Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 188 件
4OVZ
DownloadVisualize
BU of 4ovz by Molmil
X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
分子名称: DIMETHYL SULFOXIDE, N-[(4-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Papain-like proteinase, ...
著者Baez-Santos, Y.M, Mesecar, A.
登録日2014-01-28
公開日2014-04-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases.
J.Med.Chem., 57, 2014
3VB6
DownloadVisualize
BU of 3vb6 by Molmil
Crystal structure of SARS-CoV 3C-like protease with C6Z
分子名称: 1,2-ETHANEDIOL, 3C-like proteinase, C6Z inhibitor
著者Chuck, C.P, Wong, K.B.
登録日2011-12-31
公開日2012-12-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
Eur.J.Med.Chem., 59C, 2012
3F9E
DownloadVisualize
BU of 3f9e by Molmil
Crystal Structure of the S139A mutant of SARS-Coronovirus 3C-like Protease
分子名称: 3C-like proteinase
著者Hu, T, Li, L, Jiang, H, Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
1UK4
DownloadVisualize
BU of 1uk4 by Molmil
Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) Complexed With An Inhibitor
分子名称: 3C-like proteinase nsp5, 5-mer peptide of inhibitor
著者Yang, H, Yang, M, Liu, Y, Bartlam, M, Ding, Y, Lou, Z, Sun, L, Zhou, Z, Ye, S, Anand, K, Pang, H, Gao, G.F, Hilgenfeld, R, Rao, Z.
登録日2003-08-14
公開日2003-11-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
2PWX
DownloadVisualize
BU of 2pwx by Molmil
Crystal structure of G11A mutant of SARS-CoV 3C-like protease
分子名称: 3C-like proteinase
著者Chen, S, Hu, T, Jiang, H, Shen, X.
登録日2007-05-14
公開日2007-10-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.
J.Biol.Chem., 283, 2008
2Q6G
DownloadVisualize
BU of 2q6g by Molmil
Crystal structure of SARS-CoV main protease H41A mutant in complex with an N-terminal substrate
分子名称: Polypeptide chain, severe acute respiratory syndrome coronavirus (SARS-CoV)
著者Xue, X.Y, Yang, H.T, Xue, F, Bartlam, M, Rao, Z.H.
登録日2007-06-05
公開日2008-02-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
J.Virol., 82, 2008
8UFL
DownloadVisualize
BU of 8ufl by Molmil
Crystal Structure of SARS-Unique Domain (SUD) of Nsp3 from SARS coronavirus
分子名称: CHLORIDE ION, Papain-like protease nsp3, SULFATE ION
著者Minasov, G, Shuvalova, L, Rosas-Lemus, M, Kiryukhina, O, Brunzelle, J.S, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2023-10-04
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Crystal Structure of SARS-Unique Domain (SUD) of Nsp3 from SARS coronavirus
To Be Published
7ZQW
DownloadVisualize
BU of 7zqw by Molmil
Structure of the SARS-CoV-1 main protease in complex with AG7404
分子名称: 3C-like proteinase nsp5, ethyl (4R)-4-({(2S)-2-[3-{[(5-methyl-1,2-oxazol-3-yl)carbonyl]amino}-2-oxopyridin-1(2H)-yl]pent-4-ynoyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate
著者Muriel-Goni, S, Fabrega-Ferrer, M, Herrera-Morande, A, Coll, M.
登録日2022-05-03
公開日2022-12-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structure and inhibition of SARS-CoV-1 and SARS-CoV-2 main proteases by oral antiviral compound AG7404.
Antiviral Res., 208, 2022
3E91
DownloadVisualize
BU of 3e91 by Molmil
Crystal structure of SARS-CoV Mpro mutant in P21 at pH6.9
分子名称: 3C-like proteinase
著者Shi, J.H, Jayaraman, S, Song, J.X.
登録日2008-08-21
公開日2009-08-25
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural analysis of the activity-enhanced SARS-CoV Mpro C-terminal mutant
To be Published
3SNC
DownloadVisualize
BU of 3snc by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-NSTSQ-H (soaking)
分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, Peptide aldehyde inhibitor Ac-NSTSQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3SNE
DownloadVisualize
BU of 3sne by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (Soaking)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
3EE7
DownloadVisualize
BU of 3ee7 by Molmil
Crystal Structure of SARS-CoV nsp9 G104E
分子名称: GLYCEROL, PHOSPHATE ION, Replicase polyprotein 1a
著者Miknis, Z.J, Donaldson, E.F, Umland, T.C, Rimmer, R, Baric, R.S, Schultz, L.W.
登録日2008-09-04
公開日2009-03-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth
J.Virol., 83, 2009
3F9G
DownloadVisualize
BU of 3f9g by Molmil
Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 6.5
分子名称: 3C-like proteinase
著者Hu, T, Li, L, Jiang, H, Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
2H85
DownloadVisualize
BU of 2h85 by Molmil
Crystal Structure of Nsp 15 from SARS
分子名称: Putative orf1ab polyprotein
著者Ricagno, S, Egloff, M.P, Ulferts, R, Coutard, B, Nurizzo, D, Campanacci, V, Cambillau, C, Ziebuhr, J, Canard, B.
登録日2006-06-06
公開日2006-08-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5TL6
DownloadVisualize
BU of 5tl6 by Molmil
Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15
分子名称: Replicase polyprotein 1ab, SULFATE ION, Ubiquitin-like protein ISG15, ...
著者Dzimianski, J.V, Daczkowski, C.M, Pegan, S.D.
登録日2016-10-10
公開日2017-05-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.618 Å)
主引用文献Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species.
J. Mol. Biol., 429, 2017
3MJ5
DownloadVisualize
BU of 3mj5 by Molmil
Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation
分子名称: N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Replicase polyprotein 1a, ZINC ION
著者Mesecar, A.D, Ratia, K.M, Pegan, S.D.
登録日2010-04-12
公開日2010-06-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation
J.Med.Chem., 53, 2010
3EA7
DownloadVisualize
BU of 3ea7 by Molmil
Crystal structure of SARS-CoV main protease triple mutant STI/A in space group P21
分子名称: 3C-like proteinase
著者Shi, J.H, Jayaraman, S, Song, J.X.
登録日2008-08-25
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of SARS-CoV Mpro mutant
To be Published
3EAJ
DownloadVisualize
BU of 3eaj by Molmil
Crystal structure of SARS-CoV main protease quadruple mutant STIF/A with two molecules in one asymmetric unit
分子名称: 3C-like proteinase
著者Shi, J.H, Jayaraman, S, Song, J.X.
登録日2008-08-26
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献crystal structure of SARS-CoV Mpro mutant with two molecules one ASU
To be Published
2GA6
DownloadVisualize
BU of 2ga6 by Molmil
The crystal structure of SARS nsp10 without zinc ion as additive
分子名称: ZINC ION, orf1a polyprotein
著者Su, D, Lou, Z, Sun, F, Zhai, Y, Yang, H, Rao, Z.
登録日2006-03-08
公開日2006-08-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10
J.Virol., 80, 2006
3D62
DownloadVisualize
BU of 3d62 by Molmil
Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro
分子名称: 3C-like proteinase, benzyl (2-oxopropyl)carbamate
著者Bacha, U, Barrila, J, Gabelli, S.B, Kiso, Y, Amzel, L.M, Freire, E.
登録日2008-05-18
公開日2008-07-01
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro).
Chem.Biol.Drug Des., 72, 2008
3M3V
DownloadVisualize
BU of 3m3v by Molmil
SARS-CoV main protease triple mutant STI/A with two N-terminal additional residue (Gly-Ser)
分子名称: 3C-like proteinase
著者Shi, J.H, Song, J.X.
登録日2010-03-10
公開日2011-03-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献SARS-CoV main protease with N-terminal extension regulated by mutations on the C-terminal domain
To be Published
2D2D
DownloadVisualize
BU of 2d2d by Molmil
Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor I2
分子名称: 3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE
著者Yang, H, Bartlam, M, Xue, X, Yang, K, Liang, W, Ding, Y, Rao, Z.
登録日2005-09-08
公開日2005-09-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
1QZ8
DownloadVisualize
BU of 1qz8 by Molmil
Crystal structure of SARS coronavirus NSP9
分子名称: SULFATE ION, polyprotein 1ab
著者Egloff, M.P, Ferron, F, Campanacci, V, Longhi, S, Rancurel, C, Dutartre, H, Snijder, E.J, Gorbalenya, A.E, Cambillau, C, Canard, B.
登録日2003-09-16
公開日2004-02-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.
Proc.Natl.Acad.Sci.USA, 101, 2004
2QC2
DownloadVisualize
BU of 2qc2 by Molmil
Crystal structure of Severe Acute Respiratory Syndrome (SARS) 3C-like protease Asn214Ala mutant
分子名称: 3C-like proteinase
著者Shi, J.H.
登録日2007-06-19
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of Severe Acute Respiratory Syndrome (SARS) 3C-like protease Asn214Ala mutant with two non-native n-terminal residues (GLY AND SER)
To be Published
7FAC
DownloadVisualize
BU of 7fac by Molmil
Crystal Structure of C-terminus of the non-structural protein 2 from SARS coronavirus
分子名称: Non-structural protein 2, ZINC ION
著者Li, Y.Y, Ren, Z.L, Bao, Z.H, Ming, Z.H, Yan, L.M, Lou, Z.Y, Rao, Z.H.
登録日2021-07-06
公開日2022-08-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function.
Annu.Rev.Biochem., 91, 2022

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon