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PDB: 18 件
4D0Q
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Hyaluronan Binding Module of the Streptococcal Pneumoniae Hyaluronate Lyase
分子名称: 1,2-ETHANEDIOL, HYALURONATE LYASE
著者Suits, M.D.L, Pluvinage, B, Law, A, Liu, Y, Palma, A.S, Chai, W, Feizi, T, Boraston, A.B.
登録日2014-04-29
公開日2014-08-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Conformational Analysis of the Streptococcus Pneumoniae Hyaluronate Lyase and Characterization of its Hyaluronan-Specific Carbohydrate-Binding Module.
J.Biol.Chem., 289, 2014
1N7O
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Streptococcus pneumoniae Hyaluronate Lyase F343V Mutant
分子名称: hyaluronidase
著者Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J.
登録日2002-11-16
公開日2002-12-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The function of hydrophobic residues in the catalytic cleft of Streptococcus pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
1LXK
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Streptococcus pneumoniae Hyaluronate Lyase in Complex with Tetrasaccharide Hyaluronan Substrate
分子名称: Hyaluronate Lyase, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Jedrzejas, M.J, Mello, L.V, De Groot, B.L, Li, S.
登録日2002-06-05
公開日2002-08-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Structures of complexes with the substrate.
J.Biol.Chem., 277, 2002
1N7P
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Streptococcus pneumoniae Hyaluronate Lyase W292A/F343V Double Mutant
分子名称: HYALURONIDASE
著者Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J.
登録日2002-11-16
公開日2002-12-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The function of hydrophobic residues in the catalytic cleft of Streptococcus pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
1N7N
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Streptococcus pneumoniae Hyaluronate Lyase W292A Mutant
分子名称: HYALURONIDASE
著者Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J.
登録日2002-11-16
公開日2002-12-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The function of hydrophobic residues in the catalytic cleft of Streptococcus pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
1EGU
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE AT 1.56 A RESOLUTION
分子名称: HYALURONATE LYASE, SULFATE ION
著者Li, S, Kelly, S.J, Lamani, E, Ferraroni, M, Jedrzejas, M.J.
登録日2000-02-16
公開日2001-02-16
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase.
EMBO J., 19, 2000
1OJN
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SPECIFICITY AND MECHANISM OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE: COMPLEX OF THE TYR408PHE MUTANT WITH 6-SULPHATED CHONDROITIN DISACCHARIDE
分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-6-O-sulfo-beta-D-galactopyranose, HYALURONATE LYASE, SULFATE ION
著者Rigden, D.J, Jedrzejas, M.J.
登録日2003-07-11
公開日2003-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of Streptococcus Pneumoniae Hyaluronate Lyase in Complex with Chondroitin and Chondroitin Sulfate Disaccharides: Insights Into Specificity and Mechanism of Action
J.Biol.Chem., 278, 2003
1W3Y
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Crystal structure of S. pneumoniae hyaluronate lyase in complex with palmitoyl-vitamin C
分子名称: (2E,4R,5S)-2,3,4,5-TETRAHYDROXY-6-(PALMITOYLOXY)HEX-2-ENOIC ACID, HYALURONATE LYASE, SULFATE ION, ...
著者Rigden, D.J, Jedrzejas, M.J.
登録日2004-07-21
公開日2004-08-26
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-Ray Structure and Molecular Modeling of Enzyme-Inhibitor Complexes
J.Biol.Chem., 279, 2004
1C82
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MECHANISM OF HYALURONAN BINDING AND DEGRADATION: STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE IN COMPLEX WITH HYALURONIC ACID DISACCHARIDE AT 1.7 A RESOLUTION
分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, HYALURONATE LYASE, ...
著者Ponnuraj, K, Jedrzejas, M.J.
登録日2000-04-05
公開日2001-04-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Mechanism of hyaluronan binding and degradation: structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 A resolution.
J.Mol.Biol., 299, 2000
1OJO
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SPECIFICITY AND MECHANISM OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE: COMPLEX OF THE TYR408PHE MUTANT WITH 4-SULPHATED CHONDROITIN DISACCHARIDE
分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose, HYALURONATE LYASE, SULFATE ION
著者Rigden, D.J, Jedrzejas, M.J.
登録日2003-07-11
公開日2003-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of Streptococcus Pneumoniae Hyaluronate Lyase in Complex with Chondroitin and Chondroitin Sulfate Disaccharides: Insights Into Specificity and Mechanism of Action
J.Biol.Chem., 278, 2003
1OJM
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SPECIFICITY AND MECHANISM OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE: COMPLEX WITH UNSULPHATED CHONDROITIN DISACCHARIDE
分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, HYALURONATE LYASE, SULFATE ION
著者Rigden, D.J, Jedrzejas, M.J.
登録日2003-07-11
公開日2003-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structures of Streptococcus Pneumoniae Hyaluronate Lyase in Complex with Chondroitin and Chondroitin Sulfate Disaccharides: Insights Into Specificity and Mechanism of Action
J.Biol.Chem., 278, 2003
1OJP
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SPECIFICITY AND MECHANISM OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE: COMPLEX WITH 6-SULPHATED CHONDROITIN DISACCHARIDE
分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-6-O-sulfo-beta-D-galactopyranose, HYALURONATE LYASE, SULFATE ION
著者Rigden, D.J, Jedrzejas, M.J.
登録日2003-07-11
公開日2003-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of Streptococcus Pneumoniae Hyaluronate Lyase in Complex with Chondroitin and Chondroitin Sulfate Disaccharides: Insights Into Specificity and Mechanism of Action
J.Biol.Chem., 278, 2003
1F9G
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE COCRYSTALLIZED WITH ASCORBIC ACID
分子名称: ASCORBIC ACID, HYALURONATE LYASE
著者Li, S, Jedrzejas, M.J.
登録日2000-07-10
公開日2001-05-16
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Vitamin C inhibits the enzymatic activity of Streptococcus pneumoniae hyaluronate lyase.
J.Biol.Chem., 276, 2001
2BRP
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Crystal structure of S. pneumoniae hyaluronate lyase in complex with W249b
分子名称: D-xylose, HYALURONATE LYASE, SULFAMIC ACID 1-DECYL-2-(4-SULFAMOYLOXYPHENYL)-1H-INDOL-6-YL ESTER, ...
著者Rigden, D.J, Jedrzejas, M.J.
登録日2005-05-10
公開日2006-04-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
Glycobiology, 16, 2006
1LOH
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Streptococcus pneumoniae Hyaluronate Lyase in Complex with Hexasaccharide Hyaluronan Substrate
分子名称: Hyaluronate Lyase, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Jedrzejas, M.J, Mello, L.V, De Groot, B.L, Li, S.
登録日2002-05-06
公開日2002-08-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Structures of complexes with the substrate.
J.Biol.Chem., 277, 2002
1N7R
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Streptococcus pneumoniae Hyaluronate Lyase W291A/W292A/F343V Mutant complex with hexasaccharide hyaluronan
分子名称: HYALURONIDASE, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J.
登録日2002-11-16
公開日2002-12-31
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The function of hydrophobic residues in the catalytic cleft of Streptococcus pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms
J.Biol.Chem., 278, 2003
2BRW
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Crystal structure of Streptococcus Pneumoniae Hyaluronate Lyase from 30percent PEGMME.
分子名称: HYALURONATE LYASE, SULFATE ION
著者Rigden, D.J, Littlejohn, J.E, Jedrzejas, M.J.
登録日2005-05-11
公開日2006-04-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Alternate Structural Conformations of Streptococcus Pneumoniae Hyaluronan Lyase: Insights Into Enzyme Flexibility and Underlying Molecular Mechanism of Action.
J.Mol.Biol., 358, 2006
2BRV
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Crystal structure of Streptococcus Pneumoniae Hyaluronate Lyase from 70percent saturated malonate.
分子名称: HYALURONATE LYASE, MALONIC ACID
著者Rigden, D.J, Jedrzejas, M.J.
登録日2005-05-11
公開日2006-04-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Alternate Structural Conformations of Streptococcus Pneumoniae Hyaluronan Lyase: Insights Into Enzyme Flexibility and Underlying Molecular Mechanism of Action.
J.Mol.Biol., 358, 2006

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