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PDB: 181 件
8ZDX
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Crystal structure of MjHKU4r-CoV-1 RBD bound to hDPP4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Yang, M, Li, Z, Xu, Y, Zhang, S.
登録日2024-05-03
公開日2024-10-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of MjHKU4r-CoV-1 RBD bound to hDPP4
To Be Published
2DCM
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The Crystal Structure of S603A Mutated Prolyl Tripeptidyl Aminopeptidase Complexed with Substrate
分子名称: GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE, dipeptidyl aminopeptidase IV, putative
著者Nakajima, Y, Ito, K, Xu, Y, Yamada, N, Onohara, Y, Yoshimoto, T.
登録日2006-01-09
公開日2006-09-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis
J.Mol.Biol., 362, 2006
1U8E
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 MUTANT Y547F
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Bjelke, J.R, Christensen, J, Branner, S, Wagtmann, N, Olsen, C, Kanstrup, A.B, Rasmussen, H.B.
登録日2004-08-05
公開日2004-08-17
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
J.Biol.Chem., 279, 2004
4DTC
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BU of 4dtc by Molmil
Crystal Structure of DPP-IV with Compound C5
分子名称: Dipeptidyl peptidase 4, N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3'-(trifluoromethyl)biphenyl-4-carboxamide
著者Xiong, B, Zhu, L.R, Chen, D.Q, Zhao, Y.L, Jiang, F, Shen, J.K.
登録日2012-02-21
公開日2013-02-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of DPP-IV with Compound C5
To be Published
3NOX
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BU of 3nox by Molmil
Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl-peptidase 4 (CD26, ...
著者Klei, H.E.
登録日2010-06-25
公開日2010-08-11
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.338 Å)
主引用文献Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors.
J.Med.Chem., 53, 2010
6L8Q
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BU of 6l8q by Molmil
Complex structure of bat CD26 and MERS-RBD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ...
著者Yuan, Y.
登録日2019-11-07
公開日2019-12-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species.
J.Virol., 94, 2020
4QZV
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Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ...
著者Gao, F.G, Wang, Q.H, Qi, J.X, Lu, G.W.
登録日2014-07-29
公開日2014-10-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26.
Cell Host Microbe, 16, 2014
4WJL
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Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive dipeptidyl peptidase 10, ...
著者Bezerra, G.A, Dobrovetsky, E, Seitova, A, Fedosyuk, S, Dhe-Paganon, S, Gruber, K.
登録日2014-09-30
公開日2015-03-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
Sci Rep, 5, 2015
8WKU
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Complex structure of MjHKU4r-CoV-1 spike RBD bound to human CD26
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 soluble form, MjHKU4r-CoV-1 spike RBD, ...
著者Zhao, Z.N, Chai, Y, Gao, F.
登録日2023-09-28
公開日2024-06-26
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Molecular basis for receptor recognition and broad host tropism for merbecovirus MjHKU4r-CoV-1.
Embo Rep., 25, 2024
5OLJ
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Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4
分子名称: Dipeptidyl peptidase IV, GLYCEROL
著者Fulop, V.
登録日2017-07-27
公開日2017-09-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling.
Eur J Med Chem, 139, 2017
7ZXS
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BU of 7zxs by Molmil
Crystal structure of DPP9 in complex with a 4-oxo-b-lactam based inhibitor, A295
分子名称: 1,2-ETHANEDIOL, 2-ethyl-2-methanoyl-~{N}-[3-[[4-(quinolin-8-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide, DI(HYDROXYETHYL)ETHER, ...
著者Ross, B, Huber, R.
登録日2022-05-22
公開日2022-09-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Angew.Chem.Int.Ed.Engl., 61, 2022
8PBA
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BU of 8pba by Molmil
Cryo-EM structure of Caenorhabditis elegans DPF-3 (apo)
分子名称: Dipeptidyl Peptidase Four (IV) family
著者Gudipati, R.K, Cavadini, S, Kempf, G, Grosshans, H.
登録日2023-06-08
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (2.64 Å)
主引用文献Cryo-EM structure of Caenorhabditis elegans DPF-3 (apo)
To Be Published
1J2E
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BU of 1j2e by Molmil
Crystal structure of Human Dipeptidyl peptidase IV
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV
著者Hiramatsu, H, Kyono, K, Higashiyama, Y, Fukushima, C, Shima, H, Sugiyama, S, Inaka, K, Yamamoto, A, Shimizu, R.
登録日2002-12-30
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold.
Biochem.Biophys.Res.Commun., 302, 2003
6HP8
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BU of 6hp8 by Molmil
Crystal structure of DPP8 in complex with Val-BoroPro
分子名称: Dipeptidyl peptidase 8, GLYCEROL, SODIUM ION, ...
著者Ross, B.H, Huber, R.
登録日2018-09-19
公開日2019-07-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Improvement of Protein Crystal Diffraction Using Post-Crystallization Methods: Infrared Laser Radiation Controls Crystal Order
Thesis, 2019
5VTA
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BU of 5vta by Molmil
Co-Crystal Structure of DPPIV with a Chemibody Inhibitor
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]piperazin-1-yl}-N-(22-oxo-3,6,9,12,15,18-hexaoxa-21-azatricosan-1-yl)acetamide, ...
著者Wang, Z, Johnstone, S, Cheng, A.
登録日2017-05-16
公開日2018-05-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-guided Discovery of Dual-recognition Chemibodies.
Sci Rep, 8, 2018
6QZV
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DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2
分子名称: Dipeptidyl peptidase 9, MET-PRO
著者Ross, B, Geiss-Friedlander, R, Huber, R.
登録日2019-03-12
公開日2020-09-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Biorxiv, 2020
3WQH
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BU of 3wqh by Molmil
Crystal Structure of human DPP-IV in complex with Anagliptin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
著者Watanabe, Y.S, Okada, S, Motoyama, T, Takahashi, R, Adachi, H, Oka, M.
登録日2014-01-27
公開日2015-07-15
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions.
J Enzyme Inhib Med Chem, 30, 2015
7OR4
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BU of 7or4 by Molmil
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B142
分子名称: Dipeptidyl peptidase 8, methyl 3-[4-[(4-bromophenyl)methyl]piperazin-1-yl]carbonyl-5-[(2-ethyl-2-methanoyl-butanoyl)amino]benzoate, trimethylamine oxide
著者Ross, B, Huber, R.
登録日2021-06-04
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Angew.Chem.Int.Ed.Engl., 61, 2022
7OZ7
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Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, L84
分子名称: Dipeptidyl peptidase 8, trimethylamine oxide, ~{N}-[3-[[4-[(4-bromophenyl)methyl]piperazin-1-yl]methyl]phenyl]-2-ethyl-2-methanoyl-butanamide
著者Ross, B, Huber, R.
登録日2021-06-26
公開日2021-07-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Angew.Chem.Int.Ed.Engl., 61, 2022
3KWF
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human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
分子名称: (4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-(fluoromethyl)pyrrolidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4
著者Hennig, M, Stihle, M, Thoma, R.
登録日2009-12-01
公開日2010-01-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg.Med.Chem.Lett., 20, 2010
6QZW
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DPP8 bound to a dipeptide (MP) from the N-terminus of BRCA2
分子名称: Dipeptidyl peptidase 8, MET-PRO, SODIUM ION
著者Ross, B, Geiss-Friedlander, R, Huber, R.
登録日2019-03-12
公開日2020-09-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Biorxiv, 2020
4A5S
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CRYSTAL STRUCTURE OF HUMAN DPP4 IN COMPLEX WITH A NOVAL HETEROCYCLIC DPP4 INHIBITOR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[(3S)-3-AMINOPIPERIDIN-1-YL]-5-BENZYL-4-OXO-3-(QUINOLIN-4-YLMETHYL)-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBONITRILE, DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM, ...
著者Ostermann, N, Kroemer, M, Zink, F, Gerhartz, B, Sutton, J.M, Clark, D.E, Dunsdon, S.J, Fenton, G, Fillmore, A, Harris, N.V, Higgs, C, Hurley, C.A, Krintel, S.L, MacKenzie, R.E, Duttaroy, A, Gangl, E, Maniara, W, Sedrani, R, Namoto, K, Sirockin, F, Trappe, J, Hassiepen, U, Baeschlin, D.K.
登録日2011-10-28
公開日2012-02-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Novel Heterocyclic Dpp-4 Inhibitors for the Treatment of Type 2 Diabetes.
Bioorg.Med.Chem.Lett., 22, 2012
7JN7
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Human DPP9-CARD8 complex
分子名称: Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9, [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid
著者Sharif, H, Hollingsworth, L.R.
登録日2020-08-04
公開日2021-05-19
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Immunity, 54, 2021
7JKQ
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Human DPP9-CARD8 complex
分子名称: Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9
著者Sharif, H, Hollingsworth, L.R.
登録日2020-07-28
公開日2021-05-26
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Immunity, 54, 2021
2Z3W
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Prolyl tripeptidyl aminopeptidase mutant E636A
分子名称: Dipeptidyl aminopeptidase IV, GLYCEROL, SULFATE ION
著者Xu, Y, Nakajima, Y, Ito, K, Yoshimoto, T.
登録日2007-06-07
公開日2008-02-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism
J.Mol.Biol., 375, 2008

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