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PDB: 80 件
1M40
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ULTRA HIGH RESOLUTION CRYSTAL STRUCTURE OF TEM-1
分子名称: BETA-LACTAMASE TEM, PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ...
著者Minasov, G, Wang, X, Shoichet, B.K.
登録日2002-07-01
公開日2002-07-17
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (0.85 Å)
主引用文献An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation.
J.Am.Chem.Soc., 124, 2002
4ID4
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Crystal structure of chimeric beta-lactamase cTEM-17m
分子名称: Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ...
著者Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M.
登録日2012-12-11
公開日2013-12-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins.
Chem.Biol., 21, 2014
4R4S
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Crystal structure of chimeric beta-lactamase cTEM-19m at 1.1 angstrom resolution
分子名称: Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION
著者Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M.
登録日2014-08-19
公開日2015-11-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.
Sci Rep, 9, 2019
4QY6
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Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
分子名称: Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ...
著者Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M.
登録日2014-07-23
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
To be Published
4R4R
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Crystal structure of chimeric beta-lactamase cTEM-19m at 1.2 angstrom resolution
分子名称: Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION
著者Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M.
登録日2014-08-19
公開日2015-11-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.
Sci Rep, 9, 2019
1NYM
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Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (CXB)
分子名称: Beta-lactamase TEM, PHOSPHATE ION, POTASSIUM ION, ...
著者Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K.
登録日2003-02-12
公開日2003-08-26
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Recognition and resistance in TEM beta-lactamase
Biochemistry, 42, 2003
4RX3
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A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis
分子名称: Beta-lactamase TEM, CITRATE ANION
著者Stojanoski, V, Chow, D, Hu, L, Sankaran, B, Gilbert, H, Prasad, B.V.V, Palzkill, T.
登録日2014-12-08
公開日2015-03-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis.
J.Biol.Chem., 290, 2015
1YT4
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Crystal structure of TEM-76 beta-lactamase at 1.4 Angstrom resolution
分子名称: Beta-lactamase TEM
著者Thomas, V.L, Golemi-Kotra, D, Kim, C, Vakulenko, S.B, Mobashery, S, Shoichet, B.K.
登録日2005-02-09
公開日2005-07-12
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM beta-Lactamase.
Biochemistry, 44, 2005
5HW5
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Crystal structure of TEM1 beta-lactamase in the presence of 2.0 MPa xenon
分子名称: Beta-lactamase TEM, XENON
著者Roose, B.W, Dmochowski, I.J.
登録日2016-01-28
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Structure of TEM1 beta-lactamase
To Be Published
4RVA
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A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for deacylation
分子名称: BICARBONATE ION, Beta-lactamase TEM
著者Stojanoski, V, Chow, D.-C, Hu, L, Sankaran, B, Gilbert, H, Prasad, B.V.V, Palzkill, T.
登録日2014-11-25
公開日2015-03-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4397 Å)
主引用文献A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis.
J.Biol.Chem., 290, 2015
6AYK
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Crystal structure of TEM1 beta-lactamase mutant I263A in the presence of 1.2 MPa xenon
分子名称: Beta-lactamase TEM, XENON
著者Roose, B.W, Dmochowski, I.J.
登録日2017-09-08
公開日2018-09-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 20, 2019
8DDZ
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BU of 8ddz by Molmil
TEM-1 beta-lactamase A237Y
分子名称: Beta-lactamase TEM
著者Ji, Z, Boxer, S.G, Mathews, I.I.
登録日2022-06-19
公開日2022-09-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases.
J.Am.Chem.Soc., 144, 2022
1PZP
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TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor
分子名称: 3-(4-PHENYLAMINO-PHENYLAMINO)-2-(1H-TETRAZOL-5-YL)-ACRYLONITRILE, Beta-lactamase TEM
著者Horn, J.R, Shoichet, B.K.
登録日2003-07-14
公開日2004-03-09
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Allosteric inhibition through core disruption.
J.Mol.Biol., 336, 2004
5KPU
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Crystal structure of TEM1 beta-lactamase mutant I263L in the presence of 1.2 MPa xenon
分子名称: Beta-lactamase TEM, XENON
著者Roose, B.W, Dmochowski, I.J.
登録日2016-07-05
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 2018
4QY5
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BU of 4qy5 by Molmil
Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
分子名称: Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION
著者Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M.
登録日2014-07-23
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
To be Published
1LI9
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Crystal structure of TEM-34 beta-Lactamase at 1.5 Angstrom
分子名称: Class A beta-Lactamase- TEM-34, PHOSPHATE ION, POTASSIUM ION
著者Wang, X, Minasov, G, Shoichet, B.K.
登録日2002-04-17
公開日2002-09-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34.
J.Biol.Chem., 277, 2002
4ZJ1
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Crystal Structure of p-acrylamido-phenylalanine modified TEM1 beta-lactamase from Escherichia coli : V216AcrF mutant
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase TEM, DI(HYDROXYETHYL)ETHER, ...
著者Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, R.C, Schultz, P.G.
登録日2015-04-28
公開日2015-05-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Exploring the potential impact of an expanded genetic code on protein function.
Proc.Natl.Acad.Sci.USA, 112, 2015
1ZG4
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TEM1 beta lactamase
分子名称: Beta-lactamase TEM
著者Stec, B, Holtz, K.M, Wojciechowski, C.L, Kantrowitz, E.R.
登録日2005-04-20
公開日2005-05-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure of the wild-type TEM-1 beta-lactamase at 1.55 A and the mutant enzyme Ser70Ala at 2.1 A suggest the mode of noncovalent catalysis for the mutant enzyme.
Acta Crystallogr.,Sect.D, 61, 2005
8DE1
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TEM-1 beta-lactamase A237Y mutant covalently bound to avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase TEM
著者Ji, Z, Boxer, S.G, Mathews, I.I.
登録日2022-06-19
公開日2022-09-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases.
J.Am.Chem.Soc., 144, 2022
2V1Z
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BU of 2v1z by Molmil
Structure of a TEM-1 beta-lactamase insertant allosterically regulated by kanamycin and anions.
分子名称: BETA-LACTAMASE TEM, ZINC ION
著者Evrard, C, Barrios, H, Mathonet, P, Soumillion, P, Fastrez, J, Declercq, J.P.
登録日2007-05-31
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Engineering an Allosteric Binding Site for Aminoglycosides Into Tem1-Beta-Lactamase.
Chembiochem, 12, 2011
1NXY
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Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (SM2)
分子名称: (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase TEM, POTASSIUM ION
著者Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K.
登録日2003-02-11
公開日2003-08-26
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Recognition and Resistance in TEM beta-lactamase
Biochemistry, 42, 2003
1LI0
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Crystal structure of TEM-32 beta-Lactamase at 1.6 Angstrom
分子名称: BICARBONATE ION, Class A beta-Lactamase- TEM-32, POTASSIUM ION
著者Wang, X, Minasov, G, Shoichet, B.K.
登録日2002-04-17
公開日2002-09-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34.
J.Biol.Chem., 277, 2002
5HVI
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Crystal structure of TEM1 beta-lactamase
分子名称: Beta-lactamase TEM
著者Roose, B.W, Dmochowski, I.J.
登録日2016-01-28
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase.
Chemphyschem, 2018
2B5R
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1B Lactamase / B Lactamase Inhibitor
分子名称: Beta-lactamase TEM, Beta-lactamase inhibitory protein
著者Rahat, O, Albeck, S, Meged, R, Dym, O, Screiber, G, Israel Structural Proteomics Center (ISPC)
登録日2005-09-29
公開日2006-04-11
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture.
J.Mol.Biol., 102, 2006
2V20
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Structure of a TEM-1 beta-lactamase insertant allosterically regulated by kanamycin and anions. Complex with sulfate.
分子名称: BETA-LACTAMASE TEM, SULFATE ION, ZINC ION
著者Evrard, C, Barrios, H, Mathonet, P, Soumillion, P, Fastrez, J, Declercq, J.P.
登録日2007-05-31
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Engineering an Allosteric Binding Site for Aminoglycosides Into Tem1-Beta-Lactamase.
Chembiochem, 12, 2011

 

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