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PDB: 16 件
1PJ3
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Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate.
分子名称: FUMARIC ACID, MANGANESE (II) ION, NAD-dependent malic enzyme, ...
著者Tao, X, Yang, Z, Tong, L.
登録日2003-05-30
公開日2003-11-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11, 2003
1QR6
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HUMAN MITOCHONDRIAL NAD(P)-DEPENDENT MALIC ENZYME
分子名称: MALIC ENZYME 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Xu, Y, Bhargava, G, Wu, H, Loeber, G, Tong, L.
登録日1999-06-18
公開日1999-07-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases.
Structure, 7, 1999
1DO8
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BU of 1do8 by Molmil
CRYSTAL STRUCTURE OF A CLOSED FORM OF HUMAN MITOCHONDRIAL NAD(P)+-DEPENDENT MALIC ENZYME
分子名称: MALIC ENZYME, MANGANESE (II) ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Yang, Z, Floyd, D.L, Loeber, G, Tong, L.
登録日1999-12-19
公開日2000-03-06
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of a closed form of human malic enzyme and implications for catalytic mechanism.
Nat.Struct.Biol., 7, 2000
1GZ4
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molecular mechanism of the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate
分子名称: ADENOSINE-5'-TRIPHOSPHATE, FUMARIC ACID, MANGANESE (II) ION, ...
著者Yang, Z, Lanks, C.W, Tong, L.
登録日2002-05-15
公開日2002-07-25
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular Mechanism for the Regulation of Human Mitochondrial Nad(P)(+)-Dependent Malic Enzyme by ATP and Fumarate
Structure, 10, 2002
1PJ4
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BU of 1pj4 by Molmil
Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, ATP, Mn++, and allosteric activator fumarate.
分子名称: ADENOSINE-5'-TRIPHOSPHATE, D-MALATE, FUMARIC ACID, ...
著者Tao, X, Yang, Z, Tong, L.
登録日2003-05-31
公開日2003-09-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11, 2003
1PJ2
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BU of 1pj2 by Molmil
Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor NADH, Mn++, and allosteric activator fumarate
分子名称: (2S)-2-hydroxybutanedioic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FUMARIC ACID, ...
著者Tao, X, Yang, Z, Tong, L.
登録日2003-05-30
公開日2003-11-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11, 2003
1GZ3
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BU of 1gz3 by Molmil
Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate
分子名称: ADENOSINE-5'-TRIPHOSPHATE, FUMARIC ACID, MANGANESE (II) ION, ...
著者Yang, Z, Lanks, C.W, Tong, L.
登録日2002-05-14
公開日2003-05-22
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Mechanism for the Regulation of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme by ATP and Fumarate
Structure, 10, 2002
7BSJ
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BU of 7bsj by Molmil
Crystal structure of human ME2 R484W
分子名称: FUMARIC ACID, MAGNESIUM ION, NAD-dependent malic enzyme, ...
著者Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C.
登録日2020-03-30
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Iscience, 24, 2021
7BSL
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BU of 7bsl by Molmil
Crystal Structure of human ME2 R67A mutant
分子名称: NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C.
登録日2020-03-30
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Iscience, 24, 2021
7BSK
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BU of 7bsk by Molmil
Crystal structure of human ME2 R67Q mutant
分子名称: NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Chen, W.L, Tai, S.C, Hung, H.C, Ho, M.C.
登録日2020-03-30
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Iscience, 24, 2021
1EFL
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BU of 1efl by Molmil
HUMAN MALIC ENZYME IN A QUATERNARY COMPLEX WITH NAD, MG, AND TARTRONATE
分子名称: MAGNESIUM ION, MALIC ENZYME, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Yang, Z, Floyd, D.L, Loeber, G, Tong, L.
登録日2000-02-09
公開日2000-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of a closed form of human malic enzyme and implications for catalytic mechanism.
Nat.Struct.Biol., 7, 2000
1EFK
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BU of 1efk by Molmil
STRUCTURE OF HUMAN MALIC ENZYME IN COMPLEX WITH KETOMALONATE
分子名称: ALPHA-KETOMALONIC ACID, MAGNESIUM ION, MALIC ENZYME, ...
著者Yang, Z, Floyd, D.L, Loeber, G, Tong, L.
登録日2000-02-09
公開日2000-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of a closed form of human malic enzyme and implications for catalytic mechanism.
Nat.Struct.Biol., 7, 2000
7XDF
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BU of 7xdf by Molmil
Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in a ternary complex with NAD+ and allosteric inhibitor EA
分子名称: 4-[(3-carboxy-2-oxidanyl-naphthalen-1-yl)methyl]-3-oxidanyl-naphthalene-2-carboxylic acid, NAD-dependent malic enzyme, mitochondrial, ...
著者Wang, C.H, Hsieh, J.T, Ho, M.C, Hung, H.C.
登録日2022-03-27
公開日2023-03-29
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (2.72 Å)
主引用文献Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Commun Biol, 6, 2023
7XDE
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BU of 7xde by Molmil
Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in apo form
分子名称: NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Wang, C.H, Hsieh, J.T, Ho, M.C, Hung, H.C.
登録日2022-03-26
公開日2023-03-29
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.72 Å)
主引用文献Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Commun Biol, 6, 2023
7XDG
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BU of 7xdg by Molmil
Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in a ternary complex with NAD+ and allosteric inhibitor MDSA
分子名称: 5-[(3-carboxy-4-oxidanyl-phenyl)methyl]-2-oxidanyl-benzoic acid, NAD-dependent malic enzyme, mitochondrial, ...
著者Wang, C.H, Hsieh, J.T, Ho, M.C, Hung, H.C.
登録日2022-03-27
公開日2023-03-29
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Commun Biol, 6, 2023
1PJL
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BU of 1pjl by Molmil
Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+
分子名称: LUTETIUM (III) ION, NAD-dependent malic enzyme, mitochondrial, ...
著者Yang, Z, Batra, R, Floyd, D.L, Hung, H.-C, Chang, G.-G, Tong, L.
登録日2003-06-03
公開日2003-06-17
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Potent and competitive inhibition of malic enzymes by lanthanide ions
Biochem.Biophys.Res.Commun., 274, 2000

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件を2024-07-10に公開中

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