6UPI

Crystal structure of Mycobacterium tuberculosis CYP121 bound with a hydroxylated intermediate of cYF-4-OMe

Summary for 6UPI

Entry DOI	10.2210/pdb6upi/pdb
Descriptor	Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, (3S,6S)-3-{[4-(hydroxymethoxy)phenyl]methyl}-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione, ... (4 entities in total)
Functional Keywords	intermediate, complex, p450, hydroxylation, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	44147.53
Authors	Nguyen, R.C.D.,Yang, Y.,Liu, A. (deposition date: 2019-10-17, release date: 2020-04-29, Last modification date: 2023-10-11)
Primary citation	Nguyen, R.C.,Yang, Y.,Davis, I.,Liu, A. Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121 Acs Catalysis, 10:1628-1639, 2020 Cited by DOI: 10.1021/acscatal.9b04596 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.808 Å)

Structure validation