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PDB: 1180 件
7TUD
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Crystal structure of HLA-B*44:05 (T73C) with 6mer EEFGRC and dipeptide GL
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, EEFGRC peptide, ...
著者Jiang, J, Natarajan, K, Kim, E, Boyd, L.F, Margulies, D.H.
登録日2022-02-02
公開日2022-09-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation.
Nat Commun, 13, 2022
7X00
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Crystal structure of peptide VSFIEFVGW in complex with HLA-B5801
分子名称: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
著者Huan, X, Ren, E.C.
登録日2022-02-20
公開日2023-05-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01.
Sci Rep, 13, 2023
4RMQ
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Crystal structure of the D59N Beta-2 Microglobulin mutant
分子名称: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER
著者de Rosa, M, Bolognesi, M, Ricagno, S.
登録日2014-10-22
公開日2015-11-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.461 Å)
主引用文献Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
Plos One, 10, 2015
5C0F
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HLA-A02 carrying RQWGPDPAAV
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETIC ACID, ...
著者Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K.
登録日2015-06-12
公開日2016-05-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.463 Å)
主引用文献Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J.Clin.Invest., 126, 2016
4RMV
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Crystal structure of the D76H Beta-2 Microglobulin mutant
分子名称: ACETATE ION, Beta-2-microglobulin, TRIETHYLENE GLYCOL
著者de Rosa, M, Bolognesi, M, Ricagno, S.
登録日2014-10-22
公開日2015-11-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.463 Å)
主引用文献Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nat Commun, 9, 2018
4U6Y
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Crystal Structure of HLA-A*0201 in complex with FLNDK, a 15 mer self-peptide
分子名称: Beta-2-microglobulin, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Gras, S, Chabrol, E, Rossjohn, J.
登録日2014-07-30
公開日2014-12-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.467 Å)
主引用文献Naturally Processed Non-canonical HLA-A*02:01 Presented Peptides.
J.Biol.Chem., 290, 2015
1OGT
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BU of 1ogt by Molmil
CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE VASOACTIVE INTESTINAL PEPTIDE TYPE 1 RECEPTOR (VIPR) PEPTIDE (RESIDUES 400-408)
分子名称: BETA-2-MICROGLOBULIN, GLYCEROL, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ...
著者Hulsmeyer, M, Fiorillo, M.T, Bettosini, F, Sorrentino, R, Saenger, W, Ziegler, A, Uchanska-Ziegler, B.
登録日2003-05-13
公開日2004-01-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Dual, HLA-B27 subtype-dependent conformation of a self-peptide.
J. Exp. Med., 199, 2004
1XH3
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BU of 1xh3 by Molmil
Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Probst-Kepper, M, Hecht, H.J, Herrmann, H, Janke, V, Ocklenburg, F, Klempnauer, J, van den Eynde, B.J, Weiss, S.
登録日2004-09-17
公開日2004-11-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Conformational restraints and flexibility of 14-meric peptides in complex with HLA-B*3501.
J.Immunol., 173, 2004
6P2F
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Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ...
著者Li, L, Batliwala, M, Bouvier, M.
登録日2019-05-21
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.482 Å)
主引用文献ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
J.Biol.Chem., 294, 2019
8E8I
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BU of 8e8i by Molmil
Structures of HLA-B8E76C loaded with long peptides reveal novel features at the N-terminus of the groove
分子名称: Beta-2-microglobulin, MHC class I antigen, PHE-VAL-LYS-LYS-LYS-TYR-CYS-LEU
著者Li, L, Bouvier, M.
登録日2022-08-25
公開日2023-07-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing.
Nat Commun, 14, 2023
5CFH
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human beta-2 microglobulin double mutant W60G-Y63W
分子名称: Beta-2-microglobulin
著者Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S.
登録日2015-07-08
公開日2016-05-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Sci Rep, 6, 2016
5C0E
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HLA-A02 carrying YLGGPDFPTI
分子名称: 1,2-ETHANEDIOL, BROMIDE ION, Beta-2-microglobulin, ...
著者Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K.
登録日2015-06-12
公開日2016-05-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.491 Å)
主引用文献Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J.Clin.Invest., 126, 2016
7M8T
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Crystal Structure of HLA-A*11:01 in complex with NSASFSTFK, an 9-mer epitope from SARS-CoV-2 spike (S370-378)
分子名称: Beta-2-microglobulin, CALCIUM ION, CHLORIDE ION, ...
著者Gras, S, Nguyen, A.T, Szeto, C.
登録日2021-03-30
公開日2021-06-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献SARS-CoV-2 Spike-Derived Peptides Presented by HLA Molecules
Biophysica, 1, 2021
6O4Z
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Structure of HLA-A2:01 with peptide MM92
分子名称: Beta-2-microglobulin, GLYCEROL, MHC class I antigen, ...
著者Ying, G, Bitra, A, Zajonc, D.M.
登録日2019-03-01
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Anin silico-in vitroPipeline Identifying an HLA-A*02:01+KRAS G12V+Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients.
Front Immunol, 10, 2019
6WZY
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BU of 6wzy by Molmil
Structure of DbNA(10) peptides bound to H-2Db MHC-I
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
著者Farenc, C, Rossjohn, J.
登録日2020-05-14
公開日2020-09-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Overlapping Peptides Elicit Distinct CD8 + T Cell Responses following Influenza A Virus Infection.
J Immunol., 205, 2020
7YG3
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BU of 7yg3 by Molmil
Crystal structure of HLA-B*13:01
分子名称: ARG-GLN-ASP-ILE-LEU-ASP-LEU-TRP-ILE, Beta-2-microglobulin, MHC class I antigen
著者Wang, H.S, Ouyang, S.Y.
登録日2022-07-11
公開日2023-07-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity.
J.Biomed.Sci., 29, 2022
2FYY
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BU of 2fyy by Molmil
The role of T cell receptor alpha genes in directing human MHC restriction
分子名称: 11-mer peptide from Epstein-Barr nuclear antigen 1, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Miles, J.J, Borg, N.A.
登録日2006-02-08
公開日2006-12-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
J Immunol., 177, 2006
5DDH
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BU of 5ddh by Molmil
Structure of HLA-A2:01 with the 12-mer peptide F12K
分子名称: 12-mer peptide F12K, Beta-2-microglobulin, GLYCEROL, ...
著者Remesh, S.G, Zajonc, D.
登録日2015-08-24
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove.
Elife, 5, 2016
3VFN
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BU of 3vfn by Molmil
crystal structure of HLA B*3508LPEP151A, HLA mutant Ala151
分子名称: Beta-2-microglobulin, LPEP peptide from EBV, LPEPLPQGQLTAY, ...
著者Liu, Y, Rossjohn, J, Gras, S.
登録日2012-01-10
公開日2012-03-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule.
J.Biol.Chem., 287, 2012
5IEH
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BU of 5ieh by Molmil
Structure of HLA-B*40:02 in complex with the phosphorylated endogenous peptide REF(p)SKEPEL
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Alpizar, A, Marcilla, M, Santiago, C.
登録日2016-02-25
公開日2016-12-07
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of HLA-B*40:02 in complex with the phosphorilated endogenous peptide REFpSKEPEL
To Be Published
7WKJ
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BU of 7wkj by Molmil
A COVID-19 T-cell response detection method based on a newly identified human CD8+ T cell epitope from SARS-CoV-2-Hubei Province, 2021.
分子名称: Beta-2-microglobulin, LYS-THR-PHE-PRO-PRO-THR-GLU-PRO-LYS, MHC class I antigen
著者Zhang, J, Lu, D, Li, M, Liu, M.S, Yao, S.J, Zhan, J.B, Liu, J, Gao, G.F.
登録日2022-01-10
公開日2022-03-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A COVID-19 T-Cell Response Detection Method Based on a Newly Identified Human CD8 + T Cell Epitope from SARS-CoV-2 - Hubei Province, China, 2021.
China CDC Wkly, 4, 2022
1ZHL
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BU of 1zhl by Molmil
Crystal structure of HLA-B*3508 presenting 13-mer EBV antigen LPEPLPQGQLTAY
分子名称: Beta-2-microglobulin, EBV-peptide LPEPLPQGQLTAY, HLA class I histocompatibility antigen, ...
著者Tynan, F.E, Borg, N.A, Miles, J.J, Beddoe, T, El-Hassen, D, Silins, S.L, van Zuylen, W.J, Purcell, A.W, Kjer-Nielsen, L, McCluskey, J, Burrows, S.R, Rossjohn, J.
登録日2005-04-26
公開日2005-05-17
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance
J.Biol.Chem., 280, 2005
2HJL
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Crystal Structure of HLA-B5703 and HIV-1 peptide
分子名称: Beta-2-microglobulin, Gag protein, HLA class I histocompatibility antigen B-57
著者Gillespie, G.M.A, Stewart-Jones, G, Rengasamy, J, Beattie, T, Bwayo, J.J, Plummer, F.A.
登録日2006-06-30
公開日2006-10-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection.
J.Immunol., 177, 2006
6Q3K
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Engineered Human HLA_A2 MHC Class I molecule in complex with NV9 peptide
分子名称: ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, COBALT (II) ION, ...
著者Meijers, R, Anjanappa, R, Springer, S, Garcia-Alai, M.
登録日2018-12-04
公開日2019-07-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Engineered Human HLA_A2MHC Class I molecule in complex with NV9 peptide
Sci Immunol, 2019
6AT5
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Crystal structure of HLA-B*07:02 in complex with an NY-ESO-1 peptide
分子名称: Beta-2-microglobulin, Cancer/testis antigen 1 peptide, HLA class I histocompatibility antigen, ...
著者Gully, B.S, Rossjohn, J.
登録日2017-08-27
公開日2018-02-28
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.
Nat Commun, 9, 2018

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