9f9a by Molmil
Crystal structure of MUS81-EME1 bound by compound 12.
分子名称: 2-naphthalen-2-yl-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.911 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors
Acs Med.Chem.Lett., 2024
7F6L
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Crystal structure of human MUS81-EME2 complex
分子名称: Crossover junction endonuclease MUS81, Probable crossover junction endonuclease EME2
著者Hua, Z.K, Zhang, D.P, Yuan, C, Lin, Z.H.
登録日2021-06-25
公開日2022-03-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the human MUS81-EME2 complex.
Structure, 30, 2022
2ZIX
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BU of 2zix by Molmil
Crystal structure of the Mus81-Eme1 complex
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81
著者Chang, J.H, Kim, J.J, Choi, J.M, Lee, J.H, Cho, Y.
登録日2008-02-25
公開日2008-04-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal structure of the Mus81-Eme1 complex
Genes Dev., 22, 2008
4P0S
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BU of 4p0s by Molmil
human Mus81-Eme1-3'flap DNA complex
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, DNA GAATGTGTGTCT, ...
著者Gwon, G.H, Baek, K, Cho, Y.
登録日2014-02-22
公開日2014-05-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Embo J., 33, 2014
4P0R
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BU of 4p0r by Molmil
human Mus81-Eme1-3'flap DNA complex
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, DNA ACGTGCTTACACACAGAGGTTAGGGTGAACTT, ...
著者Gwon, G.H, Baek, K, Cho, Y.
登録日2014-02-22
公開日2014-05-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (6.501 Å)
主引用文献Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Embo J., 33, 2014
6VWB
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BU of 6vwb by Molmil
Solution structure of the N-terminal helix-hairpin-helix domain of human MUS81
分子名称: Crossover junction endonuclease MUS81
著者Payliss, B, Houliston, S, Lemak, A, Arrowsmith, C.H, Wyatt, H.D.M.
登録日2020-02-19
公開日2021-02-24
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease
Cell Rep, 41, 2022
2MC3
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NMR solution structure of the winged-helix domain from MUS81 structure-specific endonuclease
分子名称: MUS81 endonuclease homolog (Yeast), isoform CRA_b
著者Harris, R, Fadden, A, Mcdonald, N.Q.
登録日2013-08-14
公開日2013-09-18
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.
Nucleic Acids Res., 41, 2013

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件を2024-07-24に公開中

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