6BIR

HLA-DRB1 in complex with citrullinated Vimentin peptide

Summary for 6BIR

• Entry DOI: 10.2210/pdb6bir/pdb
• Related: 6BIJ 6BIL 6BIN
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen, Vimentin 424Cit419-431, ... (5 entities in total)
• Functional Keywords: hla, mhc, citrulline, rheumatoid arthritis, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 47049.19

Authors

Ting, Y.T.,Scally, S.W.,Rossjohn, J. (deposition date: 2017-11-02, release date: 2018-01-17, Last modification date: 2023-11-15)

• Primary citation: Ting, Y.T.,Petersen, J.,Ramarathinam, S.H.,Scally, S.W.,Loh, K.L.,Thomas, R.,Suri, A.,Baker, D.G.,Purcell, A.W.,Reid, H.H.,Rossjohn, J.; The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.; J. Biol. Chem., 293:3236-3251, 2018; PubMed: 29317506; DOI: 10.1074/jbc.RA117.001013

Experimental method

X-RAY DIFFRACTION (2.3 Å)