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PDB: 24 件
3ORK
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Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 2)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者Echols, N, Lombana, T.N, Thomsen, N.D, Ng, H.-L, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB
Structure, 18, 2010
3F61
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Crystal Structure of M. tuberculosis PknB Leu33Asp/Val222Asp double mutant in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase pknB
著者Mieczkowski, C.A, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2008-11-05
公開日2008-12-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.
Embo J., 27, 2008
5E10
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BU of 5e10 by Molmil
Crystal Structure of PASTA Domains 1 and 2 of Mycobacterium tuberculosis Protein Kinase B
分子名称: Serine/threonine-protein kinase PknB
著者Prigozhin, D.M, TB Structural Genomics Consortium (TBSGC)
登録日2015-09-29
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
3ORO
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BU of 3oro by Molmil
Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 4)
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine protein kinase
著者Good, M.C, Echols, N, Lombana, T.N, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
Structure, 18, 2010
3ORT
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BU of 3ort by Molmil
Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 6)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine protein kinase
著者Good, M.C, Echols, N, Lombana, T.N, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB
Structure, 18, 2010
5E0Z
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BU of 5e0z by Molmil
Crystal Structure of PASTA Domains 3 and 4 of Mycobacterium tuberculosis Protein Kinase B
分子名称: Serine/threonine-protein kinase PknB
著者Prigozhin, D.M, TB Structural Genomics Consortium (TBSGC)
登録日2015-09-29
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
3ORI
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BU of 3ori by Molmil
Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 1)
分子名称: MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine protein kinase
著者Lombana, T.N, Echols, N, Good, M.C, Thomsen, N.D, Ng, H.-L, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
Structure, 18, 2010
5E0Y
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BU of 5e0y by Molmil
Crystal Structure of PASTA Domain 4 of Mycobacterium tuberculosis Protein Kinase B
分子名称: Serine/threonine-protein kinase PknB, ZINC ION
著者Prigozhin, D.M, TB Structural Genomics Consortium (TBSGC)
登録日2015-09-29
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
3OUV
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BU of 3ouv by Molmil
SeMet Derivative of L512M mutant of PASTA domain 3 of Mycobacterium tuberculosis PknB
分子名称: Serine/threonine protein kinase
著者Prigozhin, D.M, Chen, T.Y, Alber, T.
登録日2010-09-15
公開日2011-09-21
最終更新日2016-12-14
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
3ORP
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BU of 3orp by Molmil
Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 5)
分子名称: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine protein kinase
著者Good, M.C, Echols, N, Lombana, T.N, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB
Structure, 18, 2010
5U94
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BU of 5u94 by Molmil
Crystal structure of the Mycobacterium tuberculosis PASTA kinase PknB in complex with the potential theraputic kinase inhibitor GSK690693.
分子名称: 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3 -yn-2-ol, GLYCEROL, MAGNESIUM ION, ...
著者Wlodarchak, N, Satyshur, K, Striker, R.
登録日2016-12-15
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with beta-Lactams To Inhibit Mycobacterial Growth.
Mol. Pharm., 15, 2018
1O6Y
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BU of 1o6y by Molmil
Catalytic domain of PknB kinase from Mycobacterium tuberculosis
分子名称: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SERINE/THREONINE-PROTEIN KINASE PKNB
著者Ortiz-Lombardia, M, Pompeo, F, Boitel, B, Alzari, P.M, TB Structural Genomics Consortium (TBSGC)
登録日2002-10-21
公開日2003-01-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the Catalytic Domain of the Pknb Serine/Threonine Kinase from Mycobacterium Tuberculosis
J.Biol.Chem., 278, 2003
5E12
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BU of 5e12 by Molmil
Crystal Structure of PASTA Domains 2, 3 and 4 of Mycobacterium tuberculosis Protein Kinase B
分子名称: CITRATE ANION, Serine/threonine-protein kinase PknB
著者Prigozhin, D.M, TB Structural Genomics Consortium (TBSGC)
登録日2015-09-29
公開日2016-09-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.208 Å)
主引用文献Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
6I2P
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BU of 6i2p by Molmil
Crystal structure of the Mycobacterium tuberculosis PknB kinase domain (L33E mutant) in complex with its substrate GarA
分子名称: Glycogen accumulation regulator GarA, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Andre-Leroux, G, Hindie, V, Barilone, N, Bellinzoni, M, Alzari, P.M.
登録日2018-11-01
公開日2019-05-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
Sci.Signal., 12, 2019
3ORM
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BU of 3orm by Molmil
Mycobacterium tuberculosis PknB kinase domain D76A mutant
分子名称: MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine protein kinase
著者Echols, N, Lombana, T.N, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
Structure, 18, 2010
3F69
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BU of 3f69 by Molmil
Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720
分子名称: SULFATE ION, Serine/threonine-protein kinase pknB, hexyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8-tetrahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]c yclopenta[e]-as-indacene-6-carboxylate
著者Alber, T, Mieczkowski, C.A, TB Structural Genomics Consortium (TBSGC)
登録日2008-11-05
公開日2008-12-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.
Embo J., 27, 2008
2FUM
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BU of 2fum by Molmil
Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone
分子名称: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Probable serine/threonine-protein kinase pknB
著者Wehenkel, A, Alzari, P.M.
登録日2006-01-27
公開日2006-08-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria
Febs Lett., 580, 2006
3ORL
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BU of 3orl by Molmil
Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 3)
分子名称: MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine protein kinase
著者Echols, N, Lombana, T.N, Thomsen, N.D, Ng, H.-L, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2010-09-07
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB
Structure, 18, 2010
1MRU
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BU of 1mru by Molmil
Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Probable serine/threonine-protein kinase pknB
著者Young, T.A, Delagoutte, B, Endrizzi, J.A, Alber, T, TB Structural Genomics Consortium (TBSGC)
登録日2002-09-18
公開日2003-02-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases.
Nat.Struct.Biol., 10, 2003
6B2P
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BU of 6b2p by Molmil
Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis
分子名称: 5-{5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}thiophene-2-sulfonamide, Serine/threonine-protein kinase PknB
著者Zuccola, H.J.
登録日2017-09-20
公開日2018-02-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
ACS Med Chem Lett, 8, 2017
2KUI
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BU of 2kui by Molmil
NMR structure of the PASTA domain of Mycobacterium tuberculosis of PknB
分子名称: Serine/threonine-protein kinase pknB
著者Barthe, P, Mukamolova, G, Roumestand, C, Cohen-Gonsaud, M.
登録日2010-02-17
公開日2010-04-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2KUD
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BU of 2kud by Molmil
NMR structure of the PASTA domain 1 and 2 of Mycobacterium tuberculosis of PknB
分子名称: Serine/threonine-protein kinase pknB
著者Barthe, P, Mukamolova, G, Roumestand, C, Cohen-Gonsaud, M.
登録日2010-02-17
公開日2010-04-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2KUF
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BU of 2kuf by Molmil
NMR structure of the PASTA domain 3 and 4 of Mycobacterium tuberculosis of PknB
分子名称: Serine/threonine-protein kinase pknB
著者Barthe, P, Mukamolova, G, Roumestand, C, Cohen-Gonsaud, M.
登録日2010-02-17
公開日2010-04-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2KUE
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BU of 2kue by Molmil
NMR structure of the PASTA domain 2 and 3 of Mycobacterium tuberculosis of PknB
分子名称: Serine/threonine-protein kinase pknB
著者Barthe, P, Mukamolova, G, Roumestand, C, Cohen-Gonsaud, M.
登録日2010-02-17
公開日2010-04-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010

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