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PDB: 15 件
6SZU
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BU of 6szu by Molmil
Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence
分子名称: 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-02
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
5M3H
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BU of 5m3h by Molmil
Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Lukarska, M, Pflug, A, Cusack, S.
登録日2016-10-14
公開日2016-12-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Nature, 541, 2017
6SZV
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BU of 6szv by Molmil
Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only)
分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-02
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T0N
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BU of 6t0n by Molmil
Bat Influenza A polymerase pre-initiation complex
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
4WSB
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BU of 4wsb by Molmil
Bat Influenza A polymerase with bound vRNA promoter
分子名称: Influenza A polymerase vRNA promoter 3' end, Influenza A polymerase vRNA promoter 5' end, PHOSPHATE ION, ...
著者Cusack, S, Pflug, A, Guilligay, D, Reich, S.
登録日2014-10-26
公開日2014-11-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature, 516, 2014
6FHH
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BU of 6fhh by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Lukarska, M, Cusack, S.
登録日2018-01-14
公開日2019-01-30
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published
6TW1
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BU of 6tw1 by Molmil
Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence
分子名称: 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2020-01-11
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 2020
6FHI
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BU of 6fhi by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Lukarska, M, Cusack, S.
登録日2018-01-14
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published
6T0R
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BU of 6t0r by Molmil
Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with mutated oligo(U) sequence
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6EVK
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BU of 6evk by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ...
著者Pflug, A, Cusack, S.
登録日2017-11-01
公開日2017-12-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6T0V
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BU of 6t0v by Molmil
Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase)
分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T0S
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BU of 6t0s by Molmil
Bat Influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence
分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T0U
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BU of 6t0u by Molmil
Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T2C
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BU of 6t2c by Molmil
Bat Influenza A polymerase recycling complex
分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-08
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6EVJ
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BU of 6evj by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(GDM))-R(P*AP*AP*U)-3'), ...
著者Pflug, A, Cusack, S.
登録日2017-11-01
公開日2017-12-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018

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件を2024-07-17に公開中

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