6CW8
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![BU of 6cw8 by Molmil](/molmil-images/mine/6cw8) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with RTS-V5 | 分子名称: | 1,2-ETHANEDIOL, Hdac6 protein, N-(2,2-dimethylpropyl)-N~2~-[4-(hydroxycarbamoyl)benzene-1-carbonyl]-L-asparaginyl-N-benzyl-L-alaninamide, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2018-03-30 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J. Med. Chem., 61, 2018
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6WYQ
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![BU of 6wyq by Molmil](/molmil-images/mine/6wyq) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with 4-iodo-SAHA | 分子名称: | Histone deacetylase 6, N~1~-hydroxy-N~8~-(4-iodophenyl)octanediamide, POTASSIUM ION, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2020-05-13 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.90001464 Å) | 主引用文献 | Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallogr.,Sect.F, 76, 2020
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6VNR
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![BU of 6vnr by Molmil](/molmil-images/mine/6vnr) | Crystal Structure of Danio rerio Histone Deacetylase 6 Catalytic Domain 2 (CD2) Complexed with Bishydroxamic Acid Inhibitor | 分子名称: | 1,2-ETHANEDIOL, Hdac6 protein, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, ... | 著者 | Osko, J.D, Porter, N.J, Christianson, D.W. | 登録日 | 2020-01-29 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.94301319 Å) | 主引用文献 | Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem, 15, 2020
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6DVO
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![BU of 6dvo by Molmil](/molmil-images/mine/6dvo) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with Bavarostat | 分子名称: | 1,2-ETHANEDIOL, 3-fluoro-N-hydroxy-4-[(methyl{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)methyl]benzamide, Hdac6 protein, ... | 著者 | Porter, N.J, Christianson, D.W. | 登録日 | 2018-06-24 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J. Med. Chem., 61, 2018
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5G0I
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![BU of 5g0i by Molmil](/molmil-images/mine/5g0i) | Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker cleaved) in complex with Nexturastat A | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, HDAC6, ... | 著者 | Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. | 登録日 | 2016-03-18 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
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8GD4
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![BU of 8gd4 by Molmil](/molmil-images/mine/8gd4) | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6 | 分子名称: | 2-(benzylamino)-N'-(difluoroacetyl)pyrimidine-5-carbohydrazide, Hdac6 protein, POTASSIUM ION, ... | 著者 | Watson, P.R, Craigin, A.D, Christianson, D.W. | 登録日 | 2023-03-03 | 公開日 | 2023-10-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 . J.Med.Chem., 66, 2023
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8EQI
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![BU of 8eqi by Molmil](/molmil-images/mine/8eqi) | |
5EEM
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![BU of 5eem by Molmil](/molmil-images/mine/5eem) | |
6CSQ
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![BU of 6csq by Molmil](/molmil-images/mine/6csq) | |
6V79
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![BU of 6v79 by Molmil](/molmil-images/mine/6v79) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2376 | 分子名称: | 1,2-ETHANEDIOL, 4-{[(2S)-3,3-dimethyl-2-(pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]methyl}-N-hydroxybenzamide, Hdac6 protein, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2019-12-08 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.03951526 Å) | 主引用文献 | Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. J.Med.Chem., 64, 2021
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6V7A
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![BU of 6v7a by Molmil](/molmil-images/mine/6v7a) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2657 | 分子名称: | Hdac6 protein, N-hydroxy-4-[(1-methyl-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)methyl]benzamide, POTASSIUM ION, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2019-12-08 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.0874176 Å) | 主引用文献 | Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation. Acs Med.Chem.Lett., 11, 2020
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6DVL
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![BU of 6dvl by Molmil](/molmil-images/mine/6dvl) | |
5EEF
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![BU of 5eef by Molmil](/molmil-images/mine/5eef) | |
5EFH
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![BU of 5efh by Molmil](/molmil-images/mine/5efh) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue | 分子名称: | 1,2-ETHANEDIOL, 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, BROMIDE ION, ... | 著者 | Hai, Y, Christianson, D.W. | 登録日 | 2015-10-23 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.162 Å) | 主引用文献 | Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
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6DVN
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![BU of 6dvn by Molmil](/molmil-images/mine/6dvn) | |
5EFG
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![BU of 5efg by Molmil](/molmil-images/mine/5efg) | |
7O2R
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![BU of 7o2r by Molmil](/molmil-images/mine/7o2r) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3985 | 分子名称: | 3,5-bis(fluoranyl)-~{N}-oxidanyl-4-[(5-pyrimidin-2-yl-1,2,3,4-tetrazol-2-yl)methyl]benzamide, DI(HYDROXYETHYL)ETHER, Histone deacetylase 6, ... | 著者 | Zrubek, K, Sandrone, G, Cukier, C.D, Stevenazzi, A. | 登録日 | 2021-03-31 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. Acs Med.Chem.Lett., 12, 2021
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6PZR
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![BU of 6pzr by Molmil](/molmil-images/mine/6pzr) | |
6WYO
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![BU of 6wyo by Molmil](/molmil-images/mine/6wyo) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) H82F F202Y double mutant complexed with Trichostatin A | 分子名称: | Histone deacetylase 6, POTASSIUM ION, TRICHOSTATIN A, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2020-05-13 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.30000281 Å) | 主引用文献 | Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallogr.,Sect.F, 76, 2020
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7QNO
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![BU of 7qno by Molmil](/molmil-images/mine/7qno) | Crystal structure of ligand-free Danio rerio HDAC6 CD1 CD2 | 分子名称: | GLYCEROL, Histone deacetylase 6, POTASSIUM ION, ... | 著者 | Kempf, G, Langousis, G, Sanchez, J, Matthias, P. | 登録日 | 2021-12-21 | 公開日 | 2022-02-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Expression and Crystallization of HDAC6 Tandem Catalytic Domains. Methods Mol.Biol., 2589, 2023
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8TQ0
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6WYP
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![BU of 6wyp by Molmil](/molmil-images/mine/6wyp) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with SAHA-BPyne | 分子名称: | Histone deacetylase 6, N~1~-(4-{4-[(hex-5-ynoyl)amino]benzene-1-carbonyl}phenyl)-N~8~-hydroxyoctanediamide, POTASSIUM ION, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2020-05-13 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.40006351 Å) | 主引用文献 | Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallogr.,Sect.F, 76, 2020
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6CGP
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![BU of 6cgp by Molmil](/molmil-images/mine/6cgp) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with MAIP-032 | 分子名称: | 1,2-ETHANEDIOL, Hdac6 protein, N-hydroxy-4-[(2-propylimidazo[1,2-a]pyridin-3-yl)amino]benzamide, ... | 著者 | Osko, J.D, Christianson, D.W. | 登録日 | 2018-02-20 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors. Org. Lett., 20, 2018
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5EFB
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![BU of 5efb by Molmil](/molmil-images/mine/5efb) | |
5EF8
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![BU of 5ef8 by Molmil](/molmil-images/mine/5ef8) | |