7NA9
 
 | | Crystal structure of BoNT/B-LC-JSG-C1 | | 分子名称: | 1,2-ETHANEDIOL, Botulinum neurotoxin type B, JSG-C1, ... | | 著者 | Lam, K, Jin, R. | | 登録日 | 2021-06-20 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
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1S0E
 | | Crystal structure of botulinum neurotoxin type B at pH 6.0 | | 分子名称: | Botulinum neurotoxin type B, CALCIUM ION, ZINC ION | | 著者 | Eswaramoorthy, S, Kumaran, D, Keller, J, Swaminathan, S. | | 登録日 | 2003-12-30 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Role of metals in the biological activity of Clostridium botulinum neurotoxins
Biochemistry, 43, 2004
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1EPW
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5VMR
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1G9B
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1Z0H
 | | N-terminal helix reorients in recombinant C-fragment of Clostridium botulinum type B | | 分子名称: | Botulinum neurotoxin type B | | 著者 | Jayaraman, S, Eswarmoorthy, S, Ashraf, S.A, Smith, L.A, Swaminathan, S. | | 登録日 | 2005-03-01 | | 公開日 | 2005-03-15 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | N-terminal helix reorients in recombinant C-fragment of Clostridium botulinum type B.
Biochem.Biophys.Res.Commun., 330, 2005
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1S0B
 | | Crystal structure of botulinum neurotoxin type B at pH 4.0 | | 分子名称: | Botulinum neurotoxin type B, CALCIUM ION | | 著者 | Eswaramoorthy, S, Kumaran, D, Keller, J, Swaminathan, S. | | 登録日 | 2003-12-30 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Role of metals in the biological activity of Clostridium botulinum neurotoxins
Biochemistry, 43, 2004
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6G5G
 | | Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 2 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | | 著者 | Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P. | | 登録日 | 2018-03-29 | | 公開日 | 2019-01-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv, 5, 2019
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6G5K
 | | Crystal structure of the binding domain of Botulinum Neurotoxin type B in complex with human synaptotagmin 1 | | 分子名称: | Botulinum neurotoxin type B, Synaptotagmin-1 | | 著者 | Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P. | | 登録日 | 2018-03-29 | | 公開日 | 2019-01-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv, 5, 2019
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1G9A
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2NM1
 | | Structure of BoNT/B in complex with its protein receptor | | 分子名称: | Botulinum neurotoxin type B, Synaptotagmin-2 | | 著者 | Jin, R, Rummel, A, Binz, T, Brunger, A.T. | | 登録日 | 2006-10-20 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
Nature, 444, 2006
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1S0D
 | | Crystal structure of botulinum neurotoxin type B at pH 5.5 | | 分子名称: | Botulinum neurotoxin type B, CALCIUM ION, ZINC ION | | 著者 | Eswaramoorthy, S, Kumaran, D, Keller, J, Swaminathan, S. | | 登録日 | 2003-12-30 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Role of metals in the biological activity of Clostridium botulinum neurotoxins
Biochemistry, 43, 2004
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1G9D
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1S0C
 | | Crystal structure of botulinum neurotoxin type B at pH 5.0 | | 分子名称: | Botulinum neurotoxin type B, CALCIUM ION, ZINC ION | | 著者 | Eswaramoorthy, S, Kumaran, D, Keller, J, Swaminathan, S. | | 登録日 | 2003-12-30 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Role of metals in the biological activity of Clostridium botulinum neurotoxins
Biochemistry, 43, 2004
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1F82
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6UHT
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2ETF
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1S0F
 | | Crystal structure of botulinum neurotoxin type B at pH 7.0 | | 分子名称: | Botulinum neurotoxin type B, CALCIUM ION, ZINC ION | | 著者 | Eswaramoorthy, S, Kumaran, D, Keller, J, Swaminathan, S. | | 登録日 | 2003-12-30 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Role of metals in the biological activity of Clostridium botulinum neurotoxins
Biochemistry, 43, 2004
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4KBB
 | | Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a | | 分子名称: | Botulinum neurotoxin type B, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Berntsson, R.P.A, Peng, L, Dong, M, Stenmark, P. | | 登録日 | 2013-04-23 | | 公開日 | 2013-07-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of dual receptor binding to botulinum neurotoxin B.
Nat Commun, 4, 2013
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6UC6
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1G9C
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6QNS
 | | Crystal structure of the binding domain of Botulinum Neurotoxin type B mutant I1248W/V1249W in complex with human synaptotagmin 1 and GD1a receptors | | 分子名称: | Botulinum neurotoxin type B, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, Synaptotagmin-1 | | 著者 | Masuyer, G, Yin, L, Zhang, S, Miyashita, S.I, Dong, M, Stenmark, P. | | 登録日 | 2019-02-12 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
Plos Biol., 18, 2020
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1I1E
 | | CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN | | 分子名称: | BOTULINUM NEUROTOXIN TYPE B, DOXORUBICIN, SULFATE ION, ... | | 著者 | Eswaramoorthy, S, Kumaran, D, Swaminathan, S. | | 登録日 | 2001-02-01 | | 公開日 | 2001-11-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B.
Acta Crystallogr.,Sect.D, 57, 2001
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6G5F
 | | Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1 | | 分子名称: | Botulinum neurotoxin type B, GLYCEROL, MALONATE ION, ... | | 著者 | Masuyer, G, Elliot, M, Favre-Guilmard, C, Liu, S.M, Maignel, J, Beard, M, Carre, D, Kalinichev, M, Lezmi, S, Mir, I, Nicoleau, C, Palan, S, Perier, C, Raban, E, Dong, M, Krupp, J, Stenmark, P. | | 登録日 | 2018-03-29 | | 公開日 | 2019-01-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Sci Adv, 5, 2019
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7T5F
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