2A65
 
 | | Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters | | 分子名称: | CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ... | | 著者 | Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E. | | 登録日 | 2005-07-01 | | 公開日 | 2005-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
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2Q72
 | | Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine | | 分子名称: | 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | | 著者 | Singh, S.K, Yamashita, A, Gouaux, E. | | 登録日 | 2007-06-05 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
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3F3E
 | | Crystal structure of LeuT bound to L-leucine (30 mM) and sodium | | 分子名称: | LEUCINE, SODIUM ION, Transporter, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-30 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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2Q6H
 | | Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine | | 分子名称: | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | | 著者 | Singh, S.K, Yamashita, A, Gouaux, E. | | 登録日 | 2007-06-05 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
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2QEI
 | | Crystal structure analysis of LeuT complexed with L-alanine, sodium, and clomipramine | | 分子名称: | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, ALANINE, SODIUM ION, ... | | 著者 | Singh, S.K, Yamashita, A, Gouaux, E. | | 登録日 | 2007-06-25 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
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3F48
 | | Crystal structure of LeuT bound to L-alanine and sodium | | 分子名称: | ALANINE, SODIUM ION, Transporter, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-31 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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2QB4
 | | Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine | | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | | 著者 | Singh, S.K, Yamashita, A, Gouaux, E. | | 登録日 | 2007-06-15 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
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3F4I
 | | Crystal Structure of LeuT bound to L-selenomethionine and sodium | | 分子名称: | SELENOMETHIONINE, SODIUM ION, Transporter, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-31 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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3GJD
 | | Crystal Structure of LeuT with bound OG | | 分子名称: | CHLORIDE ION, LEUCINE, SODIUM ION, ... | | 著者 | Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P. | | 登録日 | 2009-03-08 | | 公開日 | 2009-04-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
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3F3A
 | | Crystal Structure of LeuT bound to L-Tryptophan and Sodium | | 分子名称: | SODIUM ION, TETRADECANE, TRYPTOPHAN, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-30 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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7LQK
 | | Crystal structure of the R375A mutant of LeuT | | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | | 登録日 | 2021-02-13 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
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3F3C
 | | Crystal structure of LeuT bound to 4-Fluoro-L-Phenylalanine and sodium | | 分子名称: | 4-FLUORO-L-PHENYLALANINE, SODIUM ION, Transporter, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-30 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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3USP
 | | Crystal structure of LeuT in heptyl-beta-D-Selenoglucoside | | 分子名称: | CHLORIDE ION, LEUCINE, SODIUM ION, ... | | 著者 | Wang, H, Elferich, J, Gouaux, E. | | 登録日 | 2011-11-23 | | 公開日 | 2012-01-11 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.
Nat.Struct.Mol.Biol., 19, 2012
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3GWU
 | | Leucine transporter LeuT in complex with sertraline | | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ... | | 著者 | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | | 登録日 | 2009-04-01 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
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7LQJ
 | | Crystal structure of LeuT bound to L-Alanine | | 分子名称: | ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Font, J, Aguilar, J, Galli, A, Ryan, R. | | 登録日 | 2021-02-13 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.144 Å) | | 主引用文献 | Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
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3F4J
 | | Crystal structure of LeuT bound to glycine and sodium | | 分子名称: | GLYCINE, SODIUM ION, Transporter, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-31 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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4MMB
 | | Crystal structure of LeuBAT (delta6 mutant) in complex with sertraline | | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter, ... | | 著者 | Wang, H, Gouaux, E. | | 登録日 | 2013-09-08 | | 公開日 | 2013-10-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
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3MPQ
 | | I204R1 mutant of LeuT | | 分子名称: | CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ... | | 著者 | Kroncke, B.M. | | 登録日 | 2010-04-27 | | 公開日 | 2010-12-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
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3MPN
 | | F177R1 mutant of LeuT | | 分子名称: | CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ... | | 著者 | Kroncke, B.M. | | 登録日 | 2010-04-27 | | 公開日 | 2010-12-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
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3F3D
 | | Crystal structure of LeuT bound to L-Methionine and sodium | | 分子名称: | METHIONINE, SODIUM ION, Transporter, ... | | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | 登録日 | 2008-10-30 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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4MMC
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4MMD
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3GWV
 | | Leucine transporter LeuT in complex with R-fluoxetine | | 分子名称: | (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | | 著者 | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | | 登録日 | 2009-04-01 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
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7DJ2
 | | Crystal structure of the G26C/E290S mutant of LeuT | | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | 登録日 | 2020-11-19 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DII
 | | Crystal structure of LeuT in lipidic cubic phase at pH 7 | | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | 登録日 | 2020-11-19 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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