7K4K
| Human Arginase 1 in complex with compound 52. | 分子名称: | 3-[(3~{a}~{S},4~{S},6~{a}~{R})-4-carboxy-2,3,4,5,6,6~{a}-hexahydro-1~{H}-pyrrolo[2,3-c]pyrrol-3~{a}-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, MANGANESE (II) ION | 著者 | Palte, R.L. | 登録日 | 2020-09-15 | 公開日 | 2021-12-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7KLM
| Human Arginase1 Complexed with Inhibitor Compound 24a | 分子名称: | 3-[(2~{S},3~{R},4~{R})-4-[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, MANGANESE (II) ION | 著者 | Palte, R.L. | 登録日 | 2020-10-30 | 公開日 | 2021-09-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. Acs Med.Chem.Lett., 12, 2021
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1WVB
| Crystal structure of human arginase I: the mutant E256Q | 分子名称: | Arginase 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE | 著者 | Di Costanzo, L, Guadalupe, S, Mora, A, Centeno, F, Christianson, D.W. | 登録日 | 2004-12-14 | 公開日 | 2005-09-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of human arginase I: the mutant E256Q To be Published
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8E5N
| Structure of ARG1 complex with pyrrolidine-based non-boronic acid inhibitor 10 | 分子名称: | 1-{[(3S,4S)-3-(3-fluorophenyl)-4-{[4-(1,3,4-triethyl-1H-pyrazol-5-yl)piperidin-1-yl]methyl}pyrrolidin-1-yl]methyl}cyclopentane-1-carboxylic acid, Arginase-1, MANGANESE (II) ION | 著者 | Palte, R.L, Gathiaka, S. | 登録日 | 2022-08-22 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.538 Å) | 主引用文献 | Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods. Bioorg.Med.Chem.Lett., 84, 2023
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7LEY
| Trimeric human Arginase 1 in complex with mAb5 | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb5 heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7LEX
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7LF0
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7LF2
| Trimeric human Arginase 1 in complex with mAb4 | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb4 monoclonal antibody heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7LF1
| Trimeric human Arginase 1 in complex with mAb3 | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb3 heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7LEZ
| Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb1 heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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