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PDB: 273 件
1IG9
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BU of 1ig9 by Molmil
Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase
分子名称: 5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*(DOC))-3', CALCIUM ION, ...
著者Franklin, M.C, Wang, J, Steitz, T.A.
登録日2001-04-17
公開日2001-06-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase
Cell(Cambridge,Mass.), 105, 2001
2DTU
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BU of 2dtu by Molmil
Crystal structure of the beta hairpin loop deletion variant of RB69 gp43 in complex with DNA containing an abasic site analog
分子名称: 5'-D(*CP*GP*(3DR)P*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*GP*A)-3', DNA polymerase
著者Aller, P, Hogg, M, Konigsberg, W, Wallace, S.S, Doublie, S.
登録日2006-07-15
公開日2006-12-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family.
J.Biol.Chem., 282, 2007
7LUF
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BU of 7luf by Molmil
HSV1 polymerase ternary complex with dsDNA and PNU-183792
分子名称: DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ...
著者Hayes, R.P, Klein, D.
登録日2021-02-22
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Nat Commun, 12, 2021
2DY4
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BU of 2dy4 by Molmil
Crystal structure of RB69 GP43 in complex with DNA containing Thymine Glycol
分子名称: 5'-D(*CP*GP*(CTG)P*GP*GP*AP*AP*TP*GP*A*CP*AP*GP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*CP*TP*GP*T*CP*AP*TP*TP*CP*CP*A)-3', DNA polymerase
著者Aller, P, Rould, M.A, Hogg, M, Wallace, S.S, Doublie, S.
登録日2006-09-06
公開日2007-01-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol.
Proc.Natl.Acad.Sci.USA, 104, 2007
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
分子名称: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
著者Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
登録日2021-03-03
公開日2021-06-30
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
7N2M
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BU of 7n2m by Molmil
Crystal structure of DNA polymerase alpha catalytic core in complex with dCTP and template/primer having T-C mismatch at the post-insertion site
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*T*AP*GP*TP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), DNA polymerase alpha catalytic subunit, ...
著者Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
登録日2021-05-29
公開日2022-04-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural and functional insight into mismatch extension by human DNA polymerase alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
6ISI
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BU of 6isi by Molmil
Structure of 9N-I DNA polymerase incorporation with 3'-CL in the active site
分子名称: 3-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]propanoic acid, CALCIUM ION, DNA (5'-D(P*AP*CP*GP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
2GV9
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BU of 2gv9 by Molmil
Crystal structure of the Herpes Simplex virus type 1 DNA polymerase
分子名称: DNA polymerase, GUANIDINE, MERCURY (II) ION, ...
著者Liu, S.
登録日2006-05-02
公開日2006-05-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Crystal structure of the herpes simplex virus 1 DNA polymerase.
J.Biol.Chem., 281, 2006
6ISG
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BU of 6isg by Molmil
Structure of 9N-I DNA polymerase incorporation with dG in the active site
分子名称: CALCIUM ION, DNA (5'-D(*GP*AP*CP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*G)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.401 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6ISF
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BU of 6isf by Molmil
Structure of 9N-I DNA polymerase incorporation with dT in the active site
分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*T)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6Q4T
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BU of 6q4t by Molmil
KOD DNA pol in a closed ternary complex with 7-deaza-7-(2-(2-hydroxyethoxy)-N-(prop-2-yn-1-yl)acetamide)-2-dATP
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), DNA (5'-D(P*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
著者Kropp, H.M, Diederichs, K, Marx, A.
登録日2018-12-06
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 58, 2019
6TNY
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BU of 6tny by Molmil
Processive human polymerase delta holoenzyme
分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
著者Lancey, C, Hamdan, S.M, De Biasio, A.
登録日2019-12-10
公開日2019-12-18
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
7OMG
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BU of 7omg by Molmil
Crystal structure of KOD DNA Polymerase in a ternary complex with an Uracil containing template
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
登録日2021-05-22
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OMB
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BU of 7omb by Molmil
Crystal structure of KOD DNA Polymerase in a ternary complex with a p/t duplex containing an extended 5' single stranded template overhang
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, ...
著者Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
登録日2021-05-21
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OM3
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BU of 7om3 by Molmil
Crystal structure of KOD DNA Polymerase in a binary complex with Hypoxanthine containing template
分子名称: 1,2-ETHANEDIOL, 21nt Template, BROMIDE ION, ...
著者Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
登録日2021-05-21
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OPL
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BU of 7opl by Molmil
CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1
分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2021-06-01
公開日2021-11-10
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.12 Å)
主引用文献Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Protein Sci., 31, 2022
7UY7
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BU of 7uy7 by Molmil
Tetrahymena CST with Polymerase alpha-Primase
分子名称: DNA polymerase, Telomerase associated protein p50, Telomerase-associated protein of 19 kDa, ...
著者He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J.
登録日2022-05-06
公開日2022-07-13
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
7UY8
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BU of 7uy8 by Molmil
Tetrahymena Polymerase alpha-Primase
分子名称: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ...
著者He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J.
登録日2022-05-06
公開日2022-07-13
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
1WN7
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BU of 1wn7 by Molmil
Crystal structure of archaeal family B DNA polymerase mutant
分子名称: Family B DNA Polymerase, GLYCEROL, NICKEL (II) ION
著者Kuroita, T, Matsumura, H, Yokota, N, Hashimoto, H, Imanaka, T, Inoue, T, Kai, Y.
登録日2004-07-28
公開日2005-08-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural Mechanism for Coordination of Proofreading and Polymerase Activities in Archaeal DNA Polymerases
J.Mol.Biol., 351, 2005
8B9D
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BU of 8b9d by Molmil
Human replisome bound by Pol Alpha
分子名称: Cell division control protein 45 homolog, Claspin, DNA Molecule, ...
著者Jones, M.L, Yeeles, J.T.P.
登録日2022-10-05
公開日2023-08-09
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8B9C
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BU of 8b9c by Molmil
S. cerevisiae pol alpha - replisome complex
分子名称: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ...
著者Jones, M.L, Yeeles, J.T.P.
登録日2022-10-05
公開日2023-08-09
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8B9B
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BU of 8b9b by Molmil
S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand.
分子名称: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ...
著者Jones, M.L, Yeeles, J.T.P.
登録日2022-10-05
公開日2023-08-09
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
7RSS
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BU of 7rss by Molmil
Kod-RI incorporating DNA, n+2
分子名称: DNA polymerase, Primer, Template
著者Hajjar, M, Chim, N, Chaput, J.C.
登録日2021-08-11
公開日2022-08-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
7RSR
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BU of 7rsr by Molmil
Kod-RI incorporating PMT, n+2
分子名称: DNA polymerase, Primer, Template
著者Hajjar, M, Chim, N, Chaput, J.C.
登録日2021-08-11
公開日2022-08-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
1WNS
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BU of 1wns by Molmil
Crystal structure of family B DNA polymerase from hyperthermophilic archaeon pyrococcus kodakaraensis KOD1
分子名称: DNA POLYMERASE
著者Hashimoto, H, Inoue, T, Kai, Y, Fujiwara, S, Takagi, M, Nishioka, M, Imanaka, T.
登録日2004-08-09
公開日2004-08-17
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of DNA Polymerase from Hyperthermophilic Archaeon Pyrococcus Kodakaraensis Kod1
J.Mol.Biol., 306, 2001

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