7S1H
| Wild-type Escherichia coli ribosome with antibiotic linezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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8BHP
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8E36
| E. coli 50S ribosome bound to compound streptogramin A analog 3146 | 分子名称: | 2-[(3R,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-3-(propan-2-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-4-yl]-N-{2-[4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl]ethyl}acetamide, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-16 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | 主引用文献 | Potential for clicked streptogramin analogs To Be Published
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8W51
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9FBV
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7O1A
| Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | 著者 | van der Stel, A.X, Gordon, E.R, Sengupta, A, Martinez, A.K, Klepacki, D, Perry, T.N, Herrero del Valle, A, Vazquez-Laslop, N, Sachs, M.S, Cruz-Vera, L.R, Innis, C.A. | 登録日 | 2021-03-29 | 公開日 | 2021-09-01 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling. Nat Commun, 12, 2021
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8R8M
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8HTZ
| E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Akiyama, N, Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | 登録日 | 2022-12-22 | 公開日 | 2024-04-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine. Nat.Struct.Mol.Biol., 31, 2024
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7BL4
| in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Hilal, T, Nikolay, R, Spahn, C.M.T. | 登録日 | 2021-01-18 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7Y7E
| Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | 登録日 | 2022-06-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
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7S1K
| Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Tsai, K, Stojkovic, V, Lee, D.J, Young, I.D, Szal, T, Vazquez-Laslop, N, Mankin, A.S, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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8IFB
| Dibekacin-bound E.coli 70S ribosome in the PURE system | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. | 登録日 | 2023-02-17 | 公開日 | 2024-02-14 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. J.Biochem., 175, 2024
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7Y7F
| Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | 登録日 | 2022-06-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
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8RPZ
| Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation I | 分子名称: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | 著者 | Lauer, S, Nikolay, R, Spahn, C. | 登録日 | 2024-01-17 | 公開日 | 2024-05-22 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88. Nat Commun, 15, 2024
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8RQ0
| Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation II | 分子名称: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | 著者 | Lauer, S, Nikolay, R, Spahn, C. | 登録日 | 2024-01-17 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88. Nat Commun, 15, 2024
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8RQ2
| Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation III | 分子名称: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | 著者 | Lauer, S, Nikolay, R, Spahn, C. | 登録日 | 2024-01-17 | 公開日 | 2024-05-22 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88. Nat Commun, 15, 2024
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7S1J
| Wild-type Escherichia coli ribosome with antibiotic radezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1G
| wild-type Escherichia coli stalled ribosome with antibiotic linezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1I
| Wild-type Escherichia coli stalled ribosome with antibiotic radezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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6PCR
| E. coli 50S ribosome bound to compound 40o | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl (2-bromopyridin-4-yl)carbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PC6
| E. coli 50S ribosome bound to compound 47 | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PC7
| E. coli 50S ribosome bound to compound 46 | 分子名称: | (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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7Y7C
| Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | 登録日 | 2022-06-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
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7Y7H
| Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | 登録日 | 2022-06-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
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8E44
| E. coli 50S ribosome bound to antibiotic analog SLC09 | 分子名称: | 2-chloro-N-{[(5S)-3-{(4M)-3-fluoro-4-[(6P)-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-17 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | 主引用文献 | SLC collection of antibiotic analogs To Be Published
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