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PDB: 68 件
1PX6
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A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to asparagine
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, Glutathione S-transferase P
著者Kong, G.K.-W, Polekhina, G, McKinstry, W.J, Parker, M.W, Dragani, B, Aceto, A, Paludi, D, Principe, D.R, Mannervik, B, Stenberg, G.
登録日2003-07-02
公開日2003-07-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The multi-functional role of a highly conserved aspartic acid residue in glutathione transferase P1-1
To be Published
1EOG
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CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE
分子名称: GLUTATHIONE S-TRANSFERASE
著者Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A.
登録日2000-03-22
公開日2000-10-18
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
3KM6
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Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate
分子名称: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ...
著者Parker, L.J.
登録日2009-11-10
公開日2010-03-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.
J.Mol.Recognit., 24
1ZGN
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Crystal Structure of the Glutathione Transferase Pi in Complex with Dinitrosyl-diglutathionyl Iron Complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FE (III) ION, GLUTATHIONE, ...
著者Parker, L.J, Adams, J.J, Parker, M.W.
登録日2005-04-21
公開日2005-11-01
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
J.Biol.Chem., 280, 2005
5DAK
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Crystal Structure of human Glutathione Transferase Pi complexed with a metalloid in the absence of Glutathione
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARSENIC, Glutathione S-transferase P
著者Parker, L.J, Parker, M.W, Morton, C.J.
登録日2015-08-20
公開日2016-12-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
3PGT
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CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7,8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID, PROTEIN (GLUTATHIONE S-TRANSFERASE), ...
著者Ji, X, Xiao, B.
登録日1999-03-22
公開日1999-09-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.
Biochemistry, 38, 1999
7GSS
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Human glutathione S-transferase P1-1, complex with glutathione
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, GLUTATHIONE S-TRANSFERASE P1-1
著者Oakley, A, Parker, M.
登録日1997-08-13
公開日1998-09-16
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
10GS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE P1-1, L-gamma-glutamyl-S-benzyl-N-[(S)-carboxy(phenyl)methyl]-L-cysteinamide
著者Oakley, A, Parker, M.
登録日1997-08-14
公開日1998-09-16
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
3DD3
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Crystal Structure of the Glutathione Transferase Pi enzyme in complex with the bifunctional inhibitor, Etharapta
分子名称: (eta6-benzene)ruthenium, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, ...
著者Parker, L.J.
登録日2008-06-05
公開日2009-04-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Rational design of an organometallic glutathione transferase inhibitor
Angew.Chem.Int.Ed.Engl., 48, 2009
11GS
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Glutathione s-transferase complexed with ethacrynic acid-glutathione conjugate (form ii)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ETHACRYNIC ACID, GLUTATHIONE, ...
著者Oakley, A.J, Lo Bello, M, Mazzetti, A.P, Federici, G, Parker, M.W.
登録日1997-11-03
公開日1999-01-13
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.
FEBS Lett., 419, 1997
2J9H
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Crystal structure of human glutathione-S-transferase P1-1 cys-free mutant in complex with S-hexylglutathione at 2.4 A resolution
分子名称: GLUTATHIONE S-TRANSFERASE P, S-HEXYLGLUTATHIONE
著者Tars, K, Hegazy, U.M, Hellman, U, Mannervik, B.
登録日2006-11-08
公開日2006-11-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Modulating Catalytic Activity by Unnatural Amino Acid Residues in a Gsh-Binding Loop of Gst P1-1.
J.Mol.Biol., 376, 2008
20GS
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GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH CIBACRON BLUE
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CIBACRON BLUE, GLUTATHIONE S-TRANSFERASE
著者Oakley, A.J, Lo Bello, M, Nuccetelli, M, Mazzetti, A.P, Parker, M.W.
登録日1997-12-16
公開日1998-12-30
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
4GSS
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HUMAN GLUTATHIONE S-TRANSFERASE P1-1 Y108F MUTANT
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE
著者Oakley, A, Rossjohn, J, Parker, M.
登録日1997-01-20
公開日1998-01-28
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.
Biochemistry, 36, 1997
1EOH
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GLUTATHIONE TRANSFERASE P1-1
分子名称: GLUTATHIONE S-TRANSFERASE
著者Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A.
登録日2000-03-22
公開日2000-10-18
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
3KMO
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Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT)
分子名称: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ...
著者Parker, L.J.
登録日2009-11-11
公開日2010-03-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V
To be Published
14GS
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GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE
著者Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W.
登録日1997-11-29
公開日1999-01-13
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
1GSS
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THREE-DIMENSIONAL STRUCTURE OF CLASS PI GLUTATHIONE S-TRANSFERASE FROM HUMAN PLACENTA IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.8 ANGSTROMS RESOLUTION
分子名称: GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-hexyl-L-cysteinylglycine
著者Reinemer, P, Dirr, H.W, Ladenstein, R, Lobello, M, Federici, G, Huber, R, Parker, M.W.
登録日1992-05-28
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.
J.Mol.Biol., 227, 1992
7XBA
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Glutathione S-transferase bound with a covalent inhibitor
分子名称: 3-[3-[[2-[5-[(3,5-dimethyl-4-nitro-pyrazol-1-yl)methyl]furan-2-yl]-5-(methylcarbamoyl)benzimidazol-1-yl]methyl]azetidin-1-yl]sulfonylbenzenesulfonic acid, GLUTATHIONE, Glutathione S-transferase P
著者Jiang, L.L, Zhou, L.
登録日2022-03-21
公開日2023-09-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Glutathione S-transferase bound with a covalent inhibitor
To Be Published
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