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PDB: 61 件
4N4S
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A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor
分子名称: 3-[2-(benzyloxy)-8-methylquinolin-6-yl]-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Mitogen-activated protein kinase 1
著者Hari, S.B, Maly, D.J, Merritt, E.A.
登録日2013-10-08
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases.
Chem.Biol., 21, 2014
5UMO
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STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE
分子名称: Mitogen-activated protein kinase 1, SULFATE ION
著者CHLEBOWICZ, J, ZHANG, F, GOLDSMITH, E.J.
登録日2017-01-27
公開日2017-03-01
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature, 367, 1994
2ERK
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PHOSPHORYLATED MAP KINASE ERK2
分子名称: EXTRACELLULAR SIGNAL-REGULATED KINASE 2
著者Canagarajah, B.J, Goldsmith, E.J.
登録日1997-06-26
公開日1998-07-01
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell(Cambridge,Mass.), 90, 1997
2Z7L
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Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid
分子名称: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ...
著者Katayama, N, Kurihara, H.
登録日2007-08-27
公開日2008-08-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors
Proteins, 73, 2008
4S34
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ERK2 (I84A) in complex with AMP-PNP
分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Livnah, O, Karamansha, Y, Tzarum, N.
登録日2015-01-26
公開日2016-01-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Multiple mechanisms render Erk proteins MEK-independent
To be Published
2FYS
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Crystal structure of Erk2 complex with KIM peptide derived from MKP3
分子名称: Dual specificity protein phosphatase 6, Mitogen-activated protein kinase 1
著者Liu, S, Sun, J.P, Zhou, B, Zhang, Z.Y.
登録日2006-02-08
公開日2006-04-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3
Proc.Natl.Acad.Sci.Usa, 103, 2006
3C9W
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Crystal Structure of ERK-2 with hypothemycin covalently bound
分子名称: (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione, Mitogen-activated protein kinase 1
著者Rosenfeld, R.J.
登録日2008-02-18
公開日2008-07-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular modeling and crystal structure of ERK2-hypothemycin complexes
J.Struct.Biol., 164, 2008
6OPK
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Phosphorylated ERK2 with Vertex-11e
分子名称: 4-{2-[(2-chloro-4-fluorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide, Mitogen-activated protein kinase 1
著者Vigers, G.P, Rudolph, J.
登録日2019-04-25
公開日2019-07-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
4XRL
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Crystal structure at room temperature of Erk2 in complex with an inhibitor
分子名称: 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, Mitogen-activated protein kinase 1, SULFATE ION
著者Gelin, M, Allemand, F, Labesse, G, Guichou, J.F.
登録日2015-01-21
公開日2016-03-23
最終更新日2016-03-30
実験手法X-RAY DIFFRACTION (2.554 Å)
主引用文献Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
3ZUV
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Crystal structure of a designed selected Ankyrin Repeat protein in complex with the phosphorylated MAP kinase ERK2
分子名称: DESIGNED ANKYRIN REPEAT PROTEIN, MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION
著者Kummer, L, Mittl, P.R, Pluckthun, A.
登録日2011-07-20
公開日2012-06-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Proc.Natl.Acad.Sci.USA, 109, 2012
1GOL
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COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
分子名称: ADENOSINE-5'-TRIPHOSPHATE, EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION
著者Harkins, P.C, Zhang, F, Goldsmith, E.J.
登録日1996-01-23
公開日1997-03-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry, 35, 1996
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