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PDB: 16 件
8SC1
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BU of 8sc1 by Molmil
Human OCT1 (Apo) in inward-open conformation
分子名称: Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8JU0
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BU of 8ju0 by Molmil
hOCT1 in complex with spironolactone in inward facing occluded conformation
分子名称: SPIRONOLACTONE, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-23
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8SC6
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BU of 8sc6 by Molmil
Human OCT1 bound to thiamine in inward-open conformation
分子名称: 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8JTW
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hOCT1 in complex with nb5660 in inward facing partially open 1 conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8SC3
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BU of 8sc3 by Molmil
Human OCT1 bound to fenoterol in inward-open conformation
分子名称: Fenoterol, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8JTY
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BU of 8jty by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 2 conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTZ
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BU of 8jtz by Molmil
hOCT1 in complex with spironolactone in outward facing partially occluded conformation
分子名称: SPIRONOLACTONE, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTX
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BU of 8jtx by Molmil
hOCT1 in complex with nb5660 in inward facing fully open conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8SC2
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BU of 8sc2 by Molmil
Human OCT1 bound to diltiazem in inward-open conformation
分子名称: Diltiazem, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8ET8
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BU of 8et8 by Molmil
Cryo-EM structure of the organic cation transporter 1 in complex with verapamil
分子名称: (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8SC4
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BU of 8sc4 by Molmil
Human OCT1 bound to metformin in inward-open conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8ET6
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BU of 8et6 by Molmil
Cryo-EM structure of the organic cation transporter 1 in the apo state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET7
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BU of 8et7 by Molmil
Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1
著者Suo, Y, Wright, N.J, Lee, S.-Y.
登録日2022-10-16
公開日2023-05-31
最終更新日2023-08-02
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8JTV
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BU of 8jtv by Molmil
hOCT1 in complex with metformin in inward occluded conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTT
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BU of 8jtt by Molmil
hOCT1 in complex with metformin in outward occluded conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTS
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BU of 8jts by Molmil
hOCT1 in complex with metformin in outward open conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024

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件を2024-07-10に公開中

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