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PDB: 142 件
1JNX
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Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
分子名称: BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, NICKEL (II) ION
著者Williams, R.S, Green, R, Glover, J.N.M.
登録日2001-07-26
公開日2001-09-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Nat.Struct.Biol., 8, 2001
4U4A
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Complex Structure of BRCA1 BRCT with singly phospho Abraxas
分子名称: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
著者Badgujar, D, Hosur, M.V, Varma, A.K.
登録日2014-07-23
公開日2015-08-26
実験手法X-RAY DIFFRACTION (3.51 Å)
主引用文献Complex Structure of BRCA1 BRCT with singly phospho Abraxas
To Be Published
1WF6
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The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product
分子名称: Similar to S.pombe -rad4+/cut5+product (A40727)
著者Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-05-26
公開日2004-11-26
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product
TO BE PUBLISHED
4JLU
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Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
分子名称: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
著者Badgujar, D, Varma, A.K.
登録日2013-03-13
公開日2014-09-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
To be Published
1OQA
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Solution structure of the BRCT-c domain from human BRCA1
分子名称: Breast cancer type 1 susceptibility protein
著者Gaiser, O.J, Ball, L.J, Schmieder, P, Leitner, D, Strauss, H, Wahl, M, Kuhne, R, Oschkinat, H, Heinemann, U.
登録日2003-03-07
公開日2004-06-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.
Biochemistry, 43, 2004
4IGK
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Structure of human BRCA1 BRCT in complex with ATRIP peptide
分子名称: ATRIP peptide, Breast cancer type 1 susceptibility protein, GLYCEROL
著者Liu, X, Ladias, J.A.A.
登録日2012-12-17
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Biochemistry, 52, 2013
3FA2
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Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains
分子名称: BRCA1-associated RING domain protein 1, GLYCEROL, PHOSPHATE ION
著者Fox III, D, Le Trong, I, Stenkamp, R.E, Klevit, R.E.
登録日2008-11-14
公開日2008-12-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains
TO BE PUBLISHED
4IFI
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Structure of human BRCA1 BRCT in complex with BAAT peptide
分子名称: ACETATE ION, BAAT peptide, Breast cancer type 1 susceptibility protein
著者Liu, X, Ladias, J.A.A.
登録日2012-12-14
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Biochemistry, 52, 2013
7CMZ
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Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8
分子名称: DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ...
著者Che, S.Y, Ma, S, Cao, C, Yao, Z, Shi, L, Yang, N.
登録日2020-07-29
公開日2021-03-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.695 Å)
主引用文献PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.
Sci Adv, 7, 2021
7P0L
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Crystal structure of S.pombe Mdb1 BRCT domains in complex with a H2A phosphopeptide
分子名称: DNA damage response protein Mdb1, Histone H2A-beta
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2021-06-29
公開日2021-12-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
6RML
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Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
2XNH
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Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
分子名称: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, IODIDE ION
著者Rappas, M, Oliver, A.W, Pearl, L.H.
登録日2010-08-02
公開日2010-09-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
7P0J
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Crystal structure of S.pombe Mdb1 BRCT domains
分子名称: CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ...
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2021-06-29
公開日2022-07-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
1CDZ
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BRCT DOMAIN FROM DNA-REPAIR PROTEIN XRCC1
分子名称: PROTEIN (DNA-REPAIR PROTEIN XRCC1)
著者Zhang, X, Morera, S, Bates, P, Whitehead, P, Coffer, A, Hainbucher, K, Nash, R, Sternberg, M, Lindahl, T, Freemont, P.
登録日1999-03-04
公開日2000-02-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.
EMBO J., 17, 1998
6RMM
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Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
6WH2
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Structure of the C-terminal BRCT domain of human XRCC1
分子名称: X-ray repair cross complementing protein 1 variant
著者Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K.
登録日2020-04-07
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.414 Å)
主引用文献An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
4OFB
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Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor
分子名称: Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor
著者Sun, L, Edwards, R.A, Glover, J.N.M.
登録日2014-01-14
公開日2015-04-15
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
Acs Chem.Biol., 10, 2015
6M14
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Crystal Structure of the BARD1 BRCT Mutant
分子名称: BRCA1-associated RING domain protein 1, SULFATE ION
著者Chen, T, Huang, W.T.
登録日2020-02-24
公開日2021-02-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.88001835 Å)
主引用文献BARD1 is an ATPase activating protein for OLA1.
Biochim Biophys Acta Gen Subj, 1866, 2022
2XNK
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Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
分子名称: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, GLYCEROL
著者Rappas, M, Oliver, A.W, Pearl, L.H.
登録日2010-08-03
公開日2010-09-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
1Z56
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Co-Crystal Structure of Lif1p-Lig4p
分子名称: DNA ligase IV, Ligase interacting factor 1
著者Dore, A.S, Furnham, N, Davies, O.R, Sibanda, B.L, Chirgadze, D.Y, Jackson, S.P, Pellegrini, L, Blundell, T.L.
登録日2005-03-17
公開日2006-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.92 Å)
主引用文献Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
2R1Z
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Crystal Structure of the BARD1 BRCT Repeat
分子名称: BRCA1-associated RING domain protein 1, GLYCEROL
著者Lee, M.S, Edwards, R.A, Williams, R.S, Glover, M.J.N.
登録日2007-08-23
公開日2007-09-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of the BARD1 BRCT Repeat
To be Published
2NTE
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Crystal Structure of the BARD1 BRCT Domains
分子名称: 1,2-ETHANEDIOL, BRCA1-associated RING domain protein 1, CHLORIDE ION, ...
著者Birrane, G, Varma, A.K, Soni, A, Ladias, J.A.A.
登録日2006-11-07
公開日2007-06-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the BARD1 BRCT domains.
Biochemistry, 46, 2007
1L0B
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Crystal Structure of rat Brca1 tandem-BRCT region
分子名称: BRCA1
著者Joo, W.S, Jeffrey, P.D, Cantor, S.B, Finnin, M.S, Livingston, D.M, Pavletich, N.P.
登録日2002-02-08
公開日2002-03-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
Genes Dev., 16, 2002
1L7B
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Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT
分子名称: DNA LIGASE
著者Sahota, G, Dixon, B.L, Huang, Y.P, Aramini, J, Monleon, D, Bhattacharya, D, Swapna, G.V.T, Yin, C, Xiao, R, Anderson, S, Tejero, R, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2002-03-14
公開日2003-09-16
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of the Brct Domain from Thermus Thermophilus DNA Ligase
To be Published
1N5O
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Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
著者Williams, R.S, Glover, J.N.M.
登録日2002-11-06
公開日2002-12-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
J.Biol.Chem., 278, 2003

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