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PDB: 39 件
5CFA
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Crystal structures of Bbp from Staphylococcus aureus with peptide ligand
分子名称: Bone sialoprotein-binding protein, MAGNESIUM ION, Peptide from Fibrinogen alpha chain
著者Yu, Y, Zhang, X.Y, Gu, J.K.
登録日2015-07-08
公開日2015-09-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen alpha
Protein Cell, 6, 2015
4F27
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Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB
分子名称: Clumping factor B, MAGNESIUM ION, peptide from Fibrinogen alpha chain
著者Yang, M.J, Xiang, H, Wang, J.W, Liu, B, Chen, Y.G, Liu, L, Deng, X.M, Feng, Y.
登録日2012-05-07
公開日2012-08-08
最終更新日2015-02-04
実験手法X-RAY DIFFRACTION (1.917 Å)
主引用文献Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB
Plos Pathog., 8, 2012
1FZD
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STRUCTURE OF RECOMBINANT ALPHAEC DOMAIN FROM HUMAN FIBRINOGEN-420
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Spraggon, G, Applegate, D, Everse, S.J, Zhang, J.-Z, Veerapandian, L, Redman, C, Doolittle, R.F, Grieninger, G.
登録日1998-06-22
公開日1998-08-19
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.
Proc.Natl.Acad.Sci.USA, 95, 1998
1BBR
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THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION
分子名称: EPSILON-THROMBIN, FIBRINOGEN ALPHA/ALPHA-E CHAIN PRECURSOR
著者Martin, P, Edwards, B.
登録日1992-04-27
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
J.Biol.Chem., 267, 1992
3E1I
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Crystal Structure of BbetaD432A Variant Fibrinogen Fragment D with the Peptide Ligand Gly-His-Arg-Pro-amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha chain, ...
著者Bowley, S.R, Lord, S.T.
登録日2008-08-04
公開日2009-01-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Fibrinogen variant BbetaD432A has normal polymerization but does not bind knob "B".
Blood, 113, 2009
1FZC
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CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Everse, S.J, Spraggon, G, Veerapandian, L, Riley, M, Doolittle, R.F.
登録日1998-05-19
公開日1998-10-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of fragment double-D from human fibrin with two different bound ligands.
Biochemistry, 37, 1998
2OYH
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Crystal Structure of Fragment D of gammaD298,301A Fibrinogen with the Peptide Ligand Gly-His-Arg-Pro-Amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha chain, ...
著者Kostelansky, M.S, Gorkun, O.V, Lord, S.T.
登録日2007-02-22
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Probing the gamma2 Calcium-Binding Site: Studies with gammaD298,301A Fibrinogen Reveal Changes in the gamma294-301 Loop that Alter the Integrity of the "a" Polymerization Site.
Biochemistry, 46, 2007
1RE3
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BU of 1re3 by Molmil
Crystal Structure of Fragment D of BbetaD398A Fibrinogen with the Peptide Ligand Gly-His-Arg-Pro-Amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha/alpha-E chain, ...
著者Kostelansky, M.S, Betts, L, Gorkun, O.V, Lord, S.T.
登録日2003-11-06
公開日2004-05-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献BbetaGlu397 and BbetaAsp398 but not BbetaAsp432 are required for "B:b" interactions.
Biochemistry, 43, 2004
1FZG
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CRYSTAL STRUCTURE OF FRAGMENT D FROM HUMAN FIBRINOGEN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN
著者Everse, S.J, Spraggon, G, Veerapandian, L, Doolittle, R.F.
登録日1999-01-01
公開日1999-06-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
Biochemistry, 38, 1999
1DM4
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BU of 1dm4 by Molmil
SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)
分子名称: PROTEIN (ALPHA THROMBIN:LIGHT CHAIN), PROTEIN (FIBRINOPEPTIDE), PROTEIN (MUTANT ALPHA THROMBIN:HEAVY CHAIN)
著者Krishnan, R, Sadler, E.J, Tulinsky, A.
登録日1999-12-13
公開日2000-01-19
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity.
Acta Crystallogr.,Sect.D, 56, 2000
1YCP
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BU of 1ycp by Molmil
THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
分子名称: ALPHA THROMBIN, EPSILON THROMBIN, FIBRINOPEPTIDE A-ALPHA
著者Malkowski, M.G, Edwards, B.F.P.
登録日1997-05-01
公開日1998-05-06
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Biochem.J., 326, 1997
3AT0
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BU of 3at0 by Molmil
Structural and biochemical characterization of ClfB:ligand interactions
分子名称: C-terminal alpha chain peptide, Clumping factor B
著者Ganesh, V.K.
登録日2010-12-23
公開日2011-05-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and biochemical characterization of ClfB:ligand interactions
To be published
1FPH
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THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), FIBRINOPEPTIDE A, ...
著者Stubbs, M.T, Bode, W.
登録日1993-04-21
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The interaction of thrombin with fibrinogen. A structural basis for its specificity.
Eur.J.Biochem., 206, 1992
1RF1
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BU of 1rf1 by Molmil
Crystal Structure of Fragment D of gammaE132A Fibrinogen with the Peptide Ligand Gly-His-Arg-Pro-amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha/alpha-E chain, ...
著者Kostelansky, M.S, Gorkun, O.V, Lord, S.T.
登録日2003-11-07
公開日2004-03-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Calcium-Binding Site beta2, Adjacent to the "b" Polymerization Site, Modulates Lateral Aggregation of Protofibrils during Fibrin Polymerization.
Biochemistry, 43, 2004
2HLO
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BU of 2hlo by Molmil
Crystal Structure of Fragment D-dimer from Human Fibrin Complexed with Gly-hydroxyPro-Arg-Pro-amide
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Doolittle, R.F, Kollman, J.M, Chen, A, Pandi, L.
登録日2006-07-08
公開日2007-07-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献

3BVH
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Crystal Structure of Recombinant gammaD364A Fibrinogen Fragment D with the Peptide Ligand Gly-Pro-Arg-Pro-Amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-mer peptide GPRP, CALCIUM ION, ...
著者Bowley, S.R, Merenbloom, B.K, Betts, L, Okumura, N, Heroux, A, Gorkun, O.V, Lord, S.T.
登録日2008-01-07
公開日2008-09-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic.
Biochemistry, 47, 2008
1FZF
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CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN
著者Everse, S.J, Spraggon, G, Veerapandian, L, Doolittle, R.F.
登録日1998-12-28
公開日1999-06-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
Biochemistry, 38, 1999
1RE4
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BU of 1re4 by Molmil
Crystal Structure of Fragment D of BbetaD398A Fibrinogen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha/alpha-E chain, ...
著者Kostelansky, M.S, Betts, L, Gorkun, O.V, Lord, S.T.
登録日2003-11-06
公開日2004-05-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献BbetaGlu397 and BbetaAsp398 but not BbetaAsp432 are required for "B:b" interactions.
Biochemistry, 43, 2004
2Z4E
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Crystal Structure of D-Dimer from Human Fibrin Complexed with Gly-His-Arg-Pro-Tyr-amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Doolittle, R.F, Pandi, L.
登録日2007-06-16
公開日2007-10-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini
Biochemistry, 46, 2007
2H43
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Crystal Structure of Human Fragment D Complexed with Ala-His-Arg-Pro-amide
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Doolittle, R.F, Pandi, L.
登録日2006-05-23
公開日2006-12-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Differences in Binding Specificity for the Homologous gamma- and beta-Chain "Holes" on Fibrinogen: Exclusive Binding of Ala-His-Arg-Pro-amide by the beta-Chain Hole.
Biochemistry, 45, 2006
2OYI
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Crystal Structure of Fragment D of gammaD298,301A Fibrinogen with the Peptide Ligand Gly-Pro-Arg-Pro-Amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha chain, ...
著者Kostelansky, M.S, Gorkun, O.V, Lord, S.T.
登録日2007-02-22
公開日2007-05-15
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Probing the gamma2 Calcium-Binding Site: Studies with gammaD298,301A Fibrinogen Reveal Changes in the gamma294-301 Loop that Alter the Integrity of the "a" Polymerization Site.
Biochemistry, 46, 2007
1LT9
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BU of 1lt9 by Molmil
Crystal Structure of Recombinant Human Fibrinogen Fragment D
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha/alpha-E chain, ...
著者Kostelansky, M.S, Betts, L, Gorkun, O.V, Lord, S.T.
登録日2002-05-20
公開日2002-11-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献2.8 A Crystal Structures of Recombinant Fibrinogen Fragment D with and without Two Peptide Ligands: GHRP Binding to the "b" Site Disrupts Its Nearby Calcium-binding Site.
Biochemistry, 41, 2002
1LTJ
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Crystal Structure of Recombinant Human Fibrinogen Fragment D with the Peptide Ligands Gly-Pro-Arg-Pro-Amide and Gly-His-Arg-Pro-Amide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen Beta chain, ...
著者Kostelansky, M.S, Betts, L, Gorkun, O.V, Lord, S.T.
登録日2002-05-20
公開日2002-11-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献2.8 A Crystal Structures of Recombinant Fibrinogen Fragment D with and without Two Peptide Ligands: GHRP Binding to the "b" Site Disrupts Its Nearby Calcium-binding Site.
Biochemistry, 41, 2002
2Q9I
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Crystal Structure of D-Dimer from Human Fibrin Complexed with Met-His-Arg-Pro-Tyr-amide.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrin B Knob (GHRPam), ...
著者Doolittle, R.F, Pandi, L.
登録日2007-06-12
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini
Biochemistry, 46, 2007
1RF0
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Crystal Structure of Fragment D of gammaE132A Fibrinogen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fibrinogen alpha/alpha-E chain, ...
著者Kostelansky, M.S, Gorkun, O.V, Lord, S.T.
登録日2003-11-07
公開日2004-03-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Calcium-Binding Site beta2, Adjacent to the "b" Polymerization Site, Modulates Lateral Aggregation of Protofibrils during Fibrin Polymerization.
Biochemistry, 43, 2004

 

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