1LI4
Human S-adenosylhomocysteine hydrolase complexed with neplanocin
Summary for 1LI4
Entry DOI | 10.2210/pdb1li4/pdb |
Descriptor | S-adenosylhomocysteine hydrolase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-CYCLOPENTANE-1,2-DIOL, ... (5 entities in total) |
Functional Keywords | alpha-beta structure, inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P23526 |
Total number of polymer chains | 1 |
Total formula weight | 48821.84 |
Authors | Yang, X.,Hu, Y.,Yin, D.H.,Turner, M.A.,Wang, M.,Borchardt, R.T.,Howell, P.L.,Kuczera, K.,Schowen, R.L. (deposition date: 2002-04-17, release date: 2003-05-20, Last modification date: 2023-08-16) |
Primary citation | Yang, X.,Hu, Y.,Yin, D.H.,Turner, M.A.,Wang, M.,Borchardt, R.T.,Howell, P.L.,Kuczera, K.,Schowen, R.L. Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: Transition-state stabilization and the avoidance of abortive reactions Biochemistry, 42:1900-1909, 2003 Cited by PubMed: 12590576DOI: 10.1021/bi0262350 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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