5W4B

The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to benzothiazole inhibitor

Summary for 5W4B

• Entry DOI: 10.2210/pdb5w4b/pdb
• Related: 5W49
• Descriptor: Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-[(2,5-dioxo-2,5-dihydro-1H-imidazol-1-yl)methyl]-N-[2-(morpholin-4-yl)-1,3-benzothiazol-6-yl]benzamide, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P23526
• Total number of polymer chains: 6
• Total formula weight: 291377.10

Authors

Dougan, D.R.,Lawson, J.D.,Lane, W. (deposition date: 2017-06-09, release date: 2017-06-28, Last modification date: 2024-03-13)

• Primary citation: Uchiyama, N.,Dougan, D.R.,Lawson, J.D.,Kimura, H.,Matsumoto, S.I.,Tanaka, Y.,Kawamoto, T.; Identification of AHCY inhibitors using novel high-throughput mass spectrometry.; Biochem. Biophys. Res. Commun., 491:1-7, 2017; PubMed: 28533090; DOI: 10.1016/j.bbrc.2017.05.107

Experimental method

X-RAY DIFFRACTION (2.65 Å)