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PDB: 663 件

5ICT
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Crystal structure of the Drosophila GluR1A ligand binding domain Y792T mutant complex with glutamate
分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 1
著者Dharkar, P, Mayer, M.L.
登録日2016-02-23
公開日2016-12-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Novel Functional Properties of Drosophila CNS Glutamate Receptors.
Neuron, 92, 2016
5I58
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GLUTAMATE- AND GLYCINE-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH MPX-004
分子名称: 5-({[(3-chloro-4-fluorophenyl)sulfonyl]amino}methyl)-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ...
著者Mou, T.-C, Sprang, S.R, Hansen, K.B.
登録日2016-02-14
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
5I57
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Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains
分子名称: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ...
著者Mou, T.-C, Sprang, S.R, Hansen, K.B.
登録日2016-02-14
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
5IOV
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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine/Ro25-6981-bound conformation
分子名称: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, GLUTAMIC ACID, GLYCINE, ...
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E.
登録日2016-03-09
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5IPV
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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 1
分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, McHaourab, S.H, Gouaux, E.
登録日2016-03-10
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (9.25 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5IPR
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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 3
分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E.
登録日2016-03-09
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (14.1 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5IPQ
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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 2
分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E.
登録日2016-03-09
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (13.5 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5H8H
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Structure of the human GluN1/GluN2A LBD in complex with GNE3419
分子名称: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ACETATE ION, CALCIUM ION, ...
著者Wallweber, H.J.A, Lupardus, P.J.
登録日2015-12-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5IKB
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Crystal structure of the kainate receptor GluK4 ligand binding domain in complex with kainate
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLYCEROL, Glutamate receptor ionotropic, ...
著者Kristensen, O, Kristensen, L.B, Frydenvang, K, Kastrup, J.S.
登録日2016-03-03
公開日2016-08-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate.
Structure, 24, 2016
5H8F
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Structure of the apo human GluN1/GluN2A LBD
分子名称: GLUTAMIC ACID, GLYCEROL, GLYCINE, ...
著者Wallweber, H.J.A, Lupardus, P.J.
登録日2015-12-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5H8S
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Structure of the human GluA2 LBD in complex with GNE3419
分子名称: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, CACODYLATE ION, GLUTAMIC ACID, ...
著者Wallweber, H.J.A, Lupardus, P.J.
登録日2015-12-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.703 Å)
主引用文献Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5H8Q
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Structure of the human GluN1/GluN2A LBD in complex with GNE8324
分子名称: 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one, ACETATE ION, GLUTAMIC ACID, ...
著者Wallweber, H.J.A, Lupardus, P.J.
登録日2015-12-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89, 2016
5IOU
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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation
分子名称: GLUTAMIC ACID, GLYCINE, Ionotropic glutamate receptor subunit NR2B, ...
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E.
登録日2016-03-09
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (7 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5IPU
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Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6
分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E.
登録日2016-03-09
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (15.4 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5I2K
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Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19)
分子名称: 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, GLUTAMIC ACID, GLYCINE, ...
著者Wallweber, H.J.A, Lupardus, P.J.
登録日2016-02-09
公開日2016-03-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5FTI
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Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form)
分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, GLYCEROL, ...
著者Nayeem, N, Green, T.
登録日2016-01-13
公開日2016-02-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Distinct Structural Pathways Coordinate the Activation of Ampa Receptor-Auxiliary Subunit Complexes.
Neuron, 89, 2016
3FVG
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Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with MSVIII-19 in space group P1
分子名称: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ...
著者Unno, M, Sasaki, M, Ikeda-Saito, M.
登録日2009-01-15
公開日2010-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3G3G
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Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at 1.3 Angstrom resolution
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Chaudhry, C, Mayer, M.L.
登録日2009-02-02
公開日2009-06-02
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.303 Å)
主引用文献Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.
Embo J., 28, 2009
3G3I
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Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with glutamate and NaCl at 1.37 Angstrom resolution
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Chaudhry, C, Mayer, M.L.
登録日2009-02-02
公開日2009-06-02
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.371 Å)
主引用文献Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.
Embo J., 28, 2009
3GBA
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X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A resolution
分子名称: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
著者Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S.
登録日2009-02-19
公開日2009-03-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine
J.Biol.Chem., 284, 2009
3GBB
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X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution
分子名称: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, Glutamate receptor, ionotropic kainate 1
著者Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S.
登録日2009-02-19
公開日2009-03-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine
J.Biol.Chem., 284, 2009
3H06
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Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282
分子名称: 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid, Glutamate receptor 2
著者Ahmed, A.H, Oswald, R.E.
登録日2009-04-08
公開日2009-05-05
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48, 2009
3H03
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Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277
分子名称: 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2009-04-08
公開日2009-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48, 2009
3H6W
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Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution
分子名称: (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ...
著者Hald, H, Gajhede, M, Kastrup, J.S.
登録日2009-04-24
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
J.Mol.Biol., 391, 2009
3G3H
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Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Chaudhry, C, Mayer, M.L.
登録日2009-02-02
公開日2009-06-02
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.
Embo J., 28, 2009

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