7FQB
 
 | | DHFR:NADP+:FOL complex (crystal 1, pass 5, 295 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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4NX7
 | | single cryogenic temperature model of DHFR | | 分子名称: | BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | Fenwick, R.B, van den Bedem, H, Fraser, J.S, Wright, P.E. | | 登録日 | 2013-12-08 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR.
Proc.Natl.Acad.Sci.USA, 111, 2014
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7FQ0
 | | DHFR:NADP+:FOL complex at 300 K (crystal 4) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-10 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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4KJJ
 | | Cryogenic WT DHFR | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | van den Bedem, H, Bhabha, G, Yang, K, Wright, P.E, Fraser, J.S. | | 登録日 | 2013-05-03 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
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7FQD
 | | DHFR:NADP+:FOL complex (crystal 2, pass 2, 280 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPL
 | | DHFR:NADP+:FOL complex at 280 K (crystal 1) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-09 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQE
 | | DHFR:NADP+:FOL complex (crystal 2, pass 3, 295 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ1
 | | DHFR:NADP+:FOL complex at 300 K (crystal 5) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-10 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQC
 | | DHFR:NADP+:FOL complex (crystal 2, pass 1, 295 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQG
 | | DHFR:NADP+:FOL complex (crystal 2, pass 5, 295 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5CC9
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7FQ8
 | | DHFR:NADP+:FOL complex (crystal 1, pass 2, 310 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQF
 | | DHFR:NADP+:FOL complex (crystal 2, pass 4, 310 K) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8VZ4
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7FPS
 | | DHFR:NADP+:FOL complex at 290 K (crystal 2) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-10 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ6
 | | DHFR:NADP+:FOL complex at 310 K (multi-crystal) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6CYV
 | | E. coli DHFR ternary complex with NADP and dihydrofolate | | 分子名称: | DIHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | 登録日 | 2018-04-06 | | 公開日 | 2019-01-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1, 2018
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7FQ3
 | | DHFR:NADP+:FOL complex at 310 K (crystal 1) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPZ
 | | DHFR:NADP+:FOL complex at 300 K (crystal 3) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-10 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ4
 | | DHFR:NADP+:FOL complex at 310 K (crystal 2) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6MR9
 | | E. coli DHFR complex with a reaction intermediate | | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, Dihydrofolate reductase, ... | | 著者 | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | 登録日 | 2018-10-12 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
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6MT8
 | | E. coli DHFR complex modeled with two ligand states | | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, DIHYDROFOLIC ACID, ... | | 著者 | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | 登録日 | 2018-10-19 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
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6MTH
 | | E. coli DHFR complex modeled with three ligand states | | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, DIHYDROFOLIC ACID, ... | | 著者 | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | 登録日 | 2018-10-19 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
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7FQ5
 | | DHFR:NADP+:FOL complex at 310 K (crystal 3) | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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4NX6
 | | single room temperature model of DHFR | | 分子名称: | BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | Fenwick, R.B, van den Bedem, H, Fraser, J.S, Wright, P.E. | | 登録日 | 2013-12-08 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR.
Proc.Natl.Acad.Sci.USA, 111, 2014
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