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PDB: 1375 件
1IO9
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THERMOPHILIC CYTOCHROME P450 (CYP119) FROM SULFOLOBUS SOLFATARICUS: HIGH RESOLUTION STRUCTURAL ORIGIN OF ITS THERMOSTABILITY AND FUNCTIONAL PROPERTIES
分子名称: CYTOCHROME P450 CYP119, PROTOPORPHYRIN IX CONTAINING FE
著者Park, S.-Y, Yamane, K, Adachi, S, Shiro, Y, Sligar, S.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2001-02-08
公開日2001-03-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties.
J.Inorg.Biochem., 91, 2002
5UDA
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BU of 5uda by Molmil
Crystal structure of CYP2B6 (Y226H/K262R) in complex with a monoterpene bornane
分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, CAMPHANE, Cytochrome P450 2B6, ...
著者Shah, M.B, Halpert, J.R.
登録日2016-12-24
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Halogen-pi Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity.
ACS Chem. Biol., 12, 2017
1IO8
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Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: High resolution structural origin of its thermostability and functional properties
分子名称: CYTOCHROME P450 CYP119, PROTOPORPHYRIN IX CONTAINING FE
著者Park, S.-Y, Yamane, K, Adachi, S, Shiro, Y, Sligar, S.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2001-02-08
公開日2001-03-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties
J.Inorg.Biochem., 91, 2002
1DZ4
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ferric p450cam from pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-16
公開日2000-07-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
6UW2
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Clotrimazole bound complex of Acanthamoeba castellanii CYP51
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, GUANIDINE, Obtusifoliol 14alphademethylase, ...
著者Sharma, V, Podust, L.M.
登録日2019-11-04
公開日2020-10-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.
Mol.Pharmacol., 98, 2020
1CPT
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BU of 1cpt by Molmil
CRYSTAL STRUCTURE AND REFINEMENT OF CYTOCHROME P450-TERP AT 2.3 ANGSTROMS RESOLUTION
分子名称: CYTOCHROME P450-TERP, PROTOPORPHYRIN IX CONTAINING FE
著者Hasemann, C.A, Ravichandran, K.G, Peterson, J.A, Deisenhofer, J.
登録日1993-11-23
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution.
J.Mol.Biol., 236, 1994
1H5Z
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CYTOCHROME P450 14 ALPHA-STEROL DEMETHYLASE (CYP51) FROM MYCOBACTERIUM TUBERCULOSIS IN FERRIC LOW-SPIN STATE
分子名称: CYTOCHROME P450 51, FE (II) ION, PROTOPORPHYRIN IX CONTAINING FE
著者Podust, L.M, Arase, M, Waterman, M.R.
登録日2001-05-31
公開日2003-10-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Estriol Bound and Ligand-Free Structures of Sterol 14Alpha-Demethylase.
Structure, 12, 2004
5UHU
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Solution conformation of cytochrome P450 MycG with mycinamicin IV bound
分子名称: MYCINAMICIN IV, Mycinamicin IV hydroxylase/epoxidase, PROTOPORPHYRIN IX CONTAINING FE
著者Pochapsky, T.C, Tietz, D.R.
登録日2017-01-12
公開日2017-08-23
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.
Biochemistry, 56, 2017
6UX0
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Isavuconazole bound complex of Acanthamoeba castellanii CYP51
分子名称: 4-{2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl}benzonitrile, FE (III) ION, Obtusifoliol 14alphademethylase, ...
著者Sharma, V, Podust, L.M.
登録日2019-11-06
公開日2020-10-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.
Mol.Pharmacol., 98, 2020
1FAG
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STRUCTURE OF CYTOCHROME P450
分子名称: CYTOCHROME P450 BM-3, PALMITOLEIC ACID, PROTOPORPHYRIN IX CONTAINING FE
著者Li, H.Y, Poulos, T.L.
登録日1996-08-01
公開日1997-02-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid.
Nat.Struct.Biol., 4, 1997
6UPI
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Crystal structure of Mycobacterium tuberculosis CYP121 bound with a hydroxylated intermediate of cYF-4-OMe
分子名称: (3S,6S)-3-{[4-(hydroxymethoxy)phenyl]methyl}-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE
著者Nguyen, R.C.D, Yang, Y, Liu, A.
登録日2019-10-17
公開日2020-04-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.808 Å)
主引用文献Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121
Acs Catalysis, 10, 2020
1CMJ
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CRYSTAL STRUCTURES OF FERRIC-NO COMPLEXES OF FUNGAL NITRIC OXIDE REDUCTASE AND THEIR SER286 MUTANTS AT CRYOGENIC TEMPERATURE
分子名称: CYTOCHROME P450, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE
著者Park, S.-Y, Shiro, Y.
登録日1999-05-07
公開日2000-03-22
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.
J.Biol.Chem., 275, 2000
5TZ1
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Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1)
分子名称: (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, PROTOPORPHYRIN IX CONTAINING FE, Sterol 14-alpha demethylase
著者Hargrove, T, Wawrzak, Z, Lepesheva, G.
登録日2016-11-21
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
J. Biol. Chem., 292, 2017
5U6T
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BU of 5u6t by Molmil
The crystal structure of 4-ethoxybenzoate-bound CYP199A4
分子名称: 4-ethoxybenzoic acid, CHLORIDE ION, Cytochrome P450, ...
著者Coleman, T, Bruning, J.B, Bell, S.G.
登録日2016-12-08
公開日2018-06-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.935 Å)
主引用文献Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation
Acs Catalysis, 8, 2018
6VBY
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Cinnamate 4-hydroxylase (C4H1) from Sorghum bicolor
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cinnamic acid 4-hydroxylase, GLYCEROL, ...
著者Zhang, B, Kang, C, Lewis, K.M.
登録日2019-12-19
公開日2020-05-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and Function of the Cytochrome P450 Monooxygenase Cinnamate 4-hydroxylase fromSorghum bicolor.
Plant Physiol., 183, 2020
1CL6
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BU of 1cl6 by Molmil
CRYSTAL STRUCTURES OF FERRIC-NO COMPLEXES OF FUNGAL NITRIC OXIDE REDUCTASE AND ITS SER286 MUTANTS AT CRYOGENIC TEMPERATURE
分子名称: CYTOCHROME P450, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE
著者Park, S.-Y, Shiro, Y.
登録日1999-05-06
公開日2000-03-22
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.
J.Biol.Chem., 275, 2000
5TFU
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Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex
分子名称: (4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Hsu, M.H, Johnson, E.F.
登録日2016-09-26
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
1DZ8
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oxygen complex of p450cam from pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-18
公開日2000-03-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
1DZ6
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ferrous p450cam from pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-18
公開日2000-03-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
1DZ9
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Putative oxo complex of P450cam from Pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-18
公開日2000-03-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
5TE8
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Crystal structure of the midazolam-bound human CYP3A4
分子名称: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
著者Sevrioukova, I, Poulos, T.
登録日2016-09-20
公開日2016-12-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5T6Q
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Structure of cytochrome P450 4B1 (CYP4B1) complexed with octane: An n-Alkane and fatty acid omega-hydroxylase with a covalently bound heme
分子名称: Cytochrome P450 4B1, N-OCTANE, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M, Johnson, E.F.
登録日2016-09-01
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for omega-Hydroxylation.
J. Biol. Chem., 292, 2017
6VLT
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Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Shah, M.B.
登録日2020-01-25
公開日2020-09-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism.
Mol.Pharmacol., 98, 2020
5VCC
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Crystal structure of human CYP3A4 bound to glycerol
分子名称: 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ...
著者Sevrioukova, I.
登録日2017-03-31
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.
Biochemistry, 56, 2017
6VJX
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The crystal structure of 4-isobutylbenzoic acid-bound CYP199A4
分子名称: 4-(2-methylpropyl)benzoic acid, CHLORIDE ION, Cytochrome P450, ...
著者Doherty, Z.D, Bell, S.G, Bruning, J.
登録日2020-01-18
公開日2021-01-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.788 Å)
主引用文献The crystal structure of 4-isobutylbenzoic acid-bound CYP199A4
To Be Published

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件を2024-09-11に公開中

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