1LI4
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![BU of 1li4 by Molmil](/molmil-images/mine/1li4) | Human S-adenosylhomocysteine hydrolase complexed with neplanocin | 分子名称: | 3-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-CYCLOPENTANE-1,2-DIOL, ISOPROPYL ALCOHOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Yang, X, Hu, Y, Yin, D.H, Turner, M.A, Wang, M, Borchardt, R.T, Howell, P.L, Kuczera, K, Schowen, R.L. | 登録日 | 2002-04-17 | 公開日 | 2003-05-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: Transition-state
stabilization and the avoidance of abortive reactions Biochemistry, 42, 2003
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4PFJ
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![BU of 4pfj by Molmil](/molmil-images/mine/4pfj) | The structure of bi-acetylated SAHH | 分子名称: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | 登録日 | 2014-04-29 | 公開日 | 2014-10-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. J.Biol.Chem., 289, 2014
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5W49
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![BU of 5w49 by Molmil](/molmil-images/mine/5w49) | The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to oxadiazole inhibitor | 分子名称: | (4-amino-1,2,5-oxadiazol-3-yl)[(3R)-3-{4-[(3-methoxyphenyl)amino]-6-methylpyridin-2-yl}pyrrolidin-1-yl]methanone, 1,2-ETHANEDIOL, Adenosylhomocysteinase, ... | 著者 | Dougan, D.R, Lawson, J.D, Lane, W. | 登録日 | 2017-06-09 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of AHCY inhibitors using novel high-throughput mass spectrometry. Biochem. Biophys. Res. Commun., 491, 2017
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3NJ4
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![BU of 3nj4 by Molmil](/molmil-images/mine/3nj4) | Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase | 分子名称: | (4S,5S)-4-(6-amino-9H-purin-9-yl)-3-fluoro-5-hydroxy-2-(hydroxymethyl)cyclopent-2-en-1-one, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Jeong, L.S, Lee, K.M, Hwang, K.Y, Choi, S, Heo, Y.S. | 登録日 | 2010-06-17 | 公開日 | 2011-05-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues. J.Med.Chem., 54, 2011
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4PGF
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![BU of 4pgf by Molmil](/molmil-images/mine/4pgf) | The structure of mono-acetylated SAHH | 分子名称: | ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J. | 登録日 | 2014-05-01 | 公開日 | 2014-10-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. J.Biol.Chem., 289, 2014
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5W4B
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![BU of 5w4b by Molmil](/molmil-images/mine/5w4b) | The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to benzothiazole inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-[(2,5-dioxo-2,5-dihydro-1H-imidazol-1-yl)methyl]-N-[2-(morpholin-4-yl)-1,3-benzothiazol-6-yl]benzamide, Adenosylhomocysteinase, ... | 著者 | Dougan, D.R, Lawson, J.D, Lane, W. | 登録日 | 2017-06-09 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Identification of AHCY inhibitors using novel high-throughput mass spectrometry. Biochem. Biophys. Res. Commun., 491, 2017
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4YVF
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![BU of 4yvf by Molmil](/molmil-images/mine/4yvf) | Structure of S-adenosyl-L-homocysteine hydrolase | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{[5-chloro-2-(4-chlorophenoxy)phenyl](2-{[2-(methylamino)ethyl]amino}-2-oxoethyl)amino}-N-(1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide, Adenosylhomocysteinase | 著者 | Akiko, K. | 登録日 | 2015-03-20 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs. Bioorg.Med.Chem., 23, 2015
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1A7A
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![BU of 1a7a by Molmil](/molmil-images/mine/1a7a) | STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH | 分子名称: | (1'R,2'S)-9-(2-HYDROXY-3'-KETO-CYCLOPENTEN-1-YL)ADENINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYLHOMOCYSTEINE HYDROLASE | 著者 | Turner, M.A, Yuan, C.-S, Borchardt, R.T, Hershfield, M.S, Smith, G.D, Howell, P.L. | 登録日 | 1998-03-10 | 公開日 | 1999-04-20 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength. Nat.Struct.Biol., 5, 1998
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