Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004013 | molecular_function | adenosylhomocysteinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033353 | biological_process | S-adenosylmethionine cycle |
| A | 0042470 | cellular_component | melanosome |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD A 433 |
| Chain | Residue |
| A | THR157 |
| A | THR242 |
| A | GLU243 |
| A | ILE244 |
| A | ASP245 |
| A | ASN248 |
| A | THR275 |
| A | THR276 |
| A | CYS278 |
| A | ILE281 |
| A | ILE299 |
| A | THR158 |
| A | GLY300 |
| A | HIS301 |
| A | LEU344 |
| A | ASN346 |
| A | HIS353 |
| A | LYS426 |
| A | TYR430 |
| A | NOC434 |
| A | HOH903 |
| A | HOH929 |
| A | THR159 |
| A | HOH930 |
| A | HOH938 |
| A | HOH998 |
| A | ASP190 |
| A | ASN191 |
| A | GLY220 |
| A | GLY222 |
| A | ASP223 |
| A | VAL224 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NOC A 434 |
| Chain | Residue |
| A | HIS55 |
| A | THR57 |
| A | GLU59 |
| A | THR60 |
| A | ASP131 |
| A | GLU156 |
| A | THR157 |
| A | LYS186 |
| A | ASP190 |
| A | HIS301 |
| A | MET351 |
| A | GLY352 |
| A | HIS353 |
| A | MET358 |
| A | PHE362 |
| A | NAD433 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IPA A 900 |
| Chain | Residue |
| A | ARG238 |
| A | ALA253 |
| A | TYR257 |
| A | VAL259 |
| A | LEU402 |
| A | HOH1039 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 901 |
| Chain | Residue |
| A | GLN85 |
| A | ASP86 |
| A | HIS87 |
Functional Information from PROSITE/UniProt
| site_id | PS00738 |
| Number of Residues | 15 |
| Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDhAAAAI |
| Chain | Residue | Details |
| A | SER78-ILE92 | |
| site_id | PS00739 |
| Number of Residues | 17 |
| Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKvavVaGYGdVGKGc.A |
| Chain | Residue | Details |
| A | GLY213-ALA229 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P10760","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12590576","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9586999","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"29192674","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P50247","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1b3r |
| Chain | Residue | Details |
| A | CYS195 | |
| A | LYS186 | |
| A | ASP131 | |
| A | ASN191 | |
| A | HIS55 | |
| A | ASP190 | |
| A | HIS301 | |
