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PDB: 105 件
6NIX
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Crystal structure of Immune Receptor
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, ...
著者Ting, Y.T, Reid, H.H, Rossjohn, J.
登録日2019-01-01
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Immune Receptor
To Be Published
5V4M
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Structure of HLA-DR15 with bound alpha3(135-145) peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, ...
著者Petersen, J, Rossjohn, J.
登録日2017-03-10
公開日2017-05-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
1PYW
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Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
分子名称: 9-residue influenza virus hemagglutinin related peptide FVKQNA(MAA)AL, Enterotoxin type C-3, HLA class II histocompatibility antigen, ...
著者Zavala-Ruiz, Z, Sundberg, E.J, Stone, J.D, DeOliveira, D.B, Chan, I.C, Svendsen, J, Mariuzza, R.A, Stern, L.J.
登録日2003-07-09
公開日2003-12-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Exploration of the P6/P7 region of the peptide-binding site of the human class II Major Histocompatability Complex Protein HLA-DR1
J.Biol.Chem., 278, 2003
4I5B
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Structure of human MHC class II protein HLA-DR1 carrying an influenza hemagglutinin peptide partially filling the binding groove
分子名称: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
著者Schulze, M.-S.E.D.
登録日2012-11-28
公開日2013-12-04
最終更新日2015-04-15
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Disruption of hydrogen bonds between major histocompatibility complex class II and the peptide N-terminus is not sufficient to form a human leukocyte antigen-DM receptive state of major histocompatibility complex class II.
Plos One, 8, 2013
4MD0
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Immune Receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Citrullinated Vimentin, ...
著者Scally, S.W, Rossjohn, J.
登録日2013-08-22
公開日2013-12-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.194 Å)
主引用文献A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.
J.Exp.Med., 210, 2013
4OV5
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Structure of HLA-DR1 with a bound peptide with non-optimal alanine in the P1 pocket
分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, HLA class II histocompatibility antigen, ...
著者Trenh, P, Yin, L, Stern, L.J.
登録日2014-02-20
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide.
J.Biol.Chem., 289, 2014
6BIX
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HLA-DRB1 in complex with citrullinated LL37 peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II DR-beta (HLA-DR B), HLA class II histocompatibility antigen, ...
著者Ting, Y.T, Scally, S.W, Rossjohn, J.
登録日2017-11-03
公開日2018-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
J. Biol. Chem., 293, 2018
4AEN
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HLA-DR1 with covalently linked CLIP106-120 in reversed orientation
分子名称: GLYCEROL, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ...
著者Schlundt, A, Guenther, S, Sticht, J, Wieczorek, M, Roske, Y, Heinemann, U, Freund, C.
登録日2012-01-11
公開日2012-08-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex.
J.Mol.Biol., 423, 2012
1SJH
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HLA-DR1 complexed with a 13 residue HIV capsid peptide
分子名称: Enterotoxin type C-3, GAG polyprotein, HLA class II histocompatibility antigen, ...
著者Zavala-Ruiz, Z, Strug, I, Walker, B.D, Norris, P.J, Stern, L.J.
登録日2004-03-03
公開日2004-08-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proc.Natl.Acad.Sci.Usa, 101, 2004
6V1A
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immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 74cit69-81, GLYCEROL, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-20
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
2IPK
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Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
分子名称: Enterotoxin type C-3, HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine), ...
著者Nguyen, T.T, Stern, L.J.
登録日2006-10-12
公開日2007-03-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Nat.Chem.Biol., 3, 2007
4MCY
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Immune Receptor
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Citrullinated Vimentin, ...
著者Scally, S.W, Rossjohn, J.
登録日2013-08-22
公開日2013-11-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.
J.Exp.Med., 210, 2013
1JWU
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BU of 1jwu by Molmil
Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2
分子名称: Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ...
著者Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A.
登録日2001-09-05
公開日2003-07-08
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation
Structure, 11, 2003
6BIR
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BU of 6bir by Molmil
HLA-DRB1 in complex with citrullinated Vimentin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ...
著者Ting, Y.T, Scally, S.W, Rossjohn, J.
登録日2017-11-02
公開日2018-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
J. Biol. Chem., 293, 2018
2XN9
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BU of 2xn9 by Molmil
Crystal structure of the ternary complex between human T cell receptor, staphylococcal enterotoxin H and human major histocompatibility complex class II
分子名称: ENTEROTOXIN H, GLYCEROL, HEMAGGLUTININ, ...
著者Saline, M, Rodstrom, K.E.J, Fischer, G, Orekhov, V.Y, Karlsson, B.G, Lindkvist-Petersson, K.
登録日2010-07-31
公開日2010-11-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Structure of Superantigen Complexed with Tcr and Mhc Reveals Novel Insights Into Superantigenic T Cell Activation.
Nat.Commun., 1, 2010
3QXD
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BU of 3qxd by Molmil
F54C HLA-DR1 bound with CLIP peptide
分子名称: HLA class II histocompatibility antigen gamma chain peptide, HLA class II histocompatibility antigen, DR alpha chain, ...
著者Painter, C.A, Stern, L.J.
登録日2011-03-01
公開日2011-11-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.302 Å)
主引用文献Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
Proc.Natl.Acad.Sci.USA, 108, 2011
6V18
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immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta, GLYCEROL, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-20
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
4AH2
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HLA-DR1 with covalently linked CLIP106-120 in canonical orientation
分子名称: GLYCEROL, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN,DRB1-1 BETA CHAIN, ...
著者Schlundt, A, Guenther, S, Sticht, J, Wieczorek, M, Roske, Y, Heinemann, U, Freund, C.
登録日2012-02-03
公開日2012-08-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex.
J.Mol.Biol., 423, 2012
1J8H
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Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ HA1 PEPTIDE CHAIN, ...
著者Hennecke, J, Wiley, D.C.
登録日2001-05-21
公開日2002-03-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
J.Exp.Med., 195, 2002
3S4S
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BU of 3s4s by Molmil
Crystal structure of CD4 mutant bound to HLA-DR1
分子名称: GLYCEROL, HLA class II histocompatibility antigen, DR alpha chain, ...
著者Li, Y.
登録日2011-05-20
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
1KLG
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BU of 1klg by Molmil
Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
分子名称: ENTEROTOXIN TYPE C-3, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, ...
著者Sundberg, E.J, Sawicki, M.W, Andersen, P.S, Sidney, J, Sette, A, Mariuzza, R.A.
登録日2001-12-11
公開日2002-08-02
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.
J.Mol.Biol., 319, 2002
6BIL
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BU of 6bil by Molmil
HLA-DRB1 in complex with citrullinated fibrinogen peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 74cit69-81, HLA class II histocompatibility antigen, ...
著者Ting, Y.T, Scally, S.W, Rossjohn, J.
登録日2017-11-02
公開日2018-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
J. Biol. Chem., 293, 2018
6CQL
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Crystal structure of F24 TCR -DR11-RQ13 peptide complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, F24 alpha chain, F24 beta Chain, ...
著者Farenc, C, Gras, S, Rossjohn, J.
登録日2018-03-15
公開日2018-06-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献CD4+T cell-mediated HLA class II cross-restriction in HIV controllers.
Sci Immunol, 3, 2018
6CPO
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Crystal structure of DR15 presenting the RQ13 peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ...
著者Farenc, C, Gras, S, Rossjohn, J.
登録日2018-03-13
公開日2018-06-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献CD4+T cell-mediated HLA class II cross-restriction in HIV controllers.
Sci Immunol, 3, 2018
1T5W
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HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)
分子名称: 15-mer peptide fragment of Regulatory protein MIG1, HLA class II histocompatibility antigen, DR alpha chain, ...
著者Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J.
登録日2004-05-05
公開日2004-08-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004

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